The long-term effect of coronavirus disease 2019 (COVID-19) has been rarely known. This study aimed to investigate healthy outcomes of COVID-19 survivors up to 2 years after the infection. A total of 155 COVID-19 patients, who were discharged from Shenzhen Third People's Hospital from February 2020 to April 2020, were enrolled and followed up until March 4, 2022. COVID-19 survivors received questionnaires of long COVID symptoms and psychological symptoms, pulmonary function tests, chest computed tomography...

Additional file 4: Fig. S1. Expressed lncRNAs in two crosses.

Additional file 5: Fig. S2. Expression levels of lncRNAs and PCgenes in sunflower endosperm.

Additional file 7: Fig. S4. DNA methylation profiles of protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Drug delivery and triggered release in tumor cells would realize the ultimate goal of precise cancer treatment. An APE1 triggered DNA nanoprism was designed, aiming at the applications of both drug delivery and precise triggered drug release in cancer cell. We demonstrate that the AP-Prism was successfully used as a vehicle based on the intracellular endogenous enzyme APE1 triggered for controlled drug delivery and triggered release. The box like DNA prism was self-assembled by annealing...

PD-1/PD-L1 inhibitors in combination with CTLA-4 inhibitors are being tested in a number of ongoing clinical trials. As a result, it is critical to fully comprehend the toxicity characteristics of adverse events in combination therapy. This study aims to extensively compare the incidences and ORs of treatment-related adverse events between two combination strategies. The eligible articles were searched from PubMed, EMBASE and Cochrane databases for studies published between 1 January 2010 and 1 May 2021,...

Additional file 4: Supplementary Table S4. Primer sequences utilized for real-time PCR in the present study.

Verify the applicability of three-level simulation to BDFA through experiments

Additional file 2:

Supporting information

To develop an easily applied predictive model to predict survival rate for infants with congenital diaphragmatic hernia (CDH) in the early postnatal period according to the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) guideline. The retrospective study was conducted including 225 neonates with prenatal or postnatal diagnosed CDH between 2001 and 2018. Patients did not receive the therapy of fetal endoscopic tracheal occlusion and extracorporeal membrane oxygenation. The study...

Additional file 1:

The experiment and results.

To investigate the molecular mechanism of the ADVENTITIOUS ROOTING RELATED OXYGENASE 1 (ARRO-1) gene in adventitious rooting of tree peony, the PsARRO-1 gene was isolated from Paeonia ostii. Subsequently, a yeast two-hybrid (Y2H) cDNA library using the split-ubiquitin yeast membrane system was constructed, the insert fragments lengths of pPR3-N membrane Y2H library were mainly concentrated between 500 and 3,000 bp, and the library capacity reached 1.3 × 107 CFUs, with an efficiency of recombinant of...

Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the accurate diagnosis of osteoporosis and better health care for prevention. This study aimed to investigate the efficacy of oxidative stress markers—8-oxo-7,8-dihydroguanine (8-oxoGsn) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) in the assessment of osteoporosis. We conducted a cross-sectional study among menopausal women with a mean...

The aim of this study was to develop a gambogic acid-loaded mixed micelles (GA-M) system, using Kolliphor HS15 and lecithin, for enhancement of oral bioavailability. GA-M was prepared using the thin film hydration method, and particle size and zeta potential indexes were used to determine the optimized formulation was optimized with taking particle size, zeta potential as indexes. The optimal GA-M system had a mean particle size in the nanometer range (87.22 ± 0.68 nm)...

Additional file 1: Fig. S1. Time series and predicting epidemic magnitude of CVA16 activity in Anhua county during 2013-2016 (A) and that in Hunan province during 2009-2018 (B). Fig. S2. Participants’ included time in baseline and follow-up times (A) and the epidemic seasons of CVA16 activity during 2009-2018 in Anhua, Hunan province (B). Fig. S3. Distribution of maternal antibody titre transfer ratio against CVA16 for all pairs of neonate-mother (A) and positive mothers with antibody...

Additional file 1: Fig. S1. Time series and predicting epidemic magnitude of CVA16 activity in Anhua county during 2013-2016 (A) and that in Hunan province during 2009-2018 (B). Fig. S2. Participants’ included time in baseline and follow-up times (A) and the epidemic seasons of CVA16 activity during 2009-2018 in Anhua, Hunan province (B). Fig. S3. Distribution of maternal antibody titre transfer ratio against CVA16 for all pairs of neonate-mother (A) and positive mothers with antibody...

Supplementary Material 1

Supplemental Document

Additional file 4: Table S1. Synthetic lethal interactive pairs and chemical inhibitors involving SWI/SNF members.

Additional file 5: Fig. S1. MβCD plus anti-GD2 treatment inhibits tumor growth in vivo. A, Schematic of MβCD and anti-GD2 treatments. B, Representative images of xenograft 9464D tumors with different treatments. C, The tumors were removed for weight analysis 21 days after the beginning of treatments. D, Tumor growth curves of subcutaneous 9464D cells with different treatments. Fig. S2. Monitoring of mouse weight during the experiment.

Verify the applicability of three-level simulation to BDFA through experiments

Supplemental material, sj-docx-1-sgo-10.1177_21582440221141299 for Correlation Monitoring Method and model of Science-Technology-Industry in the AI Field: A Case of the Neural Network by Xiaoli Wang, Yun Liu, Lingdi Chen and Yifan Zhang in SAGE Open

The new insecticide broflanilide, which possesses high insecticidal activity against agricultural pests, acts on the γ-aminobutyric acid receptor in the insect nervous system. At present, few studies assessed its effect on the nervous system of zebrafish, especially its sub-chronic toxicity on the zebrafish brain. In this study, the sub-chronic toxicity of broflanilide on the zebrafish brain was assessed. After 21 days of exposure at 36.3 μg/L, broflanilide caused oxidative damage to the zebrafish brain, increased...