Duloxetine is a commonly used antidepressant that is a serotonin and norepinephrine reuptake inhibitor. We aimed to investigate the frequency and severity of clinical effects following duloxetine overdose. We undertook a retrospective review of duloxetine overdoses (>120 mg) admitted to two tertiary toxicology units between March 2007 and May 2021. Demographic information, details of ingestion (dose, co-ingestants), clinical effects, investigations (ECG parameters including QT interval), complications (coma [GCS < 9], serotonin toxicity, seizures and cardiovascular...

A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 4: Supplemental Table S4. Primers used for qRT- PCR

Additional file 2. CRE-IQI network survey, 2019.

Additional file 2: Supplemental Table S2. ThesiRNA sequences of NC and siPCSK9

Additional file 4. Women's interview codebook.

Additional file 1. COREQ checklist.

Additional file 2. CHEERS checklist.

There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013–October 2014), reviewed after 4...

There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013–October 2014), reviewed after 4...

Additional file 1: Appendix 1.

Additional file 2. Online supplement 1.

Additional file 3. Characteristics of Included Studies.

Additional file 1. Supplementary Tables S1–S4 and Supplementary Figures S1–S2.

Additional file 1. Supplementary Tables S1–S4 and Supplementary Figures S1–S2.

Supplemental material, sj-docx-1-shr-10.1177_20542704221132139 for Open science and conflict of interest policies of medical and health sciences journals before and during the COVID-19 pandemic: A repeat cross-sectional study by Antoni D. Gardener, Ellen J. Hick, Chloe Jacklin, Gifford Tan, Aidan G. Cashin, Hopin Lee, David Nunan, Elaine C. Toomey and Georgia C. Richards in JRSM Open

Speech Pathology programs usually send students to workplaces to learn clinical skills necessary for practice. During COVID-19, programs needed to respond quickly to ensure that students continued to gain the necessary experiences and skills required to progress through their program and graduate as clinicians, while simultaneously complying with COVID-19 requirements. Case studies from seven different universities in Australia, Ghana and Hong Kong described the diverse ways in which placements were adapted to be COVID-safe, taking...

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Additional file 1. Interview guide for the evaluation planning consultations.

Additional file 4. Topic guide for the group discussions for the research impact assessment.

Additional file 1: Table S1. Summary of included studies classified as Theorizing. Table S2. Summary of included studies classified as Prediction. Table S3. Summary of included studies classified as Intervention development. Table S4. Summary of included studies classified as Process evaluation. Table S5. Summary of included studies classified as Impact evaluation. Table S6. Summary of included studied classified as Unclear systems approaches.

This study aimed to investigate rehabilitation staff perceptions of factors influencing stroke survivor activity outside of dedicated therapy time for the purpose of supporting successful translation of activity promoting interventions in a rehabilitation unit. Purposive sampling of multi-disciplinary teams from four rehabilitation units was performed, and semi-structured interviews were conducted by telephone, digitally audio-recorded and then transcribed verbatim. A stepped iterative process of thematic analysis was employed until data saturation was reached. All but one...

Additional file 5.

Additional file 5.

Additional file 6.