Supplementary Material 2

Additional file 5: Fig. S4. Heatmap of the ASVs that identified to be diarrheic status transition-associated in trial 2. The ASVs were identified based on fold change and analysis using LEfSe or DESeq2.

Additional file 11: Material and Methods.

Additional file 11: Material and Methods.

The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation of DNase I or the actin scavenger gelsolin. Splenocyte death and neutrophil extracellular trap (NET) clearance deficiencies were prevalent in individuals with severe COVID-19...

Additional file 1: Fig. S1. A) Schematic illustration of spatial offsets from implant planning. Analysis shows deviations in drilling depth, oro-vestibular as well as mesio-distal direction and angulation. B) Section of the Treatment Evaluation Tool in coDiagnostix®. Planning is shown in blue. Red shows the actual implant position. C) Mandible model used for the in vitro testing with pilot drilling guide in situ. D) DENACAM system used for the in vitro testing. E) Major findings...

Richmond agitation-sedation scale (RASS) is a simple and widely used tool for evaluating sedation and agitation in adult ICU patients. Early deep sedation has been shown to be an important independent predictor of death, however, studies on the role of RASS in the prognostic assessment of neurocritical patients are lacking. The purpose of this study was to investigate the relationship between RASS and in-hospital mortality in neurocritical patients, and to develop and validate an effective...

Additional file 1: Supplementary Figure S1. Genome coverage plot of B.intestinalis reported by Wochenende. Wochenende did not misclassify B. subtilis in the mock community by Sui et al (SRSRR11207337) [29], but rather detected B. intestinalis with a high and evenly distributed coverage. Indeed all the other tools also reported B. intestinalis instead of B. subtilis. Supplementary Figure S2. Wochenende analysis of an alternative long-read Zymo Even DNA mock community. The mock community was sequenced on...

Additional file 1: Table S1: Borrelia Antigens used in the Borrelia multiplex. Table S2: Assay precision and LOD of the Borrelia multiplex on different Luminex platforms. . Table S3: Cohen’s kappa coefficients for the comparison of the Borrelia multiplex with commercial Borrelia test. Table S4: Serostatus of 1,555 serum samples from a German serological survey (MuSPAD study). Figure S1: Dilution linearity of Borrelia multiplex on different Luminex platforms.. Figure S2: ROC analysis for Borrelia specific...

Additional file 1: Table S1: Borrelia Antigens used in the Borrelia multiplex. Table S2: Assay precision and LOD of the Borrelia multiplex on different Luminex platforms. . Table S3: Cohen’s kappa coefficients for the comparison of the Borrelia multiplex with commercial Borrelia test. Table S4: Serostatus of 1,555 serum samples from a German serological survey (MuSPAD study). Figure S1: Dilution linearity of Borrelia multiplex on different Luminex platforms.. Figure S2: ROC analysis for Borrelia specific...

Additional file 1: Fig. S1. Treatment scheme of inhaled and systemic administered mosliciguat and of vehicle treatment in the minipig model. Each animal underwent eight unilateral ventilation cycles and animals were divided into two groups.

Supplemental material, sj-docx-2-opp-10.1177_10781552221144303 for Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC by Clémence Delafoy, Hubert Benoist, Alex Patin, Michèle Vasseur, Sonia Guillouet, Clarisse Eveno, Jean-Marc Guilloit, Pascal Odou, Nicolas Simon and Guillaume Saint-Lorant in Journal of Oncology Pharmacy Practice

The organoid is a 3D cell architecture formed by self-organized tissues or cells in vitro with similar cell types, histological structures, and biological functions of the native organ. Depending on the unique organ structures and cell types, producing organoids requires individualized design and is still challenging. Organoids of some tissues, including adipose tissue, remain to generate to be more faithful to their original organ in structure and function. We previously established a new model of...

Additional file1: Figure S1. Representative immunohistochemical images of the expression of omentin1 in adipose tissues of mice injected with AAV-NC or AAV-omentin1, and the statistical results of staining intensity of omentin1 were presented, scale bar = 250 μm (n = 3). The experiments were performed in triplicate. Results were expressed as mean ± SD. ##P < 0.01, ####P < 0.0001 vs. the sham group; ****P < 0.0001 vs. the model group, one-way ANOVA. Figure S2....

Supplementary Material 3

Additional file 1: Fig. S1. A) Schematic illustration of spatial offsets from implant planning. Analysis shows deviations in drilling depth, oro-vestibular as well as mesio-distal direction and angulation. B) Section of the Treatment Evaluation Tool in coDiagnostix®. Planning is shown in blue. Red shows the actual implant position. C) Mandible model used for the in vitro testing with pilot drilling guide in situ. D) DENACAM system used for the in vitro testing. E) Major findings...

Additional file 1. Comparative subgroup analysis. Of 66 patients, we identified 28 children with crescentic glomeruli and/or nephrotic syndrome at onset of IgAVN. Referring to the German Society of Pediatric Nephology, a corticosteroid pulse therapy only would have been recommended. Of these 28 children, 17 received corticosteroid pulse therapy per protocol, 11 did not receive any immunosuppressive therapy. We therefore performed a comparative subgroup analysis which showed similar improvements of clinical symptoms and proteinuria.

Additional file 1: Fig. S1. A schematic showing the experimental design, milk feeding, and fecal sample collection of the two trials.

Additional file 2: Fig. S2. Heatmap of the ASVs associated with diarrheic status in stage 4 of trial 1. The ASVs were identified based on fold change and analysis using LEfSe or DESeq2.

Additional file 5: Fig. S4. Heatmap of the ASVs that identified to be diarrheic status transition-associated in trial 2. The ASVs were identified based on fold change and analysis using LEfSe or DESeq2.

Richmond agitation-sedation scale (RASS) is a simple and widely used tool for evaluating sedation and agitation in adult ICU patients. Early deep sedation has been shown to be an important independent predictor of death, however, studies on the role of RASS in the prognostic assessment of neurocritical patients are lacking. The purpose of this study was to investigate the relationship between RASS and in-hospital mortality in neurocritical patients, and to develop and validate an effective...

Supplementary Material 2

Supplementary Material 1

Supplementary Material 3

Additional file 1: Fig. S1. A schematic showing the experimental design, milk feeding, and fecal sample collection of the two trials.