Additional file 3: Fig. S3. Apoptosis or cycle changes in astrin-KO cells and identification of astrin-KO cell line. (A) Parental, astrin-KO and HCR-KO HeLa cells were analyzed with astrin, HCR, cyclin B1 and Cleaved PARP antibodies. HeLa cells treated with DMSO, Paclitaxel, Bafilomycin and MG132 were analyzed with Cleaved PARP and HCR antibodies. (B) Parental and astrin-KO HeLa cells were immunoblotted with an astrin antibody.

Additional file 13. Significantly Different Metabolites with increased N-formylmethionine at day 0 in both VITdAL-ICU and RoCI Cohorts.

Additional file 1. Supplemental Methods.

Supplementary Material 1

Supplemental material, sj-doc-2-mso-10.1177_20552173221132170 for Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis by Estelle Seyman, David Kim, Aditya Bharatha, Courtney Casserly, Kristen Krysko, Roy-Hewitson Chantal, Paula Alcaide-Leon, Suradech Suthiphosuwan and Jiwon Oh in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Supplemental material, sj-doc-2-mso-10.1177_20552173221132170 for Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis by Estelle Seyman, David Kim, Aditya Bharatha, Courtney Casserly, Kristen Krysko, Roy-Hewitson Chantal, Paula Alcaide-Leon, Suradech Suthiphosuwan and Jiwon Oh in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Additional file 3.

Additional file 12. Supplementary discussion.

Additional file 1.

Additional file 1.

Additional file 1. Figure S1: Study enrollment diagram. Legend: CONSORT diagram of participant enrollment for this Phase 1/2a clinical trial.

Additional file 4. Figure S1: Availability of plasma samples. The availability of plasma samples for analysis at each schedule collection time point. Blue and red blocks denote samples collected before and after disease recurrence, respectively. Abbreviations: LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma, RFS – recurrence-free survival, AT – adjuvant therapy, RT – radiotherapy, LNM – lymph node metastasis.

Additional file 1: Figure S1. Scatterplot of polymyxin B AUCss,24h versus dosage. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state. Figure S2. Scatterplot of polymyxin B AUCss,24h (a) and C0h (b) stratified for different stages of acute kidney injury. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state; C0h, trough concentration. Figure S3. Kaplan-Meier estimates of survival to 30 days after administration of polymyxin...

Additional file 11: TableS1.The comparison of clinical characteristics between CSF-ctDNA negative and positive subgroups at baseline (N = 92). Table S2. Univariate and multivariate Cox regression analyses of overall survival based on baseline variables (N = 92). Table S3. The comparison of clinical characteristics in patients with CSF ctDNA response and non-response after treatment (N = 25). Table S4. Univariate and multivariate Cox regression analyses of intracranial progression free survival based on baseline variables (N...

Additional file 2: Table S2: All gene targets of noncoding DNVs directly or indirectly associated with cardiomyopathy.

Additional file 1: Supplemental Table 1. Definitions of S-ACP in Electronic Health Records. Codes for structured advance care planning (S-ACP) documentation. Abbreviations: current procedural terminology (CPT), Physician Orders for Life-Sustaining Treatment (POLST). Supplemental Table 2. S-ACP Documentation Rate by Provider Type. Structured advance care planning (S-ACP) completion rates by provider type (includes providers that logged at least 450 patient encounters) based on encounters.

Additional file 1: Supplementary Figure S1. Evaluation of pathological changes in the cecum in mouse colitis models. Supplementary Figure S2. Effect of streptomycin and DSS treatment on intestinal inflammation and E. coli lactate utilization. Supplementary Figure S3. Contribution of Macrophage Infiltration to Host Production of Lactate During DSS Colitis.

Recent medical imaging studies have given rise to distinct but inter-related datasets corresponding to multiple experimental tasks or longitudinal visits. Standard scalar-on-image regression models that fit each dataset separately are not equipped to leverage information across inter-related images, and existing multi-task learning approaches are compromised by the inability to account for the noise that is often observed in images. We propose a novel joint scalar-on-image regression framework involving wavelet-based image representations with grouped penalties that...

Additional file 10: Table S5. Spearman correlations significance (P-value) between ASVs and testicular genes in the photoperiod experiment.

Additional file 3. Sepsis Knowledge Question Scoring Key

Additional file 6. Distribution of responses for items related to sepsis information access

Supplementary Material 7

Additional file 1: Figure S1. Increase in the optimized NPs uptake after aptamer functionalization in murine MSC (C3H10T1/2) and fibroblasts (BALB/3T3). (*) denotes statistical significance to non-functionalized NPs (LPNPs) p < 0.05 (n = 5).

Additional file 1: Figure S1. Increase in the optimized NPs uptake after aptamer functionalization in murine MSC (C3H10T1/2) and fibroblasts (BALB/3T3). (*) denotes statistical significance to non-functionalized NPs (LPNPs) p < 0.05 (n = 5).

Additional file 10. Post-course survey to assess the impact of the curriculum on the learners