Additional file 1.

Additional file 1. Detailed methods or results covered in this article.

The long-term effect of coronavirus disease 2019 (COVID-19) has been rarely known. This study aimed to investigate healthy outcomes of COVID-19 survivors up to 2 years after the infection. A total of 155 COVID-19 patients, who were discharged from Shenzhen Third People's Hospital from February 2020 to April 2020, were enrolled and followed up until March 4, 2022. COVID-19 survivors received questionnaires of long COVID symptoms and psychological symptoms, pulmonary function tests, chest computed tomography...

Additional file 1: Figure S1. Characterization of cDex and DETA-Dex. Figure S2. Kinetic analysis of the RNA droplets induced by the cationic polymers. Figure S3. Quantification of the transcription levels of common markers by RNA-seq. Figure S4. Gene Set Enrichment Analysis. Figure S5. Evaluation of antitumor activity of the cationic polymers in the BALB/c mouse model and BALB/c nude mouse model. Figure S6. Examples of the gating strategies for intracellular staining flow cytometry analysis. Figure...

Additional file 3: Fig. S3. Apoptosis or cycle changes in astrin-KO cells and identification of astrin-KO cell line. (A) Parental, astrin-KO and HCR-KO HeLa cells were analyzed with astrin, HCR, cyclin B1 and Cleaved PARP antibodies. HeLa cells treated with DMSO, Paclitaxel, Bafilomycin and MG132 were analyzed with Cleaved PARP and HCR antibodies. (B) Parental and astrin-KO HeLa cells were immunoblotted with an astrin antibody.

Additional file 2. SAP.

Additional file 3. Informed consent materials.

Additional file 4. Supplemental Method

Additional file 1: Supplementary Fig. 1. (A) RT-qPCR analyses of FOXD1 mRNA in the indicated breast tumor cell lines and MCF-10A. Error bars, SEM. n = 3. (B) Western blotting analyses of FOXD1 expression in the indicated breast tumor cell lines and MCF-10A. (C)RT-qPCR analysis of FOXD1 expression in control and sh-FOXD1 cells (MDA231 and MDA468), or control and FOXD1 overexpression cells (MCF-7). Error bars, SEM. n = 3. **p < 0.01, ***p<0.001 by Student’s...

Gustatory systems in phytophagous insects are used to perceive feeding stimulants and deterrents, and are involved in insect decisions to feed on particular plants. During the process, gustatory receptors (Grs) can recognize diverse phytochemicals and provide a molecular basis for taste perception. The silkworm, as a representative Lepidoptera species, has developed a strong feeding preference for mulberry leaves. The mulberry-derived flavonoid glycoside, isoquercetin, is required to induce feeding behaviours. However, the corresponding Grs for isoquercetin...

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

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Additional file 12. Volcano plots for the differential expression analysis. These plots depict the log2 fold-change (x-axis) against the -log10 of the uncorrected p-value (y-axis) for each gene in each pairwise comparison in the medial preoptic area (MPOA, A), nucleus accumbens (NAc, B), and lateral septum (LS, C). Differentially expressed genes are depicted in red.

Additional file 13. Functional enrichment of genes differentially expressed in the medial preoptic area (MPOA). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (A), cellular components (B), and molecular functions (C) categories were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively). The labels of pairwise comparisons were coded in two letters: the first one represents the phenotype (M: mothers, F: fathers, P: paternal males,...

Additional file 17. Functional enrichment of genes differentially expressed in the nucleus accumbens (NAc). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (A), cellular components (B), and molecular functions (C) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG, D) were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively). The labels of pairwise comparisons were coded in two...

Additional file 18. Functional enrichment of genes differentially expressed in the lateral septum (LS). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (A), cellular components (B), and molecular functions (C) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG, D) were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively). The labels of pairwise comparisons were coded in two...

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Additional file 1. Selection of clinical questions.

Additional file 1. Selection of clinical questions.

Additional file 3. Supplementary data for focused clinical questions.