101 Works

Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis

Ge Zhao, Jing Liu & Tao Meng
Previous studies have detected the association of polymorphisms in oxidative stress-related genes EPHX1 and MnSOD with pre-eclampsia (PE) risk, but the results are inconsistent among studies. Thus, a meta-analysis was performed to obtain more conclusive results. Eligible studies were retrieved in PubMed, Web of Science, EMBASE, Scopus, and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between EPHX1 rs1051740, EPHX1 rs2234922, MnSOD rs4880 polymorphisms, and PE susceptibility in...

Rumen bacteria and epithelial metabolism contribute to improving N utilization efficiency of calves

Ningning Zhang, Gaojie Hu, Kai Guo, Tong Fu, Hongxia Lian, Linfeng Wang & Tengyun Gao
The purpose of this study was to investigate the role of urea-N recycling, rumen bacterial community, and rumen epithelial gene expression in nitrogen utilization of calves. Here, 12 Holstein calves were divided into two dietary treatments: a high-protein diet (HP, 173 g/kg), and a low-protein diet (LP, 125 g/kg). Urea-N kinetics was evaluated using urea-15N15N isotope labeling method. Gene expression in rumen epithelium and liver, bacterial diversity, and metabolites in rumen were characterized using transcriptomic,...

Rumen bacteria and epithelial metabolism contribute to improving N utilization efficiency of calves

Ningning Zhang, Gaojie Hu, Kai Guo, Tong Fu, Hongxia Lian, Linfeng Wang & Tengyun Gao
The purpose of this study was to investigate the role of urea-N recycling, rumen bacterial community, and rumen epithelial gene expression in nitrogen utilization of calves. Here, 12 Holstein calves were divided into two dietary treatments: a high-protein diet (HP, 173 g/kg), and a low-protein diet (LP, 125 g/kg). Urea-N kinetics was evaluated using urea-15N15N isotope labeling method. Gene expression in rumen epithelium and liver, bacterial diversity, and metabolites in rumen were characterized using transcriptomic,...

The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies

Yu Li, Xiaoxuan Su, Qing Ye, Xiaodan Guo, Bo Xu, Tianjun Guan & Anqun Chen
This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) on further diabetic nephropathy (DN) risk in patients with type 2 diabetes (T2D) based on the prospective cohort studies. PubMed, Embase, and the Cochrane Library were systematically searched for eligible prospective cohort studies through March 2020. The predictive value of DR was assessed using sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and...

Improved kth power expectile regression with nonignorable dropouts

Dongyu Li & Lei Wang
The kth (1<k≤ 2) power expectile regression (ER) can balance robustness and effectiveness between the ordinary quantile regression and ER simultaneously. Motivated by a longitudinal ACTG 193A data with nonignorable dropouts, we propose a two-stage estimation procedure and statistical inference methods based on the kth power ER and empirical likelihood to accommodate both the within-subject correlations and nonignorable dropouts. Firstly, we construct the bias-corrected generalized estimating equations by combining the kth power ER and inverse...

Improved kth power expectile regression with nonignorable dropouts

Dongyu Li & Lei Wang
The kth (1<k≤ 2) power expectile regression (ER) can balance robustness and effectiveness between the ordinary quantile regression and ER simultaneously. Motivated by a longitudinal ACTG 193A data with nonignorable dropouts, we propose a two-stage estimation procedure and statistical inference methods based on the kth power ER and empirical likelihood to accommodate both the within-subject correlations and nonignorable dropouts. Firstly, we construct the bias-corrected generalized estimating equations by combining the kth power ER and inverse...

Additional file 1 of Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Fangyuan Li, Hua Lu, Xinxin Wang, Qi Zhang, Qianchen Liu & Tong Wang
Additional file 1.

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Yang Li, Zhouping Zou, Yunlu Zhang, Bowen Zhu, Yichun Ning, Bo Shen, Chunsheng Wang, Zhe Luo, Jiarui Xu & Xiaoqiang Ding
In this study, we applied a composite index of neutrophil-lymphocyte * platelet ratio (NLPR), and explore the significance of the dynamics of perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI). During July 1st and December 31th 2019, participants were prospectively derived from the ‘Zhongshan Cardiovascular Surgery Cohort’. NLPR was determined using neutrophil counts, lymphocyte and platelet count at the two-time points. Dose-response relationship analyses were applied to delineate the non-linear odds ratio (OR)...

Risk of Ophthalmic Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis

Yan-Li Hou, Di-Ya Wang, Jie-Xuan Hu, Ru-Yue Tian, Wei Wang, Qiang Su, Hongyang Li & Yan-Ling Wang
Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy. Methods: Eligible studies were selected from phase II/III randomized controlled trials investigating ICIs. The data were analyzed by R software and Stata. Odds ratio of treatment-related AE (trAEs) and nonspecific ophthalmic trAEs (NS-trAEs) were lower for PD-1/PD-L1...

Ensemble and calibration multiply robust estimation for quantile treatment effect

Xiaohong He & Lei Wang
Quantile treatment effects can be important causal estimands in the evaluation of biomedical treatments or interventions for health outcomes such as birthweight and medical cost. However, the existing estimators require either a propensity score model or a conditional density vector model is correctly specified, which is difficult to verify in practice. In this paper, we allow multiple models for propensity score and conditional density vector, then construct a class of calibration estimators based on multiple...

Systematic review and meta-analysis of the predictive power of MTHFR polymorphisms for pemetrexed drug efficacy and toxicity in non-small cell lung cancer patients

Yu Bai, Xu Ma & Yan-hua Zhang
We conducted a meta-analysis to determine if MTHFR polymorphisms are effective biomarkers for non-small cell lung cancer (NSCLC) patient survival and pemetrexed (PEM) treatment toxicity. Because of data heterogeneity, fixed or random effects models were chosen, and pooled HRs and 95% confidence intervals (CIs) were calculated. No correlation between MTHFR 677 C > T polymorphism and progression-free survival (PFS) or overall survival (OS) was detected in NSCLC patients; however, patients with the T allele benefited...

Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin

Changyong Luo, Yan Li, Xu Liang, Yifan Chen, Qiao Zou, Yurong Kong, Zhengguang Guo, Wei Sun & Xin Wang
Special electromagnetic field-treated water (SEW) and far-infrared radiation (FIR) can reduce acute respiratory distress syndrome (ARDS) in rats inflicted by lipopolysaccharides (LPSs). However, little is known about its underlying molecular mechanism. Differentially expressed proteins (DEPs) of SEW and FIR interventions were obtained from a proteomics database. A total of 89 DEPs were identified. Enrichment analysis of DEPs was performed using the Database for Annotation, Visualization, and Integrated Discovery. These DEPs were associated with the responses...

Comparison of EM-seq and PBAT methylome library methods for low-input DNA

Yanan Han, Galina Yurevna Zheleznyakova, Yanara Marincevic-Zuniga, Majid Pahlevan Kakhki, Amanda Raine, Maria Needhamsen & Maja Jagodic
DNA methylation is the most studied epigenetic mark involved in regulation of gene expression. For low input samples, a limited number of methods for quantifying DNA methylation genome-wide has been evaluated. Here, we compared a series of input DNA amounts (1–10ng) from two methylome library preparation protocols, enzymatic methyl-seq (EM-seq) and post-bisulfite adaptor tagging (PBAT) adapted from single-cell PBAT. EM-seq takes advantage of enzymatic activity while PBAT relies on conventional bisulfite conversion for detection of...

Alterations of oral microbiota in patients with panic disorder

Zunli Xie, Weiqing Jiang, Mingzhu Deng, Wei Wang, Xian Xie, Xia Feng, Yinping Shi, Xueyan Zhang, Dong Song, Ziyu Yuan & Yonggang Wang
The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship between oral microbiota and PD. Therefore, the objective of this study was to explore a possible correlation between oral microbiota and PD. We conducted 16S rRNA sequencing to compare differences in the...

POU class 2 homeobox associating factor 1 (POU2AF1) participates in abdominal aortic aneurysm enlargement based on integrated bioinformatics analysis

Jinze Meng, Hao Wen, Xintong Li, Boyang Luan, Shiqiang Gong, Jie Wen, Yifei Wang & Lei Wang
Abdominal aortic aneurysm (AAA) is life-threatening, its natural course is progressively sac expansion and rupture. Elegant studies have been conducted to investigate the molecular markers associated with AAA growth and expansion, this topic however, still needs to be further elucidated. This study aimed to identify potential genes for AAA growth and expansion based on comprehensive bioinformatics approaches. Firstly, 29 up-regulated genes were identified through DEGs analysis between large AAA and small AAA in GSE57691. Secondly,...

β-galactosidase GALA from Bacillus circulans with high transgalactosylation activity

Yaru Yan, Weishi Guan, Xiaoyi Li, Kaier Gao, Xinxin Xu, Bo Liu, Wei Zhang & Yuhong Zhang
β-galactosidase catalyzes lactose hydrolysis and transfers reactions to produce prebiotics such as galacto-oligosaccharides (GOS) with potential applications in the food industry and pharmaceuticals. However, there is still a need for improved transgalactosylation activity of β-galactosidases and reaction conditions of GOS production in order to maximize GOS output and reduce production costs. In this study, a β-galactosidase gene, galA, from Bacillus circulans was expressed in Pichia pastoris, which not only hydrolyzed lactose but also had strong...

sj-pdf-1-jfi-10.1177_0192513X211041992 – Supplemental Material for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender

Jing Zhang, Tineke Fokkema & Bruno Arpino
Supplemental Material, sj-pdf-1-jfi-10.1177_0192513X211041992 for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender by Jing Zhang, Tineke Fokkema and Bruno Arpino in Journal of Family Issues

Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infection

Yuchen Li, Jianda Li, Xiuyu Wang, Qingxin Wu & Qian Yang
Porcine epidemic diarrhea virus (PEDV) is emerging as a major threat to the global swine industry. Clinical PEDV infection is associated with severe intestinal lesions, resulting in absorptive dysfunction and high mortality rates in suckling piglets. The extracellular matrix (ECM) is an important component of intestinal tissue, providing a structural framework and conveying tissue-specific signals to nearby enterocytes. In this study, we investigated the extensive ECM remodeling observed in intestinal epithelial cells infected with PEDV...

Fetal cardiac geometry and function in pregnancies with well-controlled gestational diabetes mellitus using Fetal HQ

Yunyu Chen, Qin Chen, Yingheng Wu, Haiyu Wang, Qiyun Fan, Wenjia Lei, Rui Zhang, Yongen Liang & Hongying Wang
To determine whether abnormal cardiac shape and ventricular global, transverse, and longitudinal contractility are present in fetuses of women with well-controlled GDM. A prospective observational study was performed on 80 fetuses of women with well-controlled GDM and 90 control fetuses. Using Fetal HQ, a new speckle-tracking technique, cardiac shape, global contractility, transverse contractility, and longitudinal contractility were calculated. The number and percentage of fetuses with z score values below 5th or above 95th were computed....

sj-pdf-1-ajs-10.1177_03635465211030259 – Supplemental material for Quadriceps Tendon Autograft Versus Bone–Patellar Tendon–Bone and Hamstring Tendon Autografts for Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis

Wenli Dai, Xi Leng, Jian Wang, Jin Cheng, Xiaoqing Hu & Yingfang Ao
Supplemental material, sj-pdf-1-ajs-10.1177_03635465211030259 for Quadriceps Tendon Autograft Versus Bone–Patellar Tendon–Bone and Hamstring Tendon Autografts for Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis by Wenli Dai, Xi Leng, Jian Wang, Jin Cheng, Xiaoqing Hu and Yingfang Ao in The American Journal of Sports Medicine

Comparison of the accelerating effect of graphene oxide and graphene on anaerobic transformation of bisphenol F by Pseudomonas sp. LS

Hong Lu, Jingyi Li, Ze Fu, Xiaolei Wang, Jiti Zhou & Jing Wang
It was found that bisphenol F (BPF) could be anaerobically transformed to 4,4-dihydroxybenzophenone using nitrate as an electron acceptor by Pseudomonas sp. LS. However, BPF removal was a slow process under anaerobic conditions. In the present study, effects of graphene oxide (GO) and graphene on the anaerobic transformation of BPF were studied in detail. Results showed that GO (2–10 mg/L) and graphene (2–20 mg/L) could increase the anaerobic biotransformation rate of BPF. For GO-mediated system,...

Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives

Liang Su, Wei Li, Kexiong Liu & Qiuan Wang
A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2...

Comparison of EM-seq and PBAT methylome library methods for low-input DNA

Yanan Han, Galina Yurevna Zheleznyakova, Yanara Marincevic-Zuniga, Majid Pahlevan Kakhki, Amanda Raine, Maria Needhamsen & Maja Jagodic
DNA methylation is the most studied epigenetic mark involved in regulation of gene expression. For low input samples, a limited number of methods for quantifying DNA methylation genome-wide has been evaluated. Here, we compared a series of input DNA amounts (1–10ng) from two methylome library preparation protocols, enzymatic methyl-seq (EM-seq) and post-bisulfite adaptor tagging (PBAT) adapted from single-cell PBAT. EM-seq takes advantage of enzymatic activity while PBAT relies on conventional bisulfite conversion for detection of...

Single-machine scheduling with energy generation and storage systems

Hyun-Jung Kim, Eun-Seok Kim, Jun-Ho Lee, Lixin Tang & Yang Yang
This paper considers a single-machine scheduling problem with sequence-dependent setup times and energy-generation and storage systems. Each job requires a sequence-dependent setup to be processed on the machine, and both setup and processing of the job require job-dependent amounts of energy. The energy consumed by the machine can be bought from an Electric Power Company (EPC) or generated by own Distributed Energy Resource (DER), such as solar photovoltaic or wind, and the energy can be...

Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis

Ge Zhao, Jing Liu & Tao Meng
Previous studies have detected the association of polymorphisms in oxidative stress-related genes EPHX1 and MnSOD with pre-eclampsia (PE) risk, but the results are inconsistent among studies. Thus, a meta-analysis was performed to obtain more conclusive results. Eligible studies were retrieved in PubMed, Web of Science, EMBASE, Scopus, and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between EPHX1 rs1051740, EPHX1 rs2234922, MnSOD rs4880 polymorphisms, and PE susceptibility in...

Registration Year

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    101

Resource Types

  • Text
    101

Affiliations

  • Air Force Medical University
    101
  • Shanghai Jiao Tong University
    72
  • Sun Yat-sen University
    64
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    64
  • Sichuan University
    60
  • Fudan University
    60
  • Zhejiang University
    56
  • Shandong University
    56
  • Huazhong University of Science and Technology
    52
  • Chinese Academy of Sciences
    52