Additional file 1: Table S1. Frequency and percentage of missing variables. Table S2. Baseline characteristics of patients included and excluded due to missing data of TG, FBG and intracranial artery imaging. Table S3. Baseline characteristics of patients with or without sICAS. Table S4. Univariate logistic regression analysis of risk factors associated with sICAS. Table S5. Univariate linear regression analysis of risk factors associated with ICASB. Table S6. Subgroup analysis between TyG index and the degree...

Additional file 1: Table S1. Plasmids used in this study. Table S2. S.cerevisiae strains used in this study. Table S3. Codon optimized genes used in this study. Table S4. Oligonucleotides used in this study. Table S5. Constructed DNA modules in this study. Table S6. Homology sequences for integration sites at S. cerevisiae chromosome.

Additional file 2: Table S1. Independent genome-wide significant lead SNPs associated with pulmonary embolism (PE) in the discovery stage and replication stage. Table S2. The allele frequency of identified loci in 1000Genomes. Table S3. Replication of associations for the known loci in our cohort. Table S4. Association results for genes that were significant in FUMA gene-based analysis. Table S5. Polygenic risk score variants. Table S6. Polygenic risk score (PRS) quantile and odds ratio (OR).

Supplemental Material for Chinese diaspora caregivers’ experiences in dementia care in high-income countries: A systematic review by Yujing Zhang, Lily Xiao, and Jing Wang in Dementia

The score and prognostic value of necroptosis were analyzed in the TCGA and GSE120622 datasets. Necroptosis has the highest correlation with the immune microenvironment, and the high score in NSCLC correlates with poor prognosis. Differentially expressed genes between non-small cell lung cancer (NSCLC) and controls in both datasets were identified and subjected to construct co-expression networks, respectively. Black and blue modules were selected because of high correction with necroptosis. The intersected two module genes were...

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231170037 for Potential role of plasma branched-chain amino acids in the differential diagnosis of acute cerebral venous thrombosis by Huimin Jiang, Chen Zhou, Huimin Wei, Yan Wu, Yifan Zhou, Xuechun Xiao, Lu Liu, Ming Li, Jiangang Duan, Ran Meng and Xunming Ji in Journal of Cerebral Blood Flow & Metabolism

Four new polyhydroxylated steroidal saponins, parisverticillatosides A-D (1–4), together with four known spirostanol saponins (5–8) were isolated from the roots of Paris verticillata. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1–4 extended the diversity and complexity of this spirostanol saponin family. The saponins 5 and 6 exhibited cytotoxicities against two human glioma cell lines.

Additional file 1: Figure S1. Expression pattern of ASAP2 across different types of normal tissues and cancers. (A) ASAP2 expression across different types of normal tissues according to GTEx dataset. (B) ASAP2 expression across different types of normal tissues according to HPA dataset. (C) ASAP2 expression across different types of normal tissues according to FANTOM5 dataset. (D) ASAP2 expression across different types of cancer according to TCGA dataset. Figure S2. Correlation between ASAP2 and prognosis...

Supplemental Material for Childhood Sexual Abuse: A Longitudinal Study of Disclosures and Denials by Dana T. Hartman, Yan Wang, Daisy Vidales, Gail S. Goodman, Yuerui Wu, Deborah Goldfarb, Jianjian Qin, and Michell L. Eisen in Child Maltreatment

Additional file 1: Fig. S1. Differential transcriptomic and mutational profiles in PM gliomas with or without 1p19q co-deletion. Fig. S2. Declining expression of NFOL and MFOL signatures in PM gliomas from GSE4290. Fig. S3. Declining expression of NFOL and MFOL signatures in PM gliomas from the REMBRANDT dataset. Fig. S4. Genes upregulated in the PM gliomas were enriched in murine OPCs. Fig. S5. Genes concordantly enriched in both PM subtypes were differentially expressed between OPC...

TEM images, XRD patterns, Emission spectra, lifetimes, etc.

Additional file 1: Figure S1. Gene ontology enrichment analysis of 36 genes. a Mitotic nuclear division was main annotation in the biological process category. b Chromosomal region was main annotation in the cellular component category. c Histone kinase activity was main annotation in the molecular function category.

Additional file 1: Figure S1. Gene ontology enrichment analysis of 36 genes. a Mitotic nuclear division was main annotation in the biological process category. b Chromosomal region was main annotation in the cellular component category. c Histone kinase activity was main annotation in the molecular function category.

Additional file 2. Model consent form (Chinese).

Additional file 3. SPIRIT checklist.

Additional file 1: Fig. S1. Scatter plot of relationship between TV in 2010–14 and prevalence of diseases and conditions in China. TV, temperature variability. Fig. S2. Scatter plot of relationship between TV in 2011–14 and prevalence of diseases and conditions in China. TV, temperature variability. 4. Fig. S3. Scatter plot of relationship between TV in 2012–14 and prevalence of diseases and conditions in China. TV, temperature variability. Fig. S4. Scatter plot of relationship between TV...

Additional file 1. Supplementary tables and figures.

We extend three robust tests – Wald-type, the likelihood ratio-type and F-type in functional linear models with the scalar dependent variable and the functional covariate. Based on the percentage of variance explained criterion, we use the functional principal components analysis and re-express a functional linear model to a finite regression. We investigate the theoretical properties of these robust testing procedures and assess the finite sample properties through the numerical simulation. In our experiments, the power...

Additional file 1: Fig S1. Representative flow cytometry gating strategy for early-exhausted (PD-1int) and terminally-exhausted (PD-1hi) CD8+ T cells isolated from the tumor of a LLC mouse.

Additional file 1: Table S1. General features of the explosive eye injuries (total of 1115 patients). Fig. S1. Distribution of the number of patients and the proportions of male patients and bilateral eye injuries in different age groups.

Additional file 1: Supplementary Table 1. The datasets used for analysis. Supplementary Table 2. The top 10 hub genes rank in Cytohubba. Supplementary Table 3. The details of the hub genes. Supplementary Table 4. The key transcriptional factors (TFs) of hub genes.

Additional file 2: Supplementary Table 2. Genetic Correlation Estimates for Gut microbiota and Longevity by LDSC regression analysis.

Prodigiosin (2-methyl-3-pentyl-6-methoxyprodiginine) is a valuable medicinal and edible natural pigment derived from Serratia marcescens. How prodigiosin synthesis is suppressed by environmental factors has not been investigated. Previous studies described a low level of prodigiosin production in the presence of yeast extracts. However, we have observed that S. marcescens SDSPY-136 did not synthesize prodigiosin in yeast extract culture. In this study, transcriptome sequencing of yeast extract cultures was used to estimate the metabolic control of the...

The envelope model is a recently developed methodology for multivariate analysis that enhances estimation accuracy by exploiting the relation between the mean and eigenstructure of the covariance matrix. We extend the envelope model to function-on-function linear regression, where the response and the predictor are assumed to be random functions in Hilbert spaces. We use a double envelope structure to accommodate the eigenstructures of the covariance operators for both the predictor and the response. The central...

Supplemental material, sj-docx-1-tan-10.1177_17562864221147743 for Early neurological deterioration in patients with acute ischemic stroke: a prospective multicenter cohort study by Hongbing Liu, Kai Liu, Ke Zhang, Ce Zong, Hongxun Yang, Yapeng Li, Shen Li, Xin Wang, Jiawei Zhao, Zongping Xia, Bo Song, Xuming Xu and Yuan Gao in Therapeutic Advances in Neurological Disorders