Additional file 1: Suppl. Fig. 1. RET fusions were identified in 3 patients. A. H&E and α-thyroglobulin staining of indicated patients’ tumor tissues. B. Summary of patients’ features. C. Circos plots showing RET fusions detected in patients 14, 15 and 21. D./E. RET fusions detection by qPCR (E) and RT-PCR (F) in indicated samples. F. BAIAP2L1-BRAF detection by qPCR (upper panel) and RT-PCR (lower two panels) in the indicated patients’ samples. The upper graph shows...

Supplemental Material, sj-pdf-1-hfs-10.1177_00187208211060586 for Guiding Attention via a Cognitive Aid During a Simulated In-Hospital Cardiac Arrest Scenario: A Salience Effort Expectancy Value Model Analysis by Tobias Grundgeiger, Annabell Michalek, Felix Hahn, Thomas Wurmb, Patrick Meybohm and Oliver Happel in Human Factors: The Journal of Human Factors and Ergonomics Society

Supplementary Material 1

Supplementary Material 1

Supplement Document

Supplementary document

There is currently no cure for dementia but general practitioners (GPs) have therapeutic options available to counteract the progression of mild cognitive impairment, including drug and non-drug treatment. So far, few studies have investigated treatment strategies preferred by GPs. This study aimed to gain an overview of GPs’ attitudes towards influencing the progression of dementia, their involvement regarding dementia prevention and perceived effective approaches. It also elucidated the challenges experienced by GPs and desired optimisation...

There is currently no cure for dementia but general practitioners (GPs) have therapeutic options available to counteract the progression of mild cognitive impairment, including drug and non-drug treatment. So far, few studies have investigated treatment strategies preferred by GPs. This study aimed to gain an overview of GPs’ attitudes towards influencing the progression of dementia, their involvement regarding dementia prevention and perceived effective approaches. It also elucidated the challenges experienced by GPs and desired optimisation...

Supplemental material, sj-docx-1-tan-10.1177_17562864221142924 for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study by Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp and Stefan Bittner in Therapeutic Advances in Neurological Disorders

Additional file 1 Supplementary material, supporting figures and tables.

Additional file 1 Supplementary material, supporting figures and tables.

Supplementary document

DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA population study and replication in a multi-ethnic cohort of 344 individuals. We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to...

Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here, we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titres (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5...

Supplement Document

Supplement Document

Since 2020, physicians in Germany can prescribe approved digital health applications (DHAs) with the costs covered by the health system. There has so far been a lack of studies on attitudes and experiences amongst GPs in using DHAs. The aim was to elucidate the experiences and observations of GPs that have used DHAs in health care and to examine the conditions necessary for DHAs to gain a foothold in primary care according to the GPs....

Since 2020, physicians in Germany can prescribe approved digital health applications (DHAs) with the costs covered by the health system. There has so far been a lack of studies on attitudes and experiences amongst GPs in using DHAs. The aim was to elucidate the experiences and observations of GPs that have used DHAs in health care and to examine the conditions necessary for DHAs to gain a foothold in primary care according to the GPs....

Supplemental material, sj-docx-1-tan-10.1177_17562864221142924 for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study by Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp and Stefan Bittner in Therapeutic Advances in Neurological Disorders

Additional file 1: Supplementary Note S1. Assembly of Neoechinorhynchus buttnerae draft genome. Supplementary Note S2. Assembly of Neoechinorhynchus agilis draft genome. Supplementary Table S1. Transcript abundance differences of candidates. Supplementary Table S2. Amino acid composition of candidate target proteins. Supplementary Table S3. Properties of target proteins. Supplementary Table S4. PFAM motifs of target proteins. Supplementary Table S5. 3D structure prediction of target proteins. Supplementary Table S6. Virtual ligand screening results. Supplementary Table S7. Bacterial genome...

Supplementary document

Supplementary document

Supplementary Material 1

Additional file 1: Suppl. Fig. 1. RET fusions were identified in 3 patients. A. H&E and α-thyroglobulin staining of indicated patients’ tumor tissues. B. Summary of patients’ features. C. Circos plots showing RET fusions detected in patients 14, 15 and 21. D./E. RET fusions detection by qPCR (E) and RT-PCR (F) in indicated samples. F. BAIAP2L1-BRAF detection by qPCR (upper panel) and RT-PCR (lower two panels) in the indicated patients’ samples. The upper graph shows...

Supplemental Material, sj-pdf-1-hfs-10.1177_00187208211060586 for Guiding Attention via a Cognitive Aid During a Simulated In-Hospital Cardiac Arrest Scenario: A Salience Effort Expectancy Value Model Analysis by Tobias Grundgeiger, Annabell Michalek, Felix Hahn, Thomas Wurmb, Patrick Meybohm and Oliver Happel in Human Factors: The Journal of Human Factors and Ergonomics Society