4 Works

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Fengyi Zhao, Xu Sun, Wen Lu, Li Xu, Jiuzhou Shi, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin & Fuliang Cao
Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of L1−L10 (IC50 = 5.92− >100 μM) was lower than L0 (1.27 μM) and DOX (4.40 μM) in every case. Compound L1 had higher anti-HepG2...

Atanasije Stojković’s innovative Observation of the Sky

Dragana Grbić
This paper analyses a chapter from the second volume of Fisika [Physics] (Buda, 1802) by Atanasije Stojković, entitled “Šari aerostatičeski” [Aerostatic Balloons], in which the author provided an account of the cutting edge of contemporaneous technology—the hot-air balloon. The description of the construction and use of the hot-air balloon also reveals a line of transition from theodicy to technodicy. Finally, by considering this chapter within the entire context of Stojković’s three-volume scholarly work, the hot-air...

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Fengyi Zhao, Xu Sun, Wen Lu, Li Xu, Jiuzhou Shi, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin & Fuliang Cao
Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of L1−L10 (IC50 = 5.92− >100 μM) was lower than L0 (1.27 μM) and DOX (4.40 μM) in every case. Compound L1 had higher anti-HepG2...

Geophysical Survey at Morgantina

Stephen Kay, Monika Trümper , Michael Heinzelmann & Elena Pomar
Geophysical surveys were conducted at Morgantina in 1970, 2012 and 2018, with the objective of better understanding the city plan of the Archaic city on the Cittadella Hill and the Classical and Hellenistic city on the Serra Orlando Ridge. This paper focuses on the results of the 2018 survey conducted over three sectors on the Serra Orlando Ridge. It demonstrates that magnetometry was successful in rapidly recording subsurface archaeological features across the site, including the...

Registration Year

  • 2020
    4

Resource Types

  • Text
    4

Affiliations

  • University of Cologne
    4
  • Jiangsu Academy of Agricultural Sciences
    2
  • Sun Yat-sen University
    2
  • The Ohio State University Wexner Medical Center
    2
  • Jiaxing University
    2
  • The Ohio State University
    2
  • Peking University Stomatological Hospital
    2
  • Fudan University
    2
  • Second Affiliated Hospital of Kunming Medical College
    2
  • Nanjing University
    2