36 Works

Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population

Qian Xin, Gang Xin, Li Li, Wenjuan Sun, Wen Jiang, Jue Wang, Yun Luan, Ying Zhang, Ling Cheng, Shuhong Duan, Fanzhen Hong, Qinghong Ji & Weihong Ma
Preeclampsia (PE) is a disorder that occurs during the pregnancy and could affect the maternal and perinatal mortality as well as morbidity. The aim of our study is to investigate the associations between the hypertension susceptibility genes ITGA9, MOV10 and CACNB2 with PE in Chinese Han population. A case–control study including 178 PE patients and 202 healthy controls was conducted to assess the associations between three loci (ITGA9 rs155524, MOV10 rs2932538 and CACNB2 rs4373814) and...

Air-assisted liquid-liquid micro-extraction based on the solidification of a floating organic droplet for the determination of three strobilurin fungicides in water samples

Huihui Wang, Yue Wang, Xu Jing, Zhenjia Chen & Xiaowen Wang
A simple, fast, air-assisted liquid-liquid micro-extraction technique using the solidification of a floating organic droplet method was developed for the extraction of three strobilurin fungicides in water samples before analysis by high-performance liquid chromatography equipped with a diode array detector (HPLC-DAD). In this method, a low-density solvent (1-dodecanol) was used as the extraction solvent. Fine extraction solvent droplets were rapidly formed and dispersed into the water samples through air-pumping by syringe rather than an organic...

Air-assisted liquid-liquid micro-extraction based on the solidification of a floating organic droplet for the determination of three strobilurin fungicides in water samples

Huihui Wang, Yue Wang, Xu Jing, Zhenjia Chen & Xiaowen Wang
A simple, fast, air-assisted liquid-liquid micro-extraction technique using the solidification of a floating organic droplet method was developed for the extraction of three strobilurin fungicides in water samples before analysis by high-performance liquid chromatography equipped with a diode array detector (HPLC-DAD). In this method, a low-density solvent (1-dodecanol) was used as the extraction solvent. Fine extraction solvent droplets were rapidly formed and dispersed into the water samples through air-pumping by syringe rather than an organic...

Maternal asthma during pregnancy and extremes of body mass index increase the risk of perinatal mortality: a retrospective cohort study

Jui Das, Christine Andrews, Vicki Flenady & Vicki L. Clifton
Asthma during pregnancy and extremes of body mass index (BMI) are independently associated with adverse pregnancy outcomes but the impact of the two conditions combined are currently unknown. The aim of this study was to determine the contribution of maternal BMI to adverse birth outcomes in pregnancies complicated by asthma. The study utilized the routinely collected perinatal data on births at the Mater Mother’s Hospital Brisbane, Australia, from January 2008 to December 2019. BMI was...

Injury perceptions and their association with recovery outcomes in adults with traumatic orthopaedic injuries: a scoping review

Prudence Butler, Thi Nguyen, Melita J. Giummarra, Shaun O’Leary & Michele Sterling
How people perceive their injury may be associated with recovery. This scoping review used the Common Sense Model of Illness Perceptions (CSM) as a framework to: (1) characterise injury perceptions; (2) describe biopsychosocial factors related to injury perceptions, and (3) determine how injury perceptions are associated with recovery outcomes. A broad search strategy was used across eight databases to identify studies exploring injury perceptions and related concepts in adults with traumatic orthopaedic injuries. Two reviewers...

Additional file 2 of Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study

Yingjie Ma, Xianling Cao, Jingyan Song, Dandan Gao, Xinlei Wang, Li Li & Zhengao Sun
Additional file 2. Schedule of the study process

Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract

Matthew J. Sullivan, Kelvin G. K. Goh, Ruby Thapa, Debasish Chattopadhyay, Deepak S. Ipe, Benjamin L. Duell, Lahiru Katupitiya, Dean Gosling, Dhruba Acharya & Glen C. Ulett
Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH), encoded by gapC, is a glycolytic enzyme that is associated with virulence and immune-mediated protection. However, the role of GAPDH in cellular cytokine responses to S. agalactiae, bacterial phagocytosis and colonization of the female reproductive tract, a central host niche, is unknown. We expressed and studied purified recombinant GAPDH (rGAPDH) of S. agalactiae in cytokine elicitation assays with human monocyte-derived macrophage, epithelial cell, and polymorphonuclear leukocyte (PMN) co-culture infection...

Women’s and clinician’s acceptability of participation in a hypothetical obstetric randomized controlled trial: a qualitative survey

Helen C. Sherrell, Liam T. B. Dunn, Dell Horey, Vicki Flenady & Sailesh Kumar
Involving patients and consumers in research design helps ensure relevance for those affected by the problem being investigated and can optimize recruitment to clinical trials. This is particularly important when conducting research involving pregnant women. We investigated women’s motivations to participate in a hypothetical randomized control trial (RCT) of a third-trimester screening test for intrapartum fetal compromise (IFC) and adverse perinatal outcomes. Women attending for routine antenatal care at a tertiary center were invited to...

Association of soft drink and 100% fruit juice consumption with all-cause mortality, cardiovascular diseases mortality, and cancer mortality: A systematic review and dose-response meta-analysis of prospective cohort studies

Bei Pan, Long Ge, Honghao Lai, Qi Wang, Qian Zhang, Min Yin, Sheng Li, Jinhui Tian, Kehu Yang & Jiancheng Wang
Sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and 100% fruit juices are frequently consumed and have been documented that they could lead to serious disease burden. However, inconsistent evidence on the association between SSBs, ASBs, and 100% fruit juices consumption and mortality have been presented. PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and PsycINFO were systematically searched. We conducted a random-effects meta-analysis and dose-response meta-analysis to assess the association and calculated...

Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract

Matthew J. Sullivan, Kelvin G. K. Goh, Ruby Thapa, Debasish Chattopadhyay, Deepak S. Ipe, Benjamin L. Duell, Lahiru Katupitiya, Dean Gosling, Dhruba Acharya & Glen C. Ulett
Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH), encoded by gapC, is a glycolytic enzyme that is associated with virulence and immune-mediated protection. However, the role of GAPDH in cellular cytokine responses to S. agalactiae, bacterial phagocytosis and colonization of the female reproductive tract, a central host niche, is unknown. We expressed and studied purified recombinant GAPDH (rGAPDH) of S. agalactiae in cytokine elicitation assays with human monocyte-derived macrophage, epithelial cell, and polymorphonuclear leukocyte (PMN) co-culture infection...

Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death

Feng Shi, Luquan Zhang, Xing Liu & Yue Wang
MicroRNAs (miRNAs) are small non-coding RNAs that are closely associated with cancer progression and drug resistance, however, up until now, the involvement of miR-556-5p in regulating cisplatin-sensitivity in non-small cell lung cancer (NSCLC) has not been studied. In the present study, we found that miR-556-5p was significantly upregulated in the cisplatin-resistant NSCLC (CR-NSCLC) patients’ tissues and cells, instead of the corresponding cisplatin-sensitive NSCLC (CS-NSCLC) tissues and cells. Further experiments validated that knock-down of miR-556-5p suppressed...

Women’s and clinician’s acceptability of participation in a hypothetical obstetric randomized controlled trial: a qualitative survey

Helen C. Sherrell, Liam T. B. Dunn, Dell Horey, Vicki Flenady & Sailesh Kumar
Involving patients and consumers in research design helps ensure relevance for those affected by the problem being investigated and can optimize recruitment to clinical trials. This is particularly important when conducting research involving pregnant women. We investigated women’s motivations to participate in a hypothetical randomized control trial (RCT) of a third-trimester screening test for intrapartum fetal compromise (IFC) and adverse perinatal outcomes. Women attending for routine antenatal care at a tertiary center were invited to...

Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities

Ying Chen, Li Li, Li-Rui Jiang, Jia-Yin Tan, Li-Na Guo, Xiao-Li Wang, Wei Dong, Wen-Bao Wang, Ji-Kai Sun & Bo Song
Two new alkaloids, phranisines A–B (1–2), along with two known compounds, N-p-Coumaroyl serotonin (3) and N-p-coumaroyl-tryptamine (4), were isolated from the roots of Phragmites australis. The structures of 1–4 were established on the basis of extensive spectroscopic. The absolute configuration of compounds 1–2 were identified through quantum-chemical electronic circular dichroism (ECD) calculation compared with their experimental CD. All the isolated compounds were tested for their cytotoxic activities against HeLa and MCF-7 human cancer cell lines,...

Additional file 4 of Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders

Weichen Song, Wei Qian, Weidi Wang, Shunying Yu & Guan Ning Lin
Additional file 4. Funnel plots for top MR findings, leave-one-out results for top DTI-Disorder pairs, general contribution of DTI to neuropsychiatric disease after sensitivity test adjustment, Rank-Rank overlaps between MR effect and heterogeneity for ROI-Disease analysis.

Grape seed proanthocyanidin extract regulates lipid metabolism of the American eel (Anguilla rostrata)

Yue Wang, Xue-hao Chen, Guo-he Cai & Shao-wei Zhai
The current study was aimed to examine the effect of grape seed proanthocyanidin extract (GSPE) on regulating lipid metabolism of American eels. A total of six cement tanks of fish were randomly divided into a control group fed with a commercial diet and a GSPE group fed with a commercial diet supplemented 400 mg/kg GSPE. There were three replicates in each group. Results suggested that GSPE could decrease the levels of total cholesterol, triglycerides, and...

Valuing Cooperation and Constructive Controversy: A Tribute to David W. Johnson

Dean Tjosvold, Daniel Druckman, Roger Johnson, Karl Smith & Cary Roseth

Genetic analysis of Vietnamese patients with early-onset Alzheimer's disease

Trang Mai Tong, Thuy Thi Hong Dao, Loc Phuoc Doan, Dat Thanh Nguyen, Quynh-Tho Thi Nguyen, Thanh-Thuy Thi, Kiet Dinh Truong, Minh-Duy Phan, Hoai-Nghia Nguyen, Thang Cong Tran & Hoa Giang
Purpose of the study: Alzheimer's disease (AD) is the most common type of dementia and its prevalence is rapidly increasing worldwide. Early-onset Alzheimer's disease (EOAD) constitutes of patients with age of onset earlier than 65 year-old and is known to be associated with genetic mutations. In this study, we reported the first genetic analysis of Vietnamese patients with EOAD. Materials and methods: We analyzed targeted sequencing data obtained from a cohort of 51 Vietnamese EOAD...

Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population

Qian Xin, Gang Xin, Li Li, Wenjuan Sun, Wen Jiang, Jue Wang, Yun Luan, Ying Zhang, Ling Cheng, Shuhong Duan, Fanzhen Hong, Qinghong Ji & Weihong Ma
Preeclampsia (PE) is a disorder that occurs during the pregnancy and could affect the maternal and perinatal mortality as well as morbidity. The aim of our study is to investigate the associations between the hypertension susceptibility genes ITGA9, MOV10 and CACNB2 with PE in Chinese Han population. A case–control study including 178 PE patients and 202 healthy controls was conducted to assess the associations between three loci (ITGA9 rs155524, MOV10 rs2932538 and CACNB2 rs4373814) and...

Additional file 4 of Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders

Weichen Song, Wei Qian, Weidi Wang, Shunying Yu & Guan Ning Lin
Additional file 4. Funnel plots for top MR findings, leave-one-out results for top DTI-Disorder pairs, general contribution of DTI to neuropsychiatric disease after sensitivity test adjustment, Rank-Rank overlaps between MR effect and heterogeneity for ROI-Disease analysis.

Association of soft drink and 100% fruit juice consumption with all-cause mortality, cardiovascular diseases mortality, and cancer mortality: A systematic review and dose-response meta-analysis of prospective cohort studies

Bei Pan, Long Ge, Honghao Lai, Qi Wang, Qian Zhang, Min Yin, Sheng Li, Jinhui Tian, Kehu Yang & Jiancheng Wang
Sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and 100% fruit juices are frequently consumed and have been documented that they could lead to serious disease burden. However, inconsistent evidence on the association between SSBs, ASBs, and 100% fruit juices consumption and mortality have been presented. PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and PsycINFO were systematically searched. We conducted a random-effects meta-analysis and dose-response meta-analysis to assess the association and calculated...

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness

Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia & Hongbin Xiao
Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. The viability and Hif-1α levels of microglia and neurons at 5% O2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin,...

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness

Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia & Hongbin Xiao
Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. The viability and Hif-1α levels of microglia and neurons at 5% O2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin,...

The impact of obstacles to health and rehabilitation services on functioning and disability: a prospective survey on the 12-months after discharge from specialist rehabilitation for acquired brain injury

Melissa Legg, Michele Foster, Rachel Jones, Melissa Kendall, Jennifer Fleming, Mandy Nielsen, Elizabeth Kendall, David Borg & Timothy Geraghty
Little is known about obstacles to health and rehabilitation services experienced by people with acquired brain injury (ABI) over time and what impact these have on recovery. This study utilised the International Classification of Functioning, Disability, and Health model to better understand the impact of service obstacles. The aims were: (1) describe and compare service obstacles reported in the 12-months post-discharge from inpatient rehabilitation; (2) examine service obstacles as a moderator of the relationship between...

Family, neighborhood and psychosocial environmental factors and their associations with asthma in Australia: a systematic review and Meta-analysis

K. M. Shahunja, Peter D. Sly, Tahmina Begum, Tuhin Biswas & Abdullah Mamun
Various associations between different environmental exposures and asthma have been reported in different countries and populations. We aimed to investigate the associations between family, neighborhood and psychosocial environmental factors and asthma-symptoms in Australia by conducting a systematic review and meta-analysis. We analyzed the primary research studies conducted in Australia across multiple databases, including PubMed, EMBASE and Scopus, published between 2000 and 2020. The reviews and analyses focused on the overall association of different environmental exposures...

Additional file 1 of Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study

Yingjie Ma, Xianling Cao, Jingyan Song, Dandan Gao, Xinlei Wang, Li Li & Zhengao Sun
Additional file 1. Technical route.

Registration Year

  • 2021
    36

Resource Types

  • Text
    36

Affiliations

  • University of Queensland
    36
  • Capital Medical University
    16
  • Peking University
    16
  • Fudan University
    13
  • Central South University
    12
  • Tongji University
    12
  • Third Affiliated Hospital of Southern Medical University
    10
  • Huazhong Agricultural University
    10
  • University of Science and Technology of China
    10
  • Jiangsu Province Hospital
    10