Helicobacter pylori (H. pylori) recurrence remains a significant public health concern. The study aimed to assess H. pylori reinfection rate and identify its risk factors in China. This prospective open cohort, observational study was performed at 18 hospitals across 15 provinces in China. Consecutive patients who received the successful initial eradication during 1 January 2012 and 31 December 2018 were eligible for enrolment. H. pylori recurrence was defined as reinfection that occurred at more than...

The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a...

It is a common approach to dichotomize a continuous biomarker in clinical setting for the convenience of application. Analytically, results from using a dichotomized biomarker are often more reliable and resistant to outliers, bi-modal and other unknown distributions. There are two commonly used methods for selecting the best cutoff value for dichotomization of a continuous biomarker, using either maximally selected chi-square statistic or a ROC curve, specifically the Youden Index. In this paper, we explained...

Personalized policy represents a paradigm shift one decision rule for all users to an individualized decision rule for each user. Developing personalized policy in mobile health applications imposes challenges. First, for lack of adherence, data from each user are limited. Second, unmeasured contextual factors can potentially impact on decision making. Aiming to optimize immediate rewards, we propose using a generalized linear mixed modeling framework where population features and individual features are modeled as fixed and...

It was found that bisphenol F (BPF) could be anaerobically transformed to 4,4-dihydroxybenzophenone using nitrate as an electron acceptor by Pseudomonas sp. LS. However, BPF removal was a slow process under anaerobic conditions. In the present study, effects of graphene oxide (GO) and graphene on the anaerobic transformation of BPF were studied in detail. Results showed that GO (2–10 mg/L) and graphene (2–20 mg/L) could increase the anaerobic biotransformation rate of BPF. For GO-mediated system,...

We conducted a meta-analysis to systematically review the efficacy and safety of pembrolizumab for advanced NSCLC. Databases were searched for randomized controlled trials (RCTs) treated with pembrolizumab till July 2021. Seven RCTs and 3988 patients were included. Our analysis suggests that pembrolizumab was more effective at improving PFS (HR, 0.59; 95% CI: 0.43–0.79; p = 0.0005), OS (HR, 0.65; 95% CI: 0.55–0.76; p ＜ 0.00001) and ORR (RR, 1.85; 95% CI: 1.64–2.09; p ＜ 0.00001)...

Sugar Will Eventually be Exported Transporters (SWEET) proteins function as sugar transporters that play key roles in plant growth, development, and biotic and abiotic stress responses. However, little is known about the SWEET gene family in common bean (Phaseolus vulgaris L.). In this study, 24 putative PvSWEET genes were identified. They can be categorized into four subgroups based on a phylogenetic analysis, exon–intron structure, cis-regulatory elements, and MEME motifs. A collinearity analysis showed that three...

Sugar Will Eventually be Exported Transporters (SWEET) proteins function as sugar transporters that play key roles in plant growth, development, and biotic and abiotic stress responses. However, little is known about the SWEET gene family in common bean (Phaseolus vulgaris L.). In this study, 24 putative PvSWEET genes were identified. They can be categorized into four subgroups based on a phylogenetic analysis, exon–intron structure, cis-regulatory elements, and MEME motifs. A collinearity analysis showed that three...

Co-opetition is an increasingly popular hybrid corporate strategy, combining cooperative competition and competitive cooperation (Bengtsson and Kock, 2014). It offers organisations five commonly utilised co-opetive models, namely strategic alliance, joint venture, franchising, licensing and co-branding, in which business partners work together to achieve mutual goals, as well as compete in a healthy marketing environment (Leitao et al., 2014). The core of co-opetition, known as the value net framework, provides organisations a guideline to create sustainable...

Co-opetition is an increasingly popular hybrid corporate strategy, combining cooperative competition and competitive cooperation (Bengtsson and Kock, 2014). It offers organisations five commonly utilised co-opetive models, namely strategic alliance, joint venture, franchising, licensing and co-branding, in which business partners work together to achieve mutual goals, as well as compete in a healthy marketing environment (Leitao et al., 2014). The core of co-opetition, known as the value net framework, provides organisations a guideline to create sustainable...

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method: supplemental document

In this work, an efficient synthesis of 3-hydroxy chromones was accomplished through oxidative cyclization mediated by lipase. This enzymatic process has salient features of environmental friendliness, mild reaction condition, satisfactory yield, green reusable biocatalyst, and short reaction time. The proposed method expands the application of lipase in organic synthesis.

Additional file 8: Figure S1. The correlation analysis of RNA-seq data.

Additional file 4: Age-specific number of females and standardized life expectancy

Microplastics (MPs) have a tremendous potential to sorb hydrophobic organic contaminants in the soil environment. The effects of MPs in the soil systems, however, remain largely unexplored. The objective of this study was to investigate the impact of polyethylene and polystyrene MPs on the transport of the benzo[a]anthracene (BaA) and benzo[a]pyrene (BaP) in soil matrices. In this study, we investigated the sorption process of BaA and BaP in batch sorption experiments in a laboratory and...

Additional file 2: Figure S2. Selection of the optimal number of clusters.

Additional file 15: Supplementary methods. Description of normalization methods used data normalization.

Additional file 4: Table S2. Performance of the SVM model on tumor types.

Additional file 3. Features of the selected 910 E complete sequences for temporal phylogenic reconstruction covering all spatio-temporal distributions and representing all designated subgenotypes and clades in genotypes I, IV, and V from 5003 DENV-1 strains worldwide.

Additional file 2. Supplementary methods and materials.

Additional file 1: Supplemental Table 1. Hazard ratio of all-cause mortality in the sensitivity analysis. Supplemental Fig. 1. Estimated probability of survival (all-cause mortality) according to depression and earlier-stage CKD status in sensitivity analysis with the definition of CKD as eGFR of 15–59 mL/min/1.73 m2 alone. CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate. Supplemental Fig. 2. Estimated probability of survival (all-cause mortality) according to depression and earlier-stage CKD status in sensitivity analysis with...

Additional file 1. Schematic diagram of data collection.

Supplemental material for Construction of a prognostic classifier and prediction of the immune landscape and immunosuppressive molecules in gliomas based on combination of inflammatory response-related genes and angiogenesis-associated genes by Chunbao Chen, Xue Du, Hongjun Liu, Xingyu Lu, Dong Li and Jian Qi in European Journal of Inflammation

Supplemental material, sj-pdf-2-imr-10.1177_03000605221139667 for Osteoperiosteal decortication and bone grafting combined with wave plating for femoral shaft aseptic atrophic nonunion after intramedullary nailing by Yao Lu, Liang Sun, Qian Wang, Cheng Ren, Yibo Xu, Haobo Ye, Ming Li, Hanzhong Xue, Qiang Huang, Zhong Li, Kun Zhang and Teng Ma in Journal of International Medical Research

Supplemental Material for The impact of comprehensive blood conservation program on major complications after total aortic arch replacement by Weidong Yan, Qiaoni Zhang, Sizhe Gao, Gang Liu, Yuan Teng, Jing Wang, Jian Wang, Boyi Zhou, Shujie Yan, and Bingyang Ji in Perfusion