Planners need to read plans to learn and adapt current practice. Planners may struggle to find time to read and study lengthy planning documents, especially in emerging areas such as climate change and urban resilience. Recently, natural language processing (NLP) has shown promise in processing big textual data. We asked whether planners could use NLP techniques to more efficiently extract useful and reliable information from planning documents. By analyzing 78 resilience plans from the 100...

A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 4: Supplemental Table S4. Primers used for qRT- PCR

Additional file 2: Supplementary Methods: Calculation of NAHR-deletion contribution to disease burden for a specific recessive disorder: modified model specific for NPHP1-2q13, 15q13.3 BP4-BP5, RBM8A-1q21.1 and TBX6-16p11.2.

Additional file 2: Supplemental Table S2. ThesiRNA sequences of NC and siPCSK9

Additional file 12: Fig. S5. Enrichment analysis of DEGs for B. gargarizans metamorphosis. The top 30 GO terms and pathways of significant enrichment for the (A and B) upregulated DEGs and (C and D) downregulated DEGs. The y-axis corresponds to the GO term or KEGG pathway, the x-axis corresponds to the EnrichmentScore, and the size of the point corresponds to the number of differential genes in the term or pathway.

Additional file 1: Table 1. STROBE-nut: An extension of the STROBE statement for nutritional epidemiology.

Additional file 1: Table 1. STROBE-nut: An extension of the STROBE statement for nutritional epidemiology.

Additional file 1: Supplementary Fig. S1. PGA with highly complex structure under SEM. Supplementary Fig. S2. Two other crosslinking methods. Supplementary Fig. S3. The detailed process of fabricating DCDS suture with standardization. Supplementary Fig. S4. The tensile strength of double-layers swim bladder with and without crosslinking.

The supporting material contains data and theoretical derivations that are not given in the manuscript, and it is a supplement to this work.

Supplemental material, sj-docx-2-ine-10.1177_15910199221149563 for Validation of the Charlotte large artery occlusion endovascular therapy outcome score using Viz.ai-derived cerebral blood volume index by Rahul R Karamchandani, Hongmei Yang, Jeremy B Rhoten, Dale Strong, Sagar Satyanarayana and Andrew W Asimos in Interventional Neuroradiology

It is of significance, but still remains a key challenge, to attain excellent sound-absorbing and mechanical properties in a material simultaneously. To overcome this challenge, herein, novel multifunctional microlattice metamaterials based on a hollow truss-plate hybrid design are proposed and then realised by digital light processing 3D printing. Quasi-perfect sound absorption (α > 0.999) and broadband half-absorption have been measured. The sound-absorbing capacity is verified to be based on the designed cascaded Helmholtz-like resonators. Physical...

Supplemental Material for Skilled Nursing Facility Participation in Bundled Payments was Related to Small Increases in Nurse Staffing Levels by Meiling Ying, Helena Temkin-Greener, Caroline P. Thirukumaran, Karen E. Joynt Maddox, Robert G. Holloway, and Yue Li in Journal of Applied Gerontology.

Additional file 8: Fig. S1. Cumulative lipids composition.

Additional file 17: Fig. S10. Identification of organs in DESI-MSI sections. (A–C) Frozen sections selected for DESI-MSI; (D–F) DESI-MSI at a specific mass-to-charge ratio that presents a clear org an position. (a–c) Microscope images of the corresponding parts of A to C. A, D and a representative of the left sagittal sections (sagittal section A); B, E, and b represent the mid-sagittal sections (sagittal section B); C, F, and c represent the horizontal sections (horizontal...

Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes. We previously demonstrated that a Candida albicans F1Fo-ATP synthase α subunit deletion mutant was nonlethal to mice. Here, the potential effects of the F1Fo-ATP synthase α subunit on host inflammatory responses and the mechanism were studied. Compared with wild-type strain, the F1Fo-ATP synthase...

FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become one of the hotspots in current pharmaceutical research to solve above problems. Herein, we designed and synthesised a series of FAK-targeting PROTACs consisted of PF-562271 derivative 1 and Pomalidomide. All compounds showed significant in vitro FAK kinase inhibitory activity, the IC50 value of...

FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become one of the hotspots in current pharmaceutical research to solve above problems. Herein, we designed and synthesised a series of FAK-targeting PROTACs consisted of PF-562271 derivative 1 and Pomalidomide. All compounds showed significant in vitro FAK kinase inhibitory activity, the IC50 value of...

Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide...

Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide...

The continued evolution and emergence of novel influenza viruses in wild and domestic animals poses an increasing public health risk. Two human cases of H3N8 avian influenza virus infection in China in 2022 have caused public concern regarding the risk of transmission between birds and humans. However, the prevalence of H3N8 avian influenza viruses in their natural reservoirs and their biological characteristics are largely unknown. To elucidate the potential threat of H3N8 viruses, we analyzed...

Emerging zoonoses of wildlife origin caused by previously unknown agents are one of the most important challenges for human health. The Qinghai-Tibet Plateau represents a unique ecological niche with diverse wildlife that harbors several human pathogens and numerous previously uncharacterized pathogens. In this study, we identified and characterized a novel arenavirus (namely, plateau pika virus, PPV) from plateau pikas (Ochotona curzoniae) on the Qinghai-Tibet Plateau by virome analysis. Isolated PPV strains could replicate in several...

A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 3: Supplemental Table S3. Plasmid sequence of PCSK9

Additional file 6.