Additional file 1. Detailed methods or results covered in this article.

Additional file 2: Table S2. Comparison of clinical outcomes between single first-line and repeated first-line treatment subgroups in rituximab cohort

Additional file 3: Table S3. Comparison of clinical outcomes between early and delayed initiation of rituximab subgroups in rituximab cohort

Additional file 4: Fig. S1. Expressed lncRNAs in two crosses.

Additional file 5: Fig. S2. Expression levels of lncRNAs and PCgenes in sunflower endosperm.

Additional file 7: Fig. S4. DNA methylation profiles of protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Gustatory systems in phytophagous insects are used to perceive feeding stimulants and deterrents, and are involved in insect decisions to feed on particular plants. During the process, gustatory receptors (Grs) can recognize diverse phytochemicals and provide a molecular basis for taste perception. The silkworm, as a representative Lepidoptera species, has developed a strong feeding preference for mulberry leaves. The mulberry-derived flavonoid glycoside, isoquercetin, is required to induce feeding behaviours. However, the corresponding Grs for isoquercetin...

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

Supplement 1

A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 1: Table S1. Sequences of siRNAs. Table S2. Primers for ChIP analysis.

Additional file 1: Table S1. Sequences of siRNAs. Table S2. Primers for ChIP analysis.

Supplemental Material for Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients by Zi-Ye Yan, Wan-Qin Hu, Qi-Qun Zong, Guang-Hui Yu, Chun-Xia Zhai, Lin-Lin Wang, Yu-Hua Wang, Ting-Yu Zhang, Zhen Li, Ying Teng, Jing Cai, Yang-Fan Chen, Mu Li, Zhou-Zhou Xu, Fa-Ming Pan, Hai-Feng Pan, Hong Su, and Yan-Feng Zou in Lupus.

Additional file 3: Supplemental Table S3. Plasmid sequence of PCSK9

Additional file 6.

Additional file 2: Figure S2. The microbial relative abundance of proximal, distal tumor tissues and matched non-tumor tissues at the genus level. Proximal T,proximal GC tumor tissues; Proximal N,proximal GC non-tumor tissues; Distal T, distal GC tumor tissues; Distal N, distal GC non-tumor tissues.

Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

Additional file 1: Fig. S1. Conditions for bulk RNA. Fig. S2. Improved performance of SHERRY2 on bulk RNA. Fig. S3. Conditions for single cells. Fig. S4. Accuracy of SHERRY2 for single cells. Fig. S5. Flow cytometry gating of single lymphocytes and single GC B cells. Fig. S6. DNase activity and performance in SHERRY2 library construction. Fig. S7. GC information gained from SHERRY2. Fig. S8. BCR sequences of single GC B cells identified by SHERRY2. Fig....

Additional file 1.

Simulation code provided according to comments from Reviewers #2 and #3

Additional file1: eFigure 1. Flow chart of enrollment. eTable 1. Multivariate Analysis for preoperative deep venous thrombosis. eTable 2. Patient Characteristics Before and After Propensity Score Matching by Glucose Level (≥6.10 mmol/L and <6.10mmol/L). eTable 3. Patient Characteristics Before and After Propensity Score Matching by Glucose Level (Group1 [0.00-5.30] vs Group2 [5.30-5.70] mmol/L). eTable 4. Patient Characteristics Before and After Propensity Score Matching by Glucose Level (Group2 [5.30-5.70] vs Group3 [5.70-6.60] mmol/L). eTable 5. Patient...

Additional file1: eFigure 1. Flow chart of enrollment. eTable 1. Multivariate Analysis for preoperative deep venous thrombosis. eTable 2. Patient Characteristics Before and After Propensity Score Matching by Glucose Level (≥6.10 mmol/L and <6.10mmol/L). eTable 3. Patient Characteristics Before and After Propensity Score Matching by Glucose Level (Group1 [0.00-5.30] vs Group2 [5.30-5.70] mmol/L). eTable 4. Patient Characteristics Before and After Propensity Score Matching by Glucose Level (Group2 [5.30-5.70] vs Group3 [5.70-6.60] mmol/L). eTable 5. Patient...

Additional file 1. Schematic diagram of data collection.

Purpose: Understanding the mechanism of brain functional alterations in rectal cancer (RC) patients is of great significance to improve the prognosis and quality of life of patients. Additionally, the influence of chemotherapy on brain function in RC patients is still unclear. In this study, we aimed to investigate the alterations of brain functional network dynamics in RC patients and explore the effects of chemotherapy on temporal dynamics of dynamic functional connectivity (DFC). Methods: The group...

A novel calix[6] arene polymer stationary phase (C6A-PEG) is reported that combines the π-electron-rich cavity of calix[6] arene (C6A) with polyethylene glycol (PEG) units for gas chromatography (GC). Thermogravimetric analysis revealed a 5% weight loss of C6A-PEG at 318 °C, and its static-coated capillary column showed high efficiency of 2924 plates/m (k = 3.48) determined by 1-octanol at 120 °C. As a result, the moderate polar C6A-PEG column showed clearly advantageous performance for the Grob...