63 Works

Ensemble and calibration multiply robust estimation for quantile treatment effect

Xiaohong He & Lei Wang
Quantile treatment effects can be important causal estimands in the evaluation of biomedical treatments or interventions for health outcomes such as birthweight and medical cost. However, the existing estimators require either a propensity score model or a conditional density vector model is correctly specified, which is difficult to verify in practice. In this paper, we allow multiple models for propensity score and conditional density vector, then construct a class of calibration estimators based on multiple...

Sex difference in lipid levels in first-diagnosed drug-naïve depression patients: A case-control and 12-weeks follow-up study

Rui Yang, Lu Wang, Song Cao, Ming Chen, Chu-Jun Wu, Floyd Silva, Man-Jun Shen, Jin-Dong Chen, Mi-Mi Tang & Bi-Lian Liu
Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included. The study included 56 healthy controls (males/females = 26/30) and 110 first-diagnosed drug-naïve outpatients (males/females = 35/75). A total of...

Hepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models

Junyu Lin, Jing Li, Peilin Xie, Yue Han, Demin Yu, Jia Chen & Xinxin Zhang
Hepatitis B virus (HBV) middle surface antigen (MHBs) mutation or deletion occurs in patients with chronic HBV infection. However, the functional role of MHBs in HBV infection is still an enigma. Here, we reported that 7.33% (11/150) isolates of CHB patients had MHBs start codon mutations compared with 0.00% (0/146) in acute hepatitis B (AHB) patients. Interestingly, MHBs loss accounted for 11.88% (126/1061) isolates from NCBI GenBank, compared with 0.09% (1/1061) and 0.00% (0/1061) for...

Four new polyprenylated acylphloroglucinol derivatives from Hypericum beanii

Xin-Yue Suo, Xiao-Yu Liu, Xiao-Wei Liu, Xiao-Xiu Li, Ting-Ting Zhu, Teng-Fei Ji & Bo Liu
Two new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbeanins P-Q (1-2), and two new biosynthetic precursors, hyperbeanins R-S (3-4), were isolated from Hypericum beanii, together with three known analogs (5-7). Compound 1 was one of type A PPAPs featured with unusual bicyclo[5.3.1]hendecane core. The structures of isolates were established by NMR spectroscopic methods, experimental electronic circular dichroism (ECD) spectra and comparisons with known compounds. Compounds 5 and 6 showed obvious hepatoprotective activity at 10 µM against paracetamol-induced...

A new dihydroflavone and a new polyacetylene glucoside from Bidens parviflora

Fu-Jie Cai, Chuan-Hou Li, Xiao-Hui Sun, Lu Wang, Jin-Li Tian, Wei Zhao, De-Gang Kong, Qing Liu & Hong-Lei Zhou
A new dihydroflavone, 2(S)-isookanin-4′-methoxy-8-O-β-D-glucopyranoside (1), and a new polyacetylene glucoside, (10S)-tridecane-2E-ene-4,6,8-triyne-1-ol-10-O-β-D-glucopyranoside (2), along with seven known compounds (3–9), were isolated from the herb of Bidens parviflora Willd. The structures of all the extracted compounds were elucidated by HR-ESI-MS, 1 D and 2 D NMR spectra, as well as circular dichroism (CD).

sj-pdf-1-jfi-10.1177_0192513X211041992 – Supplemental Material for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender

Jing Zhang, Tineke Fokkema & Bruno Arpino
Supplemental Material, sj-pdf-1-jfi-10.1177_0192513X211041992 for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender by Jing Zhang, Tineke Fokkema and Bruno Arpino in Journal of Family Issues

Expression analysis of the NR5A2 gene and associations between its polymorphisms and reproductive traits in Jiaxing Black sows

Qiangqiang Chen, Jianfeng Cai, Wei Zhang, Lixia Xiao, Guoliang Liu, Haihong Li, Fen Wu, Qianqian Song, Kui Li & Jinzhi Zhang
This study’s aim was to detect NR5A2 expression and explore association between single nucleotide polymorphism (SNP) of the NR5A2 gene with reproductive traits in Jiaxing Black (JXB) sows. The expression analysis showed that the expression level of pig NR5A2 mRNA in the ovary and liver was significantly higher (p < 0.01) compared to other tissues. 10 SNPs were detected in the exons of NR5A2, and five SNPs (g.136706A > T, g.84609G > A, g.136759G >...

Expression analysis of the NR5A2 gene and associations between its polymorphisms and reproductive traits in Jiaxing Black sows

Qiangqiang Chen, Jianfeng Cai, Wei Zhang, Lixia Xiao, Guoliang Liu, Haihong Li, Fen Wu, Qianqian Song, Kui Li & Jinzhi Zhang
This study’s aim was to detect NR5A2 expression and explore association between single nucleotide polymorphism (SNP) of the NR5A2 gene with reproductive traits in Jiaxing Black (JXB) sows. The expression analysis showed that the expression level of pig NR5A2 mRNA in the ovary and liver was significantly higher (p < 0.01) compared to other tissues. 10 SNPs were detected in the exons of NR5A2, and five SNPs (g.136706A > T, g.84609G > A, g.136759G >...

Foliar nutrient diagnosis norms for litchi (Litchi chinensis Sonn. cv. Feizixiao) in South China

Donglin Luo, Wei Wang, Cuihua Bai, Luwei Zhu, Huan Li, Changmin Zhou, Quanmin Qiu & Lixian Yao
Foliar nutrient diagnosis is a potent tool for nutrient management in crops. Litchi (Litchi chinensis Sonn.) plantation in China dominates the worldwide litchi cultivation, and Feizixiao is the most widely cultivated species in China. Herein, 538 leaf samples were collected at fruit swelling stage and the terminal shoot maturing stage during 2016–2017, and the fruit yields of all the sampled trees were recorded. The suitability of four nutrient diagnosis methods including critical value approach (CVA),...

Four new cembranoids from the South China Sea soft coral Sarcophyton trocheliophorum

Lu Ren, Xue Leng, Te Li, Jing Liu, Wei Wang, Xiaojun Yan, Xia Yan & Shan He
Four new cembrane diterpenes, 1,13-di-epi-13-acetoxy launine P (1), 13-oxo-thunbergol (2), isocrassumol B (3) and 7α, 8α-sarcophine (4), together with two known launine P (5) and sarcophytonin B (6), were isolated from the extract of the South China Sea soft coral Sarcophyton trocheliophorum. The structures were elucidated by spectroscopic analysis, ECD analysis and comparison with literature data. All compounds were tested for their antimicrobial activity and antiviral activity. Compounds 1, 2 and 5 were found to...

Two new sesquiterpenoid lactone derivatives from Lindera aggregata

Song-Song Wen, Yan Wang, Jia-Ping Xu, Qi Liu, Lei Zhang, Jing Zheng, Lin Li, Na Zhang, Xin Liu, Yu-Wen Xu & Zhen-Liang Sun
Two new sesquiterpenoid lactone derivatives, linderin A (1) and linderin B (2) comprising a sesquiterpenoid lactone and a methyl geranylhomogentisate moiety together with six known compounds were isolated from the roots of Lindera aggregata. Their chemical structures were elucidated using extensive spectroscopic analysis including 1 D, 2 D NMR, and HR-ESI-MS data and compared with previously reported data. The absolute configurations of 1 and 2 were assigned based on the electronic circular dichroism calculation. Compound...

Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer

Yizeng Fan, Tao Hou, Yang Gao, Weichao Dan, Tianjie Liu, Bo Liu, Yule Chen, Hongjun Xie, Zhao Yang, Jiaqi Chen, Jin Zeng & Lei Li
Aberrant chaperone-mediated autophagy (CMA) activation has been suggested as a tumorigenesis-promoting event in various cancers, although its roles in prostate cancer (PCa) remain elusive. Emerging evidence indicates that TPD52 isoform 1, a prostate-specific and androgen-responsive gene, contributes to the malignant progression of PCa. Here, we demonstrate that TPD52 enhances CMA activation by interacting with HSPA8/HSC70 and enhancing substrate degradation in PCa. Elevation of TPD52 is essential for CMA-induced PCa cell proliferation and stress resistance in...

Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer

Yizeng Fan, Tao Hou, Yang Gao, Weichao Dan, Tianjie Liu, Bo Liu, Yule Chen, Hongjun Xie, Zhao Yang, Jiaqi Chen, Jin Zeng & Lei Li
Aberrant chaperone-mediated autophagy (CMA) activation has been suggested as a tumorigenesis-promoting event in various cancers, although its roles in prostate cancer (PCa) remain elusive. Emerging evidence indicates that TPD52 isoform 1, a prostate-specific and androgen-responsive gene, contributes to the malignant progression of PCa. Here, we demonstrate that TPD52 enhances CMA activation by interacting with HSPA8/HSC70 and enhancing substrate degradation in PCa. Elevation of TPD52 is essential for CMA-induced PCa cell proliferation and stress resistance in...

POU class 2 homeobox associating factor 1 (POU2AF1) participates in abdominal aortic aneurysm enlargement based on integrated bioinformatics analysis

Jinze Meng, Hao Wen, Xintong Li, Boyang Luan, Shiqiang Gong, Jie Wen, Yifei Wang & Lei Wang
Abdominal aortic aneurysm (AAA) is life-threatening, its natural course is progressively sac expansion and rupture. Elegant studies have been conducted to investigate the molecular markers associated with AAA growth and expansion, this topic however, still needs to be further elucidated. This study aimed to identify potential genes for AAA growth and expansion based on comprehensive bioinformatics approaches. Firstly, 29 up-regulated genes were identified through DEGs analysis between large AAA and small AAA in GSE57691. Secondly,...

β-galactosidase GALA from Bacillus circulans with high transgalactosylation activity

Yaru Yan, Weishi Guan, Xiaoyi Li, Kaier Gao, Xinxin Xu, Bo Liu, Wei Zhang & Yuhong Zhang
β-galactosidase catalyzes lactose hydrolysis and transfers reactions to produce prebiotics such as galacto-oligosaccharides (GOS) with potential applications in the food industry and pharmaceuticals. However, there is still a need for improved transgalactosylation activity of β-galactosidases and reaction conditions of GOS production in order to maximize GOS output and reduce production costs. In this study, a β-galactosidase gene, galA, from Bacillus circulans was expressed in Pichia pastoris, which not only hydrolyzed lactose but also had strong...

The interaction between N and P addition on grassland soil acid buffering capacity is regulated by precipitation

Zhan Shi, Jacob Weiner, Andrea Cavalieri, Heyong Liu, Tianpeng Li, Jiangping Cai & Yong Jiang
Soil acidification induced by nitrogen (N) deposition has important effects on species diversity and ecosystem function. The potential role of phosphorous (P) limitation on these effects was overlooked and observed only after decades of atmospheric N deposition. Few studies have addressed the long-term effect of P addition on soil acidification resulting from N deposition. Changes in precipitation patterns could also have important effects on soil acidification in semi-arid regions. To investigate the effects of long-term...

Sex Difference in Lipid Levels in First-Diagnosed Drug-Naïve Depression Patients: A Case-Control and 12-Weeks Follow-up Study

Rui Yang, Lu Wang, Song Cao, Ming Chen, Chu-Jun Wu, Floyd Silva, Man-Jun Shen, Jin-Dong Chen, Mi-Mi Tang & Bi-Lian Liu
Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included. The study included 56 healthy controls (males/females =26/30) and 110 first-diagnosed drug-naïve outpatients (males/females =35/75). A total of 42 patients...

Foliar nutrient diagnosis norms for litchi (Litchi chinensis Sonn. cv. Feizixiao) in South China

Donglin Luo, Wei Wang, Cuihua Bai, Luwei Zhu, Huan Li, Changmin Zhou, Quanmin Qiu & Lixian Yao
Foliar nutrient diagnosis is a potent tool for nutrient management in crops. Litchi (Litchi chinensis Sonn.) plantation in China dominates the worldwide litchi cultivation, and Feizixiao is the most widely cultivated species in China. Herein, 538 leaf samples were collected at fruit swelling stage and the terminal shoot maturing stage during 2016–2017, and the fruit yields of all the sampled trees were recorded. The suitability of four nutrient diagnosis methods including critical value approach (CVA),...

A new dihydroflavone and a new polyacetylene glucoside from Bidens parviflora

Fu-Jie Cai, Chuan-Hou Li, Xiao-Hui Sun, Lu Wang, Jin-Li Tian, Wei Zhao, De-Gang Kong, Qing Liu & Hong-Lei Zhou
A new dihydroflavone, 2(S)-isookanin-4′-methoxy-8-O-β-D-glucopyranoside (1), and a new polyacetylene glucoside, (10S)-tridecane-2E-ene-4,6,8-triyne-1-ol-10-O-β-D-glucopyranoside (2), along with seven known compounds (3–9), were isolated from the herb of Bidens parviflora Willd. The structures of all the extracted compounds were elucidated by HR-ESI-MS, 1 D and 2 D NMR spectra, as well as circular dichroism (CD).

Four new polyprenylated acylphloroglucinol derivatives from Hypericum beanii

Xin-Yue Suo, Xiao-Yu Liu, Xiao-Wei Liu, Xiao-Xiu Li, Ting-Ting Zhu, Teng-Fei Ji & Bo Liu
Two new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbeanins P-Q (1-2), and two new biosynthetic precursors, hyperbeanins R-S (3-4), were isolated from Hypericum beanii, together with three known analogs (5-7). Compound 1 was one of type A PPAPs featured with unusual bicyclo[5.3.1]hendecane core. The structures of isolates were established by NMR spectroscopic methods, experimental electronic circular dichroism (ECD) spectra and comparisons with known compounds. Compounds 5 and 6 showed obvious hepatoprotective activity at 10 µM against paracetamol-induced...

Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu & Rui Li
Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of C. phaeocaulis through zebrafish and rat models. Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed C. phaeocaulis. Meanwhile,...

Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu & Rui Li
Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of C. phaeocaulis through zebrafish and rat models. Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed C. phaeocaulis. Meanwhile,...

Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma

Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan & Lu Wang
RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patients were evaluated using The Cancer Genome Atlas database. RBM25 was overexpressed in HCC patients compared with the healthy group. The high expression of RBM25 in tumor tissues was significantly...

Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses

Congcong Li, Chaoxi Chen, Yucai Wei, Min Tan, Shuo Zhai, Juebo Zhao, Lu Wang & Tao Dai
It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery. In this study, we modified γ-CD-MOF with span-85 to fabricate the SP-γ-CD-MOF as animal vaccine adjuvants. The ovalbumin (OVA) as the model antigen was...

Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release

Yucai Wei, Chaoxi Chen, Shuo Zhai, Min Tan, Juebo Zhao, Xiaowen Zhu, Lu Wang, Qun Liu & Tao Dai
We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic framework was developed using γ-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin) was primarily encapsulated into the pore structures of γ-CD-MOF, which allowed the sustained release of antibiotics over an extended period of time in vitro and in vivo. Notably, antibiotics-loaded γ-CD-MOF showed much superior activity against bacteria than free...

Registration Year

  • 2021
    63

Resource Types

  • Text
    63

Affiliations

  • Beihang University
    63
  • Shanghai Jiao Tong University
    55
  • Zhejiang University
    51
  • Sun Yat-sen University
    49
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    47
  • Huazhong University of Science and Technology
    43
  • Fudan University
    42
  • First Affiliated Hospital of Xi'an Jiaotong University
    41
  • Sichuan University
    38
  • Shandong University
    38