68 Works

Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer

Jie Wang & Chen Zhang
Cervical cancer is one of the most common causes of cancer deaths in women due to poor prognosis and high mortality rates. A novel mRNA-miRNA-lncRNA signature linked to prognosis of cervical cancer is needed to help clinicians judge the prognosis of individual patients more accurately. On the basis of GEO datasets, a total of 161 upregulated and 242 downregulated DE-mRNAs were identified firstly. Among them, eight potential biomarkers were found to have prognostic values with...

Constructing a new prognostic signature of gastric cancer based on multiple data sets

Liqiang Zhou, Hao Lu, Fei Zeng, Qi Zhou, Shihao Li, You Wu, Yiwu Yuan & Lin Xin
In order to explore new prediction methods and key genes for gastric cancer. Firstly, we downloaded the 6 original sequencing data of gastric cancer on the Illumina HumanHT-12 platform from Array Expression and Gene Expression Omnibus, and used bioinformatics methods to identify 109 up-regulated genes and 271 down-regulated genes. Further, we performed univariate Cox regression analysis of prognostic-related genes, then used Lasso regression to remove collinearity, and finally used multivariate Cox regression to analyze independent...

Constructing a new prognostic signature of gastric cancer based on multiple data sets

Liqiang Zhou, Hao Lu, Fei Zeng, Qi Zhou, Shihao Li, You Wu, Yiwu Yuan & Lin Xin
In order to explore new prediction methods and key genes for gastric cancer. Firstly, we downloaded the 6 original sequencing data of gastric cancer on the Illumina HumanHT-12 platform from Array Expression and Gene Expression Omnibus, and used bioinformatics methods to identify 109 up-regulated genes and 271 down-regulated genes. Further, we performed univariate Cox regression analysis of prognostic-related genes, then used Lasso regression to remove collinearity, and finally used multivariate Cox regression to analyze independent...

Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu & Rui Li
Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of C. phaeocaulis through zebrafish and rat models. Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed C. phaeocaulis. Meanwhile,...

Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu & Rui Li
Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of C. phaeocaulis through zebrafish and rat models. Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed C. phaeocaulis. Meanwhile,...

The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial

Zhong-Ping Gou, Yun-Li Zhao, Lin-Ling Zou, Ying Wang, Shi-Qing Shu, Xiao-Hong Zhu, Li Zheng, Qi Shen, Zhu Luo, Jia Miao, Yong-Sheng Wang, Xiao-Dong Luo & Ping Feng
Capsule of alkaloids from the leaf of Alstonia scholaris (L.) R.Br. (Apocynaceae) (CALAS) is a new investigational botanical drug (No. 2011L01436) for bronchitis, post-infectious cough and asthma. To observe the clinical safety and tolerability of CALAS. Subjects were assigned to eight cohorts, and each received randomly CALAS or placebo in one of single ascending dose (SAD) of 8, 40, 120, 240, 360, 480, or in one of multiple ascending dose (MAD) of 40 or 120...

Biosynthesized CuO as a Green and Efficient Nanophotocatalyst in the Solvent-Free Synthesis of Some Chromeno[4, 3-b]Chromenes. Studying anti- Gastric Cancer Activity

Juan Liu, Jun Wang, Effat Esmaeili, Nasrin Mollania, Hengameh Atharifar, Maryam Keywanlu & Reza Tayebee
Gastric cancer is a foremost one among many regular carcinoma cases globally and most of the enhanced treatments could not significantly decrease the mortality range of this cancer. The current work is planned to develop a new rote for the synthesis of a nanophotocatalyst and substituted chromenones that are effective drugs against gastric cancer. Thus, CuO as a new heterogeneous green nanophotocatalyst is biosynthesized from Cressa leaf extract and the prepared nanophotocatalyst is applied in...

LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling

Min Sun, Yanan Chen, Xiaobei Liu & Yajie Cui
Ovarian cancer (OC) brings about serious physical and psychological burden for female patients. LncRNA CASC9 has been reported to be intimately linked with the occurrence and development of several tumors. However, the biological role of lncRNA CASC9 in OC still lacks sufficient evidence. The expressions of CASC9 and miR-488-3p in OC cell lines and xenograft mice were detected by qRT-PCR assay. Cell Counting Kit-8 (CCK-8) assay was used to assess cell inhibition rate and cell...

LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling

Min Sun, Yanan Chen, Xiaobei Liu & Yajie Cui
Ovarian cancer (OC) brings about serious physical and psychological burden for female patients. LncRNA CASC9 has been reported to be intimately linked with the occurrence and development of several tumors. However, the biological role of lncRNA CASC9 in OC still lacks sufficient evidence. The expressions of CASC9 and miR-488-3p in OC cell lines and xenograft mice were detected by qRT-PCR assay. Cell Counting Kit-8 (CCK-8) assay was used to assess cell inhibition rate and cell...

Additional file 1 of Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Xiaofen Ruan, Yiping Li, Yuanlong Sun, Meijun Jia, Xiaowen Xu, Li Huo, Wei Song, Yili Yao & Xiaolong Wang
Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*.

Long noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms

Lei Zhang, Xinxin Zheng, Jun Li, Guoqing Wang, Zenglei Hu, Yu Chen, Xiaoquan Wang, Min Gu, Ruyi Gao, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Jiao Hu & Xiufan Liu
A growing body of evidence suggests the pivotal role of long non-coding RNA (lncRNA) in influenza virus infection. Based on next-generation sequencing, we previously demonstrated that Lnc45 was distinctively stimulated by H5N1 influenza virus in mice. In this study, we systematically investigated the specific role of Lnc45 during influenza A virus (IAV) infection. Through qRT-PCR, we first demonstrated that Lnc45 is highly up-regulated by different subtypes of IAV strains, including H5N1, H7N9, and H1N1 viruses....

Insights into small molecule inhibitor bindings to PD-L1 with residue-specific binding free energy calculation

Wei Xia, Liping He, Jingxiao Bao, Yifei Qi & John Z.H. Zhang
Targeting the immunological checkpoint PD-1/PD-L1 with antibodies has shown opportunities to improve cancer treatment in recent years. However, antibody therapy is a double-edged sword with high cost, low patient tolerance, lack of oral bioavailability, and a reaction to most solid tumors that prevents the adoption of antibodies. Advancement of small-molecule PD-1/PD-L1 inhibitors that could overwhelm these drawbacks is sluggish because of the poor pharmacodynamic properties and shallow pocket of the PD-1/PD-L1 binding interface. Recently, a...

A new prognostic risk model based on autophagy-related genes in kidney renal clear cell carcinoma

Guangzhen Wu, Yingkun Xu, Huayu Zhang, Zihao Ruan, Peizhi Zhang, Zicheng Wang, Han Gao, Xiangyu Che, Qinghua Xia & Feng Chen
This study aimed to explore the potential role of autophagy-related genes in kidney renal clear cell carcinoma (KIRC) and develop a new prognostic-related risk model. In our research, we used multiple bioinformatics methods to perform a pan-cancer analysis of the CNV, SNV, mRNA expression, and overall survival of autophagy-related genes, and displayed the results in the form of heat maps. We then performed cluster analysis and LASSO regression analysis on these autophagy-related genes in KIRC....

Early Cretaceous rapid exhumation processes in the southern Great Xing’an Range, NE China: implications for extensional geodynamics

Wen Chen, Wen Zhang, Shuangfeng Zhao, Jingbo Sun, Ze Shen, Qiuyi Du & Zhi Li
The Mesozoic-Cenozoic geological evolution of the southern Great Xing’an Range (GXR) has long been controversial since it is located in the superposed region of different tectonic regimes and involves complex interactions. Here, we present low-temperature thermochronological data from granitoids emplaced in multiple magmatic stages to delineate the tectono-thermal history and further understand the geodynamic process. Most zircon and apatite (U-Th)/He ages, within error, indicate Early Cretaceous: the zircon average (U-Th)/He ages range from 146.7 ±...

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Lan-Qing Li, Jing Li, Hong-Ping Long, Ji-Kai Liu & Xian Wang
Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1–3 against the damage of PC12...

Additional file 1 of Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Xiaofen Ruan, Yiping Li, Yuanlong Sun, Meijun Jia, Xiaowen Xu, Li Huo, Wei Song, Yili Yao & Xiaolong Wang
Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*.

Two new sesquiterpenoid lactone derivatives from Lindera aggregata

Song-Song Wen, Yan Wang, Jia-Ping Xu, Qi Liu, Lei Zhang, Jing Zheng, Lin Li, Na Zhang, Xin Liu, Yu-Wen Xu & Zhen-Liang Sun
Two new sesquiterpenoid lactone derivatives, linderin A (1) and linderin B (2) comprising a sesquiterpenoid lactone and a methyl geranylhomogentisate moiety together with six known compounds were isolated from the roots of Lindera aggregata. Their chemical structures were elucidated using extensive spectroscopic analysis including 1 D, 2 D NMR, and HR-ESI-MS data and compared with previously reported data. The absolute configurations of 1 and 2 were assigned based on the electronic circular dichroism calculation. Compound...

Single-machine scheduling with energy generation and storage systems

Hyun-Jung Kim, Eun-Seok Kim, Jun-Ho Lee, Lixin Tang & Yang Yang
This paper considers a single-machine scheduling problem with sequence-dependent setup times and energy-generation and storage systems. Each job requires a sequence-dependent setup to be processed on the machine, and both setup and processing of the job require job-dependent amounts of energy. The energy consumed by the machine can be bought from an Electric Power Company (EPC) or generated by own Distributed Energy Resource (DER), such as solar photovoltaic or wind, and the energy can be...

Effect of Spray Properties on Aerosol Scavenging Efficiency with Water Mist

Hui Liang, Qian Zhou, Nejdet Erkan & Shunichi Suzuki
In the foreseen decommissioning plans of damaged Fukushima Daiichi reactors, submicron aerosol particles will be generated when retrieving fuel debris from reactor buildings by cutting it into small pieces. A multi-nozzle spray system will be used to scavenge these aerosol particles inside the primary containment vessel. To improve the aerosol removal efficiency of the multi-nozzle spray system, it is now necessary to study the aerosol removal performance by different single spray nozzles with different spray...

Effect of spray properties on aerosol scavenging efficiency with water mist

Hui Liang, Qian Zhou, Nejdet Erkan & Shunichi Suzuki
In the foreseen decommissioning plans of damaged Fukushima Daiichi reactors, submicron aerosol particles will be generated when retrieving fuel debris from reactor buildings by cutting it into small pieces. A multi-nozzle spray system will be used to scavenge these aerosol particles inside the primary containment vessel. To improve the aerosol removal efficiency of the multi-nozzle spray system, it is now necessary to study the aerosol removal performance by different single spray nozzles with different spray...

Discovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure

Jiying Chen, Qinger Zhou, Yonggang Zhang, Wenqing Tan, Hanchao Gao, Liying Zhou, Shuixiu Xiao, Jinhua Gao, Jing Li & Zhiying Zhu
Several widely recognized metabolites play a role in regulating the pathophysiological processes of various disorders. Nonetheless, the lack of effective biomarkers for the early diagnosis of polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF) has led to the discovery of serum-based metabolic biomarkers for these disorders. We aimed to identify various differentially expressed metabolites (DEMs) through serum-based metabolic profiling in patients with PCOS and POF and in healthy individuals by using liquid chromatography–mass spectrometry...

Biosynthesized CuO as a Green and Efficient Nanophotocatalyst in the Solvent-Free Synthesis of Some Chromeno[4, 3-b]Chromenes. Studying anti- Gastric Cancer Activity

Juan Liu, Jun Wang, Effat Esmaeili, Nasrin Mollania, Hengameh Atharifar, Maryam Keywanlu & Reza Tayebee
Gastric cancer is a foremost one among many regular carcinoma cases globally and most of the enhanced treatments could not significantly decrease the mortality range of this cancer. The current work is planned to develop a new rote for the synthesis of a nanophotocatalyst and substituted chromenones that are effective drugs against gastric cancer. Thus, CuO as a new heterogeneous green nanophotocatalyst is biosynthesized from Cressa leaf extract and the prepared nanophotocatalyst is applied in...

Long noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms

Lei Zhang, Xinxin Zheng, Jun Li, Guoqing Wang, Zenglei Hu, Yu Chen, Xiaoquan Wang, Min Gu, Ruyi Gao, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Jiao Hu & Xiufan Liu
A growing body of evidence suggests the pivotal role of long non-coding RNA (lncRNA) in influenza virus infection. Based on next-generation sequencing, we previously demonstrated that Lnc45 was distinctively stimulated by H5N1 influenza virus in mice. In this study, we systematically investigated the specific role of Lnc45 during influenza A virus (IAV) infection. Through qRT-PCR, we first demonstrated that Lnc45 is highly up-regulated by different subtypes of IAV strains, including H5N1, H7N9, and H1N1 viruses....

Efficacy and safety of pembrolizumab for treating advanced non-small-cell lung cancer: a meta-analysis of phase II and III randomized controlled trials

Tianyao Gong, Lei Liu, Yufei Liu, Ke Liu, Yang Yang, Liuying Li & Chuantao Zhang
We conducted a meta-analysis to systematically review the efficacy and safety of pembrolizumab for advanced NSCLC. Databases were searched for randomized controlled trials (RCTs) treated with pembrolizumab till July 2021. Seven RCTs and 3988 patients were included. Our analysis suggests that pembrolizumab was more effective at improving PFS (HR, 0.59; 95% CI: 0.43–0.79; p = 0.0005), OS (HR, 0.65; 95% CI: 0.55–0.76; p < 0.00001) and ORR (RR, 1.85; 95% CI: 1.64–2.09; p < 0.00001)...

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

Yunhui Hu, Jia Sun, Tongxing Wang, Hairong Wang, Chunlai Zhao, Wenjia Wang, Kaijing Yan, Xijun Yan & He Sun
Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear. To explore the protective effect of CDDP on hypobaric hypoxia (HH) and its possible mechanism. A meta-analysis of 1051 human volunteers was performed to evaluate the effectiveness of CDDP at high altitudes. Male Sprague-Dawley rats were randomized into 5 groups (n = 6): control at normal pressure, model, CDDP-170 mg/kg, CDDP-340 mg/kg...

Registration Year

  • 2021
    68

Resource Types

  • Text
    68

Affiliations

  • Shanghai University of Traditional Chinese Medicine
    68
  • Shanghai Jiao Tong University
    45
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    43
  • Sun Yat-sen University
    37
  • Zhejiang University
    37
  • Huazhong University of Science and Technology
    36
  • Fudan University
    35
  • Chinese Academy of Sciences
    32
  • Sichuan University
    30
  • Southern Medical University
    28