Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy. Methods: Eligible studies were selected from phase II/III randomized controlled trials investigating ICIs. The data were analyzed by R software and Stata. Odds ratio of treatment-related AE (trAEs) and nonspecific ophthalmic trAEs (NS-trAEs) were lower for PD-1/PD-L1...

Supplemental material, sj-pdf-1-prf-10.1177_02676591211031468 for Establishment of a venovenous extracorporeal membrane oxygenation in a rat model of acute respiratory distress syndrome by Yongnan Li, Jian Huang, Rongzhi Zhang, Shixiong Wang, Xingdong Cheng, Pengbin Zhang, Kerong Zhai, Wei Wang, Debin Liu and Bingren Gao in Perfusion

Supplemental material, sj-pdf-1-prf-10.1177_02676591211031468 for Establishment of a venovenous extracorporeal membrane oxygenation in a rat model of acute respiratory distress syndrome by Yongnan Li, Jian Huang, Rongzhi Zhang, Shixiong Wang, Xingdong Cheng, Pengbin Zhang, Kerong Zhai, Wei Wang, Debin Liu and Bingren Gao in Perfusion

Organic contaminants of emerging concern (OCECs) originating from assorted sources have attracted increasing attention latterly as most of them are not under routine surveillance or effective regulation but possess persistent, bioaccumulative, and toxic potential. Massive terrestrial inputs and proximity to intense human activities have elevated OCEC contamination in many estuaries. The present review outlines the current knowledge on the environmental occurrence and fate, as well as bioavailability of nine classes of OCECs, i.e., per- and...

CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 1. Section S1: The specific process of Focal liver lesion puncture biopsy procedure. Section S2: Image archiving and scanning parameters of CT and MRI. Table S1: FLLs with TIV images characteristics. Except where indicated, data are numbers of nodules or TIV cases and numbers in parentheses are percentages. * datas are Mean ± SD. / means NA. AP: Arterial phase; APHE: Arterial phase hyperenhancement; CEUS: Contrast-enhanced ultrasound; FLLs: Focal liver lesions; HCC: Hepatocellular...

Additional file 4: Supplemental Table S4. Primers used for qRT- PCR

Supplementary Material 1

Supplementary Material 2

Additional file 2: Fig. S1. Evolutionary inference of nutrition types for Neottieae. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities of alternative ancestral states obtained by BayesTraits. Fig. S2. Ancestral range reconstruction for Neottieae using BioGeoBEARS under the statistical DEC model. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities...

Additional file 2: Supplemental Table S2. ThesiRNA sequences of NC and siPCSK9

Additional file 1: Supplemental file 1. Study information sheet for patients.

Schemes of PHE and ROS molecular structures; SERS spectra of mixture substances; Accuracies comparison by using different loss functions; Preparation of serum samples

Additional file 3: Figure S2. The microbial relative abundance of proximal, distal tumor tissues and matched non-tumor tissues at the genus level. Proximal T,proximal GC tumor tissues; Proximal N,proximal GC non-tumor tissues; Distal T, distal GC tumor tissues; Distal N, distal GC non-tumor tissues.

Additional file 4: Figure S3. Differential microbiota of gastric cancer tissues and non-tumor tissues. A Differential taxa from phylum to genus of Distal T and Distal N. B Differential taxa from phylum to genus of Proximal T and Proximal N.

Additional file 5: Figure S4. Metabolite composition and difference between Proximal N and Distal N. A, B OPLS-DA showed that Proximal N and Distal N were not separated into two clusters. Test for OPLS-DA model showed that the OPLS-DA model for this study was valid.

Supplementary Material 3

Additional file 1. Analysis and interpretation process of fetal ES data.

Additional file 1: Table S1. Differentially expressed proteins identified in plasma samples.

Additional file 1: Supplementary Fig. S1. PGA with highly complex structure under SEM. Supplementary Fig. S2. Two other crosslinking methods. Supplementary Fig. S3. The detailed process of fabricating DCDS suture with standardization. Supplementary Fig. S4. The tensile strength of double-layers swim bladder with and without crosslinking.

Supplemental material, sj-docx-1-pie-10.1177_09544089221097360 for Sealing mechanism of large size and large deformation rubber cylinder for pipeline intelligent plugging robot under multiple factors by Yang Tang, Yuan Wang, Peng Sun and Xiang Liu in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering

Additional file 1.