Additional file 1: Supplementary Methods. Supplementary Table S1. Clinical characteristics of patients. Supplementary Figure S1. The overview of patients enrolled in this study and the concurrent gene/pathway alterations. (A) A total of 328 colorectal patients whose treatment-naïve tumor samples harboring BRAF mutations from the database are included in this study. (B) The oncoprint of the most frequently concurrent gene mutations (top panel) and pathway alterations (bottom panel) are shown as legend by BRAF classes. Supplementary...

Additional file 1. Factors determining decision of treatment with curative intent in patients with non-metastatic disease. Logistic regression of operated patients and patients with locally advanced disease.

Additional file 1. Figure S1. FGF19 do not significantly change the expressions of mitochondrial fission-related proteins in chondrocytes. Figure S2. Quantitative analysis of western blotting in Fig. 4b indicates that FGF19 induces a higher expression of p-p38 signalling than the other two ones, p-Erk and p-JNK in chondrocytes in the presence of β-Klotho. Figure S3. Inhibition of p38 changes the expression of FGF19-induced mitochondrial fission proteins in chondrocytes. Table S1. RNA sequencing showing the change...

Additional file 7: Table S6. The sequence of the crRNAs and gRNAs used in this study.

Additional file 8. Uncropped western blot images.

Additional file 1. Supplementary tables and figures.

Effects of lipid loading on the hypoxic and post-hypoxic GBM cell secretome. A and B, Maintained effect of lipid loading on protein secretion in reoxygenated, post-hypoxic conditions: GBM cells (U-87 MG) were grown in hypoxia without (LD−) and with LDL (LD+) and then reoxygenated for 6 h (A) and 48 h (B). Shown is linear fold change (FC) of protein levels in LD+ vs LD− cells as determined by proximity extension assay. C and D,...

Additional file 1: Fig. S1. Canopy height correlations between the field measurement and DAP estimates at different flight heights. (a), (b), (c), and (d) are the results of flight height at 10, 20, 30, and 40m, respectively. The solid line represents the fitted line, and the dashed line represents the 1:1 line. The color bar shows the kernel density value of the point distribution, and the green to yellow represents the increase in kernel density....

Additional file 11.

Additional file 1. Information provided to respondents after background questions.

Additional file 2. Additional statistical analyses.

Additional file 1: Comparison between ROTEM® delta and roTEG®.

Additional file 1. Table S1. Association between selected confounders and 5-year mortality and recurrence within 3 years. Univariate analysis. Table S2. Association between selected preoperative variables and postoperative mortality. Univariate analysis.

Additional file 1: eTable 1. List of Identified Manuscripts to be Included in Review includes all citations, reference numbers, and types of assays studied for manuscripts included in the review. eFigure 1. Diagram of Literature Search is a schematic depicting how manuscripts were found for inclusion in this review, including a list of references at each step.

Additional file 1: Table S1. A total of 10 single nucleotide polymorphisms associated with AMY1 copy number. Table S2. Association between intake of AMY1-GRS and CVD and mortality risk (n = 20,264). Table S3. Association between starch intake and plasma proteins (n = 3680). Table S4. Association between plasma proteins and CVD and mortality risk (n = 3680). Table S5. Association between AMY1 copy number and plasma proteins (n = 3254). Figure S1. Flowchart of...

Additional file 1.

Additional file 16: Figure S8. PheWAS meta-analysis results for the trans-ethnic nonHDL-C PGS in UK Biobank and MVP.

Additional file 31: Supplementary Note. Supplementary Note and Cohort Acknowledgments.

Additional file 1: Additional figure 1. Uncropped immunoblots of GAPDH blots. Chemiluminescence channel of C57Bl/6J blot (A), BALB/c blot (C) and C57Bl/6N blot (E). Chemiluminescence and 700 nm channel merge of C57Bl/6J blot (B), BALB/c blot (D) and C57Bl/6N (F), to visualize ladder. Ladder size is indicated.

Additional file 3: Additional figure 3. Uncropped immunoblots of MDA5 blots. Chemiluminescence channel of C57Bl/6J blot (A), BALB/c blot (C) and C57Bl/6N blot (E). Chemiluminescence and 700 nm channel merge of C57Bl/6J blot (B), BALB/c blot (D) and C57Bl/6N (F), to visualize ladder. Ladder size is indicated.

Additional file 5: Additional figure 5. Effect of i.n. dsRNA administration on BALF cellular infiltration in mice. dsRNA (100 µg) or saline were i.n. administered to C57Bl/6J, C57Bl/6N or BALB/c mice once per day for three consecutive days, and the total number of lymphocytes (A), neutrophils (B) and macrophages (C) were determined in BALF using cytospin, differential cell counting and cell concentration measurements. Data are presented as mean ± SD. Differences between groups were tested...

Additional file 24: Figure S9. Comparison of effect size estimates between males and females for index variants showing a significant difference in effect size between sexes.

Additional file 1. SPIRIT 2013 Checklist.

Additional file 2. Experiences of the transfer.

Additional file 4. Consent form for participating in ParTNerSTEPs.