15 Works

Moving Towards Global Solidarity for Global Health through Multilateral Governance in the Covid-19 Response

Judith Bueno de Mesquita & Benjamin Mason Meier

Implications of Asymmetry Risk for Portfolio Analysis and Asset Pricing

Fousseni Chabi-Yo, Dietmar Leisen & Eric Renault
Asymmetric shocks are common in markets; securities' payoffs are not normally distributed and exhibit skewness. This paper studies the portfolio holdings of heterogeneous agents with preferences over mean, variance and skewness, and derives equilibrium prices. A three funds separation theorem holds, adding a skewness portfolio to the market portfolio; the pricing kernel depends linearly only on the market return and its squared value. Our analysis extends Harvey and Siddique's (2000) conditional mean-variance-skewness asset pricing model...

Psychedelics: from pharmacology to phenomenology. An interview with David Nichols.

David Nichols, Leor Roseman & Christopher Timmermann
In this interview, David Nichols – the acknowledged psychedelic pharmacologist - discusses a range of topics about psychedelic research and its relevance for consciousness science. He covers novel findings about psychedelics and their key mechanisms at the receptor level, while debunking old myths and criticize unproven speculations. At the pharmacological level, Nichols expands on two findings that suggest that receptors are not simply on/off switches. The first finding is of a lid shaped structure which...

G-Quadruplex Structure Improves the Immunostimulatory Effects of CpG Oligonucleotides

Kazuaki Hoshi, TOMOHIKO YAMAZAKI, Yuuki Sugiyama, Kaori Tsukakoshi, Wakako Tsugawa, Koji Sode & Kazunori Ikebukuro
Single-strand oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanine (CpG) are recognized by the toll-like receptor 9, a component of the innate immunity. Therefore, they could act as immunotherapeutic agents. Chemically modified CpG ODNs containing a phosphorothioate backbone instead of phosphodiester (PD) were developed as immunotherapeutic agents resistant to nuclease degradation. However, they cause adverse side effects, and so there is a necessity to generate novel CpG ODNs. In the present study, we designed a nuclease-resistant nonmodified CpG...

Add Health Wave V Documentation: Cardiovascular Measures

Eric A. Whistsel, Robert Angel, Rick O'Hara, Lixin Qu, Kathryn Carrier & Kathleen Mullan Harris
This document summarizes the rationale, equipment, measurement, protocol and data cleaning procedures for each of the cardiovascular measures collected at the Wave V home exam. It also documents how constructed variables were derived from the cardiovascular measures collected in the field. Whenever possible, data collection and methods in Wave V mirrored those of Wave IV to ensure comparability of data between waves. This document is one in a set of Wave V user guides. User...

Fruits of Nandina domestica are (Sometimes) Cyanogenic and (Sometimes) Hazardous to Birds

Scott Zona
A 12-month survey of cyanogenesis in the fruits and leaves of Nandina domestica (Berberidaceae) revealed that the leaves are strongly cyanogenic throughout the year, as measured by the Feigl-Anger test. Fruits vary in their cyanogenic potential depending on the degree of ripeness and clone. Green fruits are strongly and rapidly cyanogenic, but most ripe fruits are weakly and slowly cyanogenic. Some fruits tested negative for cyanide. Fruits tend to become less cyanogenic the longer they...

DMT in the Mammalian Brain: A Critical Appraisal

Charles D. Nicholas & David E. Nichols
Recently, a publication from Dean et al. reported that N,N-dimethyl tryptamine (DMT) is synthesized in the rat brain cortex, present at levels similar to other monoamine neurotransmitters, and significantly increases in concentration at death. They further promoted the theory that DMT may serve as the causative agent for “near death experiences”, which have been compared to peak psychedelic experiences. The publication certainly is interesting and suggests additional directions to explore scientifically but does not meet...

The Hispanic/Latino community in the Fox Ridge Manor Apartments, Wake County, North Carolina : an action-oriented community diagnosis : findings and next steps of action

Carolyn Gray, Tasseli McKay, Kisha Merchant, Amanda Phillips-Martinez & Kristin Schaible
During the 2002-2003 academic year, five students from the University of North Carolina’s School of Public Health conducted a community diagnosis for Hispanic/Latino residents of Fox Ridge Manor, an apartment complex in Southeast Raleigh. The AOCD process is used to help understand the many sides of a community, including its norms, values, culture, power structure, history, and patterns of communication (Eng and Blanchard, 1991). The goal is to develop an insider’s view and understanding of...

Latinos in Sampson County, North Carolina : an action-oriented community diagnosis

Rebecca Cashman, Katie Cravens, Amy Hobbie, Tanya Montoya, Serene Myers & Sarah O'Brien
The following document is a detailed report of an Action Oriented Community Diagnosis (AOCD) conducted by a team of six students from the University of North Carolina Chapel Hill, School of Public Health, Department of Health Behavior and Health Educations in collaboration with the Sampson County Health Department. The AOCD was conducted in order to understand the cultural, social, economic, and health experiences of Latinos living in or accessing services in Sampson County. Throughout the...

Spanish-speaking community of Asheboro, Randolph County, North Carolina : an action oriented community diagnosis : findings and recommendations for future action

Kelley De Leeuw, Carrie Fesperman, Mariana Garrettson, Matthew Griffith, Heather Hart & Ann Krier
Asheboro, a small textile-manufacturing city in the southern Piedmont region of North Carolina, is considered a desirable place to live by most of its adult residents. However, the small city has been struggling to keep up with rapid population growth due in part to an influx of Latino immigrants. From 1990 to 2000 the Asheboro Latino population increased by well over 2,000%. This rapid growth has put a strain on social services in the region,...

Non-Response in Wave IV of the National Longitudinal Study of Adolescent Health

Naomi Brownstein, William D. Kalsbeek, Joyce Tabor, Pamela Entzel, Eric Daza & Kathleen Mullan Harris

Evolving constraints and rules in Harmonic Grammar

Elliott Moreton

The Latino community of Carrboro, Orange County, NC : an action-oriented community diagnosis : a participatory assessment of the Latino community of Carrboro

Erica Childs, Stephanie Etienne, Shaina Gross, Kristen Stoimenoff & Nina Yamanis
Carrboro is located adjacent to Chapel Hill, North Carolina and prides itself on being an open and welcoming community. Since 1990 the Latino population of Carrboro has grown 936%, and currently represents 12% of the community. The significant growth of the Latino community of Carrboro has contributed to the town’s diversity and has led to many changes in service delivery. An Action-Oriented Community Diagnosis of the Latino community of Carrboro was conducted by five graduate...

On Portfolio Separation Theorems with Heterogeneous Beliefs and Attitudes towards Risk

Fousseni Chabi-Yo, Eric Ghysels & Eric Renault
The early work of Tobin (1958) showed that portfolio allocation decisions can be reduced to a two stage process: first decide the relative allocation of assets across the risky assets, and second decide how to divide total wealth between the risky assets and the safe asset. This so called twofund separation relies on special assumptions on either returns or preferences. Tobin (1958) analyzed portfolio demand in a mean-variance setting. We revisit the fund separation in...

Tractable Term-Structure Models and the Zero Lower Bound

Bruno Feunou, Jean-Sébastien Fontaine, Anh Le & Christian Lundblad
We greatly expand the space of tractable term-structure models. We consider one example that combines positive yields with rich volatility and correlation dynamics. Bond prices are expressed in closed form and estimation is straightforward. We find that the early stages of a recession have distinct effects on yield volatility. Upon entering a recession when yields are far from the lower bound, (i) the volatility term structure becomes flatter, (ii) the level and slope of yields...

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