Additional file 1: Supplemental Table 1. Comparison of baseline characteristics between survivors and non-survivors. Supplemental Figure 1. Kaplan-Meier plots for cumulative 1-year survival according to early coagulopathy. The difference was statistically significant according to the log-rank test (P <0.001).

Additional file 2: Clinical stage-specific disability weights and distribution of breast cancer in females in China.

Configuration of simulation setup

Additional file 1: Figure S1. The clones of the CAF and CAFR group after 0, 4, 8 and 10 Gy irradiation. Representative dishes after colony-forming assay are shown. Figure S2. The senescence and proliferative capacity of CAF and CAFR. (A) Radiation-induced senescence was detected by a β-galactosidase assay. Blue color, β-gal positive cells. Percentage of β-galactosidase positive cells in each group was calculated and showed in bottom. (B) Cell proliferation curve detected by MTT. Figure...

Supplementary Material 2

Additional file 2: Figure S2. The microbial relative abundance of proximal, distal tumor tissues and matched non-tumor tissues at the genus level. Proximal T,proximal GC tumor tissues; Proximal N,proximal GC non-tumor tissues; Distal T, distal GC tumor tissues; Distal N, distal GC non-tumor tissues.

A chlorosulfonylation of vinylarenes using magnetic metal–organic framework (MOF) composite Cu-BTC@Fe3O4 (BTC = 1,3,5-benzenetricarboxylate) as the catalyst has been developed. This protocol features easily accessible starting materials, good functional group compatibility and simple recovery of the catalyst. The recovered catalyst could be reused for at least successive five runs with only a slight decrease in its catalytic activity.

Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

Acute myeloid leukemia (AML) is the second most common hematological malignancy after lymphoma in the world. Long non-coding RNAs (LncRNAs) have been suggested as key regulators of cancer development and progression in AML. As a member of lncRNA family, the biological role and mechanisms of tyrosine kinase non receptor 2 antisense RNA 1 (TNK2-AS1) in AML is still unclear. The expression of TNK2-AS1 was measured with RT-qPCR in AML cell lines. The changes of the...

Additional file 9: Figure S9. Genome-wide composition of blastocysts following multipolar zygotic division. Circos plots of six embryos that developed to the blastocyst stage following multipolar zygotic division in which each circle represents the interpreted genome constitution per chromosome (1 - X) of a sampled single cell. The interpreted genome spanning the largest part of the chromosome was chosen as overall interpretation per chromosome, as such, segmental chromosomal errors are not depicted. On the left...

Additional file 1: Demographic, breast cancer epidemiological and screening factors of the female populations in China.

Additional file 4: Table S2. Probes sequences targeting NUP188 and PDXDC1 in MLPA. GAPDH served as a internal control

Additional file 4: Table S2. Probes sequences targeting NUP188 and PDXDC1 in MLPA. GAPDH served as a internal control

Additional file 7: Table S3. Primers used for Sanger sequencing for TTC21B and TTC12 variants that identified from WES analyzes

Additional file 7: Table S3. Primers used for Sanger sequencing for TTC21B and TTC12 variants that identified from WES analyzes

Additional file 2: Fig. S1. The phenotypes of WT, Ov-2 and Ov-3 lines. (a) The growing of WT, Ov-2 and Ov-3 lines under control condition. (b) The growing of WT, Ov-2 and Ov-3 lines under RBSDV infection conditions.

Additional file 1.

Additional file 1: Figure S1. Correlation between gene significance and related module membership. A. The correlation between gene significance and module membership in the gray module. B. The correlation between gene significance and module membership in the blue module. *p < 0.05, **p < 0.01, ***p < 0.001.

Additional file 3: Figure S3. Identification of candidate hub genes to predict prognosis for AML patients. A. Partial likelihood deviance for different numbers of variables revealed by the LASSO regression model. Red dots represent the partial likelihood deviance values. Gray lines represent the partial likelihood deviance ± standard error. B. Fourteen candidate genes with minimum lambda values were obtained by LASSO regression with tenfold cross-validation. C. Candidate genes were filtrated from SVM-RFE algorithms. D. Five...

Additional file 4: Figure S4. The expression levels of DLC1, NFIB, DENND5B, TANC2, and ELAVL4 in AML patients with different survival status. Scatter plots of the five gene’s expression level in AML patients with different survival status based on GEO dataset. *p < 0.05, **p < 0.01, ***p < 0.001. Abbreviations: GEO, Gene Expression Omnibus.

Additional file 5: Figure S5. Kaplan-Meier survival curve according to the DLC1 expression level for 48 AML patients in our center. Kaplan-Meier plots was used to visualize the overall survival probability of 48 patients based on the expression of DLC1 at diagnosis in our center.

Additional file 6: Table S1. Clinical characteristics of 48 AML patients. Table S2. Basic information for the included GEO databases.

Purpose: Understanding the mechanism of brain functional alterations in rectal cancer (RC) patients is of great significance to improve the prognosis and quality of life of patients. Additionally, the influence of chemotherapy on brain function in RC patients is still unclear. In this study, we aimed to investigate the alterations of brain functional network dynamics in RC patients and explore the effects of chemotherapy on temporal dynamics of dynamic functional connectivity (DFC). Methods: The group...

Table S1: SIMS analytical results of detrital zircons. Table S2: LA–ICP–MS analytical results of detrital zircons

Additional file 1: Figure S1. Study design. Figure S2. Tumor response of patients in the dose-escalation and dose-expansion phase. Figure S3. Percentage change from baseline in target lesion tumour burden over time in patients with select tumors at the recommended dose (30 mg/kg q3w). Figure S4. Receiver operating characteristic curve analysis of pSmad2 level in tumor cells for ORR per RECIST v1.1. Table S1. Pharmacokinetic parameters following a single infusion. Table S2. Summary of treatment-related...