Lamivudine is a first-line medication used for human immunodeficiency virus (HIV) treatment. To date, the population pharmacokinetics of lamivudine in Chinese HIV-infected adults have not been assessed. This study aimed to develop a population pharmacokinetic model for oral lamivudine in Chinese HIV-infected adults and to determine the optimal lamivudine dosage regimens. A total of 1113 samples, from 828 Chinese HIV-infected patients treated with lamivudine 300 mg every 24 hours, were pooled from two open-label, prospective...

The current study aimed to explore the incidence of MPL mutations and the clinical and molecular characteristics of AML with MPL mutation. In total, 1509 patients with newly diagnosed AML were retrospectively analyzed between January 2017 and December 2020. MPL mutations were detected via next-generation sequencing. During the same period, we also enrolled 30 patients with other myeloid neoplasms (MNs) with MPL mutation, which included myelodysplastic syndrome (n = 15), myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) (n...

Regional studies have found significant agglomeration effects of education development on economic growth. Regional favouritism is potentially closely related to public investment in education, further impacting regional growth. This paper provides significant empirical evidence on the potential impact of favouritism on education development in the Chinese context. Using data for 282 Chinese cities from 1996 to 2016 with treatment for endogeneity (Lewbel two-stage least squares estimator), the results provide evidence that Chinese provincial political leaders...

The binary complexes of MCO3···HF/XF (M = Zn and Cd; X = F, Cl, Br and I) have been studied using ab initio calculations. The carbonyl O atom is inclined to engage in a stronger H-bond or X-bond, with interaction energy up to −17 kcal/mol. The CdCO3 complex brings out a stronger H-bond or X-bond than does the ZnCO3 analogue. The H-bond is stronger than the X-bond for X = F and Cl, while an...

Drug delivery and triggered release in tumor cells would realize the ultimate goal of precise cancer treatment. An APE1 triggered DNA nanoprism was designed, aiming at the applications of both drug delivery and precise triggered drug release in cancer cell. We demonstrate that the AP-Prism was successfully used as a vehicle based on the intracellular endogenous enzyme APE1 triggered for controlled drug delivery and triggered release. The box like DNA prism was self-assembled by annealing...

The number and quality of oocytes in the ovarian reserve are related to fertility and reproductive lifespan in mammals. Some transcription factors have been demonstrated to determine oogenesis. The insulinoma-associated 2 (Insm2) gene is a member of the Snail transcriptional repressor superfamily. Recent studies have demonstrated Insm2 plays an essential role for insulin secretion and glucose intolerance in mice, but the functions of Insm2 in reproduction remain elusive. Here, by examination of Insm2 knockout mice,...

Model averaging has a rich history dating from its use for combining forecasts from time-series models (Bates and Granger) and presents a compelling alternative to model selection methods. We propose a frequentist model averaging procedure defined over categorical regression splines (Ma, Racine, and Yang) that allows for mixed-data predictors, as well as nonnested and heteroscedastic candidate models. We demonstrate the asymptotic optimality of the proposed model averaging estimator, and develop a post-averaging inference theory for...

Bimetallic Pt/Ag nanoparticles (Pt/Ag NPs) were synthesized using 3-hydroxyphenyl-boronic acid as the reducing and stabilizing agent by a simple, one-step hydrothermal method. The bimetallic Pt/Ag NPs were demonstrated to possess intrinsic peroxidase mimetic catalytic activity for the luminol/H2O2 reaction to generate chemiluminescence (CL). The catalytic properties of the bimetallic Pt/Ag NPs were thoroughly investigated. The results showed that the combination of Pt and Ag greatly enhanced the chemiluminescence which is attributed to their synergy. Moreover,...

Bimetallic Pt/Ag nanoparticles (Pt/Ag NPs) were synthesized using 3-hydroxyphenyl-boronic acid as the reducing and stabilizing agent by a simple, one-step hydrothermal method. The bimetallic Pt/Ag NPs were demonstrated to possess intrinsic peroxidase mimetic catalytic activity for the luminol/H2O2 reaction to generate chemiluminescence (CL). The catalytic properties of the bimetallic Pt/Ag NPs were thoroughly investigated. The results showed that the combination of Pt and Ag greatly enhanced the chemiluminescence which is attributed to their synergy. Moreover,...

Soluble dietary fiber was extracted from spent Morchella importuna by optimizing the extraction conditions using the response surface method. Response surface analysis results indicated that the extraction yield of MI-SDF reached up to 15.38 ± 0.16% under the optimized conditions with optimal lye concentration of 2.9%, extraction temperature of 71°C and extraction time of 2 h. The results of scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction analyses suggested that M....

Soluble dietary fiber was extracted from spent Morchella importuna by optimizing the extraction conditions using the response surface method. Response surface analysis results indicated that the extraction yield of MI-SDF reached up to 15.38 ± 0.16% under the optimized conditions with optimal lye concentration of 2.9%, extraction temperature of 71°C and extraction time of 2 h. The results of scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction analyses suggested that M....

The problem of nonparametric estimation of a univariate density with rth continuous derivative on compact support is addressed (r≥2). If the density function has compact support and is non-zero at either boundary, regular kernel estimator will be completely biased at such boundary. Although several correction methods were proposed to improve the bias at the boundary to h2 in the last decades, this paper initiates a way to further improve bias to higher order (hr) for...

Natural attenuation is a major ecosystem function allowing to abate soil organic contaminants such as polycyclic aromatic hydrocarbons (PAHs). Biodegradation of PAHs is classically considered as the major driver of natural attenuation, yet the role of abiotic transformation, including photodegradation, chemical oxidation, formation of non-extractable residues, and polymerization, has been overlooked due to the lack of investigations until recently. This paper reviews PAHs dissipation in soils by abiotic processes such as photodegradation and oxidation catalyzed...

Acute acidic stress from sources such as acid rain might impact lake ecosystems in many aspects. Because zooplankton are sensitive to environmental change, they could be a good biotic indicator of acidification effects. We investigated survival and metabolic rates of 3 dominant zooplankton taxa in Lake Biwa, the cladoceran Daphnia pulicaria and the copepods Eodiaptomus japonicus and Cyclopoida spp., when subjected to different pH values (pH 4.0–8.0) at low (10 °C) and high (20 °C)...

Additional file 2. Predicted binding sites through JASPAR database, and the sequences of the constructed Luciferase activity reporter assays.

Additional file 2: Supplementary Table 1. Clinical features of 60 HNSCC patients. Supplementary Table 2. Oligonucleotide sequences used in this study. Supplementary Table 3. Antibodies used in this study. Supplementary Table 4. Primer sequences used for qRT-PCR in this study. Supplementary Table 5. Primers used for luciferase reporter in this study. Supplementary Table 6. Primers used for ChIP Assays in this study.

Additional file 1: Figure S1. Correlation between gene significance and related module membership. A. The correlation between gene significance and module membership in the gray module. B. The correlation between gene significance and module membership in the blue module. *p < 0.05, **p < 0.01, ***p < 0.001.

Additional file 5: Figure S5. Kaplan-Meier survival curve according to the DLC1 expression level for 48 AML patients in our center. Kaplan-Meier plots was used to visualize the overall survival probability of 48 patients based on the expression of DLC1 at diagnosis in our center.

Additional file 1: Table S1. PubMed search strategy. Table S2. Embase search strategy. Table S3. Cochrane library search strategy. Table S4. CNKI search strategy (in Chinese).

Additional file 1. Supplementary figures [81–83].

Additional file 2: Figure S1. Demarcation of patients using a SNN modularity optimization-based clustering algorithm. A Unsupervised clustering of NSCLC samples with four clusters. B Unsupervised clustering of LUAD and LUSC samples. C Distribution of LUAD and LUSC samples in four different clusters. Figure S2. Associations between NSCLC subtypes and TME features. A Levels of stromal score, immune score, ESTIMATE score, and tumor purity in LUAD (n = 512), LUSC (n = 430), and LASC...

Supplemental material, sj-pdf-1-imr-10.1177_03000605221132711 for New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report by Xin Li, Xu Wang and Zheng Guan in Journal of International Medical Research

Iris japonica Thunberg is one of the horticultural species belonging to the Iris genus and Iridaceae family. Previous studies have revealed its hepatoprotective activity and ornamental values. However, little genetic and genomic information about this species is available. Here, to decipher the chloroplast genome and reveal its evolutionary characteristics, we sequenced, de novo assembled, and comprehensively analyzed the chloroplast genome of I. japonica. The genome was 152,453 bp in length and displayed a circular structure...

Iris japonica Thunberg is one of the horticultural species belonging to the Iris genus and Iridaceae family. Previous studies have revealed its hepatoprotective activity and ornamental values. However, little genetic and genomic information about this species is available. Here, to decipher the chloroplast genome and reveal its evolutionary characteristics, we sequenced, de novo assembled, and comprehensively analyzed the chloroplast genome of I. japonica. The genome was 152,453 bp in length and displayed a circular structure...

Additional file 3: Table S2. Top 10 gene interaction pairs identified by JDINAC after adjusting for menopausal status.