Sorghum (Sorghum bicolor L.) is the fifth largest crop in the world and has potential health benefits, but vast quantities of sorghum roots are discarded after harvest. Based on the previous antiplatelet aggregation for this species, two new multi-substituted 3H-indole alkaloids sorghumine A (1) and sorghumine B (2), together with 14 known compounds (3–16), were found from the water extract of sorghum roots. Compounds 1–2 were identified by analyzing their spectroscopic data and physic and...

Three new feruloyl glucuronopyranosyl glycerols, 1-O-α-D-(2′-feruloyl) glucuronopyranosyl glycerol (1), 1-O-α-D-(3′-feruloyl) glucuronopyranosyl glycerol (2), and 1-O-α-D-(4′-feruloyl) glucuronopyranosyl glycerol (3) were isolated and purified from the capitulum of Eriocaulon buergerianum Koern. Their structures were identified by spectroscopic and chemical methods. Molecular docking study showed that 1 is a potential inhibitor of TGF-β1 receptor. Bioassay results revealed that 1 exhibited strong inhibitory activity against the TGF-β-induced expression of α-smooth muscle actin (α-SMA) and fibronectin in human hepatic stellate...

Two pairs of flavonoid enantiomers (1a/1b and 2a/2b) together with three known analogues (3–5) were isolated from the heartwood of Dalbergia odorifera T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data. Compound 2 features an unusual 2-methyl-3(2H)-furanone moiety forming the C-ring of flavonoid, and its putative biosynthetic pathway is also proposed. Compounds 3‒5 exhibited significant inhibition of nitric...

Background: Childhood sexual abuse (CSA) is one of the prevalent forms of trauma experienced during childhood and adolescence. Previous research underscores its associations with depression, anxiety, post-traumatic stress disorder (PTSD), and psychosis. Objective: This study examined symptom connections between depression, anxiety, PTSD, and psychosis while simultaneously investigating whether these connections differed by gender among CSA survivors. Methods: A large-scale, cross-sectional study among 96,218 college students was conducted in China. Participants’ CSA was measured by the...

Additional file 1: Table S1. Vegetation indices used in this study. Table S2. Vegetation index ranking of feature selection methods at flowering. Table S3. Vegetation index ranking of feature selection methods at early grain filling. Table S4. Vegetation index ranking of feature selection methods at mid grain filling. Table S5. Vegetation index ranking of feature selection methods at mid grain filling.

Single-cell RNA sequencing studies have suggested that total mRNA content correlates with tumor phenotypes. Technical and analytical challenges, however, have so far impeded at-scale pan-cancer examination of total mRNA content. Here we present a method to quantify tumor-specific total mRNA expression (TmS) from bulk sequencing data, taking into account tumor transcript proportion, purity and ploidy, which are estimated through transcriptomic/genomic deconvolution. We estimate and validate TmS in 6,590 patient tumors across 15 cancer types, identifying...

Additional file 3: Table S1. The MeSH terms and the related entry terms.

Additional file 3: Table S1. The MeSH terms and the related entry terms.

Additional file 5: Table S3. Estimates of effects and quality ratings for comparison of regimens of neoadjuvant chemotherapy for locally advanced gastric cancer.

Additional file 6: Table S4. The stratified analysis of OS, DFS and R0 resectability according to treatment duration.

Additional file 1: Supplemental Figure 1. fMRI task paradigm. Supplemental Figure 2. Group difference in the Semantic Fluency-Fixation contrasts and its behavioral significance. One-way ANOVA, cluster-level P < 0.05, FWE corrected. Supplemental Table 1. The Post-hoc comparisons of the clinical characteristics in the China RSF multi-center cohort (Bonferroni corrected). Supplemental Table 2. Clinical characteristics of NC and AD patients in the Pitt center cohort. Supplemental Table 3. Correlation between PSD and cognition. Supplemental Table 4....

Additional file 2: Table S2. GSEA result.

Additional file 1: TableS1. Summary of sequencing data quality. Table S2. Gene composition in the plastomes of twelve plum cultivars. Table S3. Length of introns and exons inthe plastomes of twelve plumcultivars. Table S4. Statistics on simple sequencerepeats (SSRs) in the twelve plastomes. TableS5. The list of accession numbers of the plastome sequences used in thephylogenetic analyses of the Prunus. FigureS1. Genome map of P. salicina ‘Wanshuang plum’ plastome. Figure S2. Genome map of P....

Additional file 1: TableS1. Summary of sequencing data quality. Table S2. Gene composition in the plastomes of twelve plum cultivars. Table S3. Length of introns and exons inthe plastomes of twelve plumcultivars. Table S4. Statistics on simple sequencerepeats (SSRs) in the twelve plastomes. TableS5. The list of accession numbers of the plastome sequences used in thephylogenetic analyses of the Prunus. FigureS1. Genome map of P. salicina ‘Wanshuang plum’ plastome. Figure S2. Genome map of P....

Additional file 2. Raw data of this paper

Figure 3. Late Ordovician time scale, stages and graptolite, conodont and chitinozoan zonal schemes. The leftmost column is the chronometric time scale from Goldman et al. (2020, in Gradstein et al. 2020). Zonations and correlations for graptolites are modified from the following (and references therein) — Goldman et al. (2020), Loydell (2012), Maletz (2021), Maletz and Ahlberg (2018), VandenBerg and Cooper (1992), Cooper and Sadler (2012), Goldman et al. (2007a), and Zalasiewicz et al. (2009);...

Adherence to the use of child restraint system (CRS) can greatly reduce child casualties in road traffic accidents. This study aims to develop the behavior maintenance model of CRS use based on the health action process approach (HAPA) theory to explore the maintenance mechanisms, suggesting appropriate intervention strategies. Adopting the multi-stage stratified cluster random sampling method, a cross-sectional survey for guardians recruited from kindergarten and primary school was conducted using the questionnaire developed based on...

Supplemental material for integrated analysis of the genomic and transcriptional profile of gliomas with isocitrate dehydrogenase-1 and tumor protein 53 mutations by Han-Qing Liu, Wei-Xin Li, Ya-Wen An, Tao Wu, Guang-Yu Jiang, Yu Dong, Wei-Xin Chen, Jian-Chun Wang, Cheng Wang, and Shuo Song in the International Journal of Immunopathology and Pharmacology.

Supplemental material, sj-docx-1-cre-10.1177_02692155221135729 for Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials by Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang and Huachun Zhang in Clinical Rehabilitation

Supplemental material, sj-docx-2-cre-10.1177_02692155221135729 for Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials by Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang and Huachun Zhang in Clinical Rehabilitation

Supplemental material, sj-docx-5-cre-10.1177_02692155221135729 for Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials by Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang and Huachun Zhang in Clinical Rehabilitation

Additional file 1. Supplementary tables and figures.

Additional file 1. CARE-checklist.

Additional file 7: Supplementary file1. Preparation for iTRAQ quantitative proteomics study, related to additional file 1

Additional file 13: Table S8. Spearman correlation coefficients (r) between ASVs and testicular genes in the FMT experiment.