53 Works

Nalbuphine: a candidate for treatment of women overwhelmed with sudden, intense labor pain?

Seraina Schoppmann, Deborah Spiess, Daniel Müller, Andrea Burch, Roland Zimmermann & Ana Paula Simões-Wüst
On very rare occasions, women are overwhelmed with sudden, intense labor pain in the context of ultra-rapid late second stage of labor, especially when the head is crowning. The consequences may comprise serious pelvic floor damage for the mother and hypoxia for the fetus. Drugs like nalbuphine for immediate maternal analgesia and sedation would be helpful. This mixed opioid agonist–antagonist, that was used in obstetric anesthesia in the 1980s, acts quickly while side effects for...

Additional file 1 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 1: Fig. S1. Components of variation in the whole methylome dataset. a) Scree plot representing the percentage of explained variability by the first five principal components of PCA performed on the whole dataset (n=731,635 CpG sites, n=255 samples). b) Singular value decomposition (SVD) plot assessing the correlation between the first five significant components of variation in the dataset and other biological factors of interest (Hypertension type –PHT, CS, PA, PPGL-, age, sex, cell...

Additional file 1 of Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Additional file 1. Chronic health conditions

Hybrid Kronecker Product Decomposition and Approximation

Chencheng Cai, Rong Chen & Han Xiao
Discovering underlying low dimensional structure of a high-dimensional matrix is traditionally done through low rank matrix approximations in the form of a sum of rank-one matrices. In this article, we propose a new approach. We assume a high-dimensional matrix can be approximated by a sum of a small number of Kronecker products of matrices with potentially different configurations, named as a hybrid Kronecker outer Product Approximation (hKoPA). It provides an extremely flexible way of dimension...

Hybrid Kronecker Product Decomposition and Approximation

Chencheng Cai, Rong Chen & Han Xiao
Discovering underlying low dimensional structure of a high-dimensional matrix is traditionally done through low rank matrix approximations in the form of a sum of rank-one matrices. In this article, we propose a new approach. We assume a high-dimensional matrix can be approximated by a sum of a small number of Kronecker products of matrices with potentially different configurations, named as a hybrid Kronecker outer Product Approximation (hKoPA). It provides an extremely flexible way of dimension...

Additional file 1 of Hand hygiene improvement of individual healthcare workers: results of the multicentre PROHIBIT study

Tjallie van der Kooi, Hugo Sax, Hajo Grundmann, Didier Pittet, Sabine de Greeff, Jaap van Dissel, Lauren Clack, Albert W. Wu, Judith Davitt, Sofia Kostourou, Alison Maguinness, Anna Michalik, Viorica Nedelcu, Márta Patyi, Janja Perme Hajdinjak, Milena Prosen, David Tellez, Éva Varga, Fani Veini, Mirosław Ziętkiewicz & Walter Zingg
Additional file 1: Table S1. Association between hand hygiene and activity index during baseline and intervention; Table S2. Overall (i.e. for all HCWs) hand hygiene compliance per hospital, during baseline and the intervention period; Figure S1. Boxplot (median, quartiles and ranges) of individual HH compliance both during baseline and intervention period; Figure S2. Boxplot (median, quartiles and ranges) of hand hygiene increase (in percentage points) in the group of improving HCWs; Figure S3. Variability within...

Additional file 1 of VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial

Philipp Reinhardt, Roland Giger, Eberhard Seifert, Mohamed Shelan, Elena Riggenbach, Dario Terribilini, Andreas Joosten, Daniel H. Schanne, Daniel M. Aebersold, Peter Manser, Matthias S. Dettmer, Christian Simon, Esat M. Ozsahin, Raphaël Moeckli, Andreas Limacher, Francesca Caparrotti, Deepa Nair, Jean Bourhis, Martina A. Broglie, Abrahim Al-Mamgani & Olgun Elicin
Additional file 1. Full study protocol

Additional file 3 of Practice of oxygen use in anesthesiology – a survey of the European Society of Anaesthesiology and Intensive Care

Martin Scharffenberg, Thomas Weiss, Jakob Wittenstein, Katharina Krenn, Magdalena Fleming, Peter Biro, Stefan De Hert, Jan F. A. Hendrickx, Daniela Ionescu & Marcelo Gama de Abreu
Additional file 3: Supplementary Table 2. Post-surgical oxygen management by geographical regions.

Additional file 1 of Microcirculatory alterations in critically ill COVID-19 patients analyzed using artificial intelligence

Matthias Peter Hilty, Emanuele Favaron, Pedro David Wendel Garcia, Yavuz Ahiska, Zuhre Uz, Sakir Akin, Moritz Flick, Sesmu Arbous, Daniel A. Hofmaenner, Bernd Saugel, Henrik Endeman, Reto Andreas Schuepbach & Can Ince
Additional file 1. Supplementary information.

Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

Iker Valle Aramburu, Dennis Hoving, Spyros I Vernardis, Martha CF Tin, Marianna Ioannou, Mia I Temkin, Nathalia M De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T Chiesa, John E Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser & Venizelos Papayannopoulos
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation of DNase I or the actin scavenger gelsolin. Splenocyte death and neutrophil extracellular trap (NET) clearance deficiencies were prevalent in individuals with severe COVID-19...

Additional file 1 of Hand hygiene improvement of individual healthcare workers: results of the multicentre PROHIBIT study

Tjallie van der Kooi, Hugo Sax, Hajo Grundmann, Didier Pittet, Sabine de Greeff, Jaap van Dissel, Lauren Clack, Albert W. Wu, Judith Davitt, Sofia Kostourou, Alison Maguinness, Anna Michalik, Viorica Nedelcu, Márta Patyi, Janja Perme Hajdinjak, Milena Prosen, David Tellez, Éva Varga, Fani Veini, Mirosław Ziętkiewicz & Walter Zingg
Additional file 1: Table S1. Association between hand hygiene and activity index during baseline and intervention; Table S2. Overall (i.e. for all HCWs) hand hygiene compliance per hospital, during baseline and the intervention period; Figure S1. Boxplot (median, quartiles and ranges) of individual HH compliance both during baseline and intervention period; Figure S2. Boxplot (median, quartiles and ranges) of hand hygiene increase (in percentage points) in the group of improving HCWs; Figure S3. Variability within...

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Additional file 1 of Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Additional file 1. Chronic health conditions

Additional file 1 of Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis, Alistair Nichol, Andreas Lundin, Jacob Hollenberg, Naomi Hammond, Manoj Saxena, Annborn Martin, Miroslav Solar, Fabio Silvio Taccone, Josef Dankiewicz … & Paolo Pelosi
Additional file 1: Additional statistical analysis of subgroups population and association with outcome.

Additional file 1 of VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial

Philipp Reinhardt, Roland Giger, Eberhard Seifert, Mohamed Shelan, Elena Riggenbach, Dario Terribilini, Andreas Joosten, Daniel H. Schanne, Daniel M. Aebersold, Peter Manser, Matthias S. Dettmer, Christian Simon, Esat M. Ozsahin, Raphaël Moeckli, Andreas Limacher, Francesca Caparrotti, Deepa Nair, Jean Bourhis, Martina A. Broglie, Abrahim Al-Mamgani & Olgun Elicin
Additional file 1. Full study protocol

Additional file 4 of Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Manja Deforth, Caroline E. Gebhard, Susan Bengs, Philipp K. Buehler, Reto A. Schuepbach, Annelies S. Zinkernagel, Silvio D. Brugger, Claudio T. Acevedo, Dimitri Patriki, Benedikt Wiggli, Raphael Twerenbold, Gabriela M. Kuster, Hans Pargger, Joerg C. Schefold, Thibaud Spinetti, Pedro D. Wendel-Garcia, Daniel A. Hofmaenner, Bianca Gysi, Martin Siegemund, Georg Heinze, Vera Regitz-Zagrosek, Catherine Gebhard & Ulrike Held
Additional file 4. Logistic regression model based on the ABE and ABESS variable selection, calculated on the total cohort.

sj-docx-1-eso-10.1177_23969873221145391 – Supplemental material for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke

Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P Westphal, Valerie Schütz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kägi, Joan Montaner, Alejandro Bustamante, Elena Palà, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja Saleh, Arnold von Eckardstein … & Mira Katan
Supplemental material, sj-docx-1-eso-10.1177_23969873221145391 for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke by Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P Westphal, Valerie Schütz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kägi, Joan Montaner, Alejandro Bustamante, Elena Palà, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja...

sj-docx-1-eso-10.1177_23969873221145391 – Supplemental material for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke

Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P Westphal, Valerie Schütz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kägi, Joan Montaner, Alejandro Bustamante, Elena Palà, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja Saleh, Arnold von Eckardstein … & Mira Katan
Supplemental material, sj-docx-1-eso-10.1177_23969873221145391 for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke by Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P Westphal, Valerie Schütz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kägi, Joan Montaner, Alejandro Bustamante, Elena Palà, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja...

The Dimensions of Consciousness: From perceptual illusions to psychedelics. An interview of Olivia Carter by Katrin H. Preller.

Olivia Carter & Katrin, H. Preller
In this interview, the psychologist and neuroscientist Olivia Carter (University of Melbourne, Australia) explains how she became interested in the field of consciousness. We discuss how her work on visual perception has led her to study the effect of psychedelics and how this has inspired a multidimensional model of consciousness. We discuss the potential contents of “higher” states of consciousness and argue that the existence of those is an unresolved question. We finish the exchange...

Nalbuphine: a candidate for treatment of women overwhelmed with sudden, intense labor pain?

Seraina Schoppmann, Deborah Spiess, Daniel Müller, Andrea Burch, Roland Zimmermann & Ana Paula Simões-Wüst
On very rare occasions, women are overwhelmed with sudden, intense labor pain in the context of ultra-rapid late second stage of labor, especially when the head is crowning. The consequences may comprise serious pelvic floor damage for the mother and hypoxia for the fetus. Drugs like nalbuphine for immediate maternal analgesia and sedation would be helpful. This mixed opioid agonist–antagonist, that was used in obstetric anesthesia in the 1980s, acts quickly while side effects for...

The 2022 World Health Organization classification of tumours of the urinary system and male genital organs-Part A: Renal, penile, and testicular tumours.

Holger Moch, Mahul B Amin, Daniel M Berney, Eva M Compérat, Anthony J Gill, Arndt Hartmann, Santosh Menon, Maria R Raspollini, Mark A Rubin, John R Srigley, Puay Hoon Tan, Satish K Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree & George J Netto
The fifth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "Blue Book"), published in 2022, contains significant revisions. This review summarises the most relevant changes for renal, penile, and testicular tumours. In keeping with other volumes in the fifth edition series, the WHO classification of urogenital tumours follows a hierarchical classification and lists tumours by site, category, family, and type. The section "essential and desirable diagnostic criteria" included in the WHO...

The 2022 World Health Organization classification of tumours of the urinary system and male genital organs-Part A: Renal, penile, and testicular tumours.

Holger Moch, Mahul B Amin, Daniel M Berney, Eva M Compérat, Anthony J Gill, Arndt Hartmann, Santosh Menon, Maria R Raspollini, Mark A Rubin, John R Srigley, Puay Hoon Tan, Satish K Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree & George J Netto
The fifth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "Blue Book"), published in 2022, contains significant revisions. This review summarises the most relevant changes for renal, penile, and testicular tumours. In keeping with other volumes in the fifth edition series, the WHO classification of urogenital tumours follows a hierarchical classification and lists tumours by site, category, family, and type. The section "essential and desirable diagnostic criteria" included in the WHO...

Additional file 1 of Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis, Alistair Nichol, Andreas Lundin, Jacob Hollenberg, Naomi Hammond, Manoj Saxena, Annborn Martin, Miroslav Solar, Fabio Silvio Taccone, Josef Dankiewicz … & Paolo Pelosi
Additional file 1: Additional statistical analysis of subgroups population and association with outcome.

Additional file 2 of VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial

Philipp Reinhardt, Roland Giger, Eberhard Seifert, Mohamed Shelan, Elena Riggenbach, Dario Terribilini, Andreas Joosten, Daniel H. Schanne, Daniel M. Aebersold, Peter Manser, Matthias S. Dettmer, Christian Simon, Esat M. Ozsahin, Raphaël Moeckli, Andreas Limacher, Francesca Caparrotti, Deepa Nair, Jean Bourhis, Martina A. Broglie, Abrahim Al-Mamgani & Olgun Elicin
Additional file 2. SPIRIT checklist

Additional file 3 of Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Additional file 3. Search strategies

Registration Year

  • 2022
    50
  • 2021
    2
  • 2020
    1

Resource Types

  • Text
    53

Affiliations

  • University Hospital of Zurich
    53
  • Charité - University Medicine Berlin
    14
  • University Hospital of Bern
    11
  • Hospital Universitario Ramón y Cajal
    11
  • Hospital Universitario Fundación Alcorcón
    8
  • Instituto Ramón y Cajal de Investigación Sanitaria
    8
  • Francisco de Vitoria University
    8
  • University of Maryland, Baltimore
    8
  • University of Zurich
    7
  • University Hospital of Basel
    7