simulation results

FLASH (ultra-high dose rate) radiotherapy spares normal tissue while keeping tumor control. However, the mechanism of the FLASH effect remains unclear and may have consequences beyond the irradiated area. We reanalyze the available results of ultra-high-dose-rate-related experiments to find out the key points of the mechanism of the FLASH effect. Then, we present a hypothesis on the mechanism of the FLASH effect: FLASH beams generate a high transient concentration of peroxyl radicals leading to a...

Two new cyclotrypyamine alkaloids equisetinines A and B, as well as three known alkaloids (3–5) were isolated from the stems of Ephedra equisetina Bunge. Their structures were characterized by spectroscopic methods, and the absolute configurations of the new compounds were determined by interpretation of their electronic circular dichroism. Anti-asthmatic activities of compounds were evaluated by releasing β-Hex in C48/80-induced RBL-2H3 cells, and compound 5 exhibited significant anti-asthmatic activities.

Arsenic and cadmium pose a potential health risk to human beings via rice grain consumption. In the current study, a pot experiment was conducted to evaluate the effect of Br (5 mM and 20 mM) and Se (1 mM) at rice tillering and filling stages on Cd and As accumulation in rice grain and their health risk indices. The results showed that Br or Se applications at different stages of rice improved the photosynthesis, reduce...

Arsenic and cadmium pose a potential health risk to human beings via rice grain consumption. In the current study, a pot experiment was conducted to evaluate the effect of Br (5 mM and 20 mM) and Se (1 mM) at rice tillering and filling stages on Cd and As accumulation in rice grain and their health risk indices. The results showed that Br or Se applications at different stages of rice improved the photosynthesis, reduce...

Supplemental material, sj-docx-1-sgo-10.1177_21582440221141299 for Correlation Monitoring Method and model of Science-Technology-Industry in the AI Field: A Case of the Neural Network by Xiaoli Wang, Yun Liu, Lingdi Chen and Yifan Zhang in SAGE Open

Additional file 4: Table S1. Synthetic lethal interactive pairs and chemical inhibitors involving SWI/SNF members.

Additional file 1: Table S1. List of all the participants. Table S2. The association between health behaviors and mental health among college students. Table S3. Mental health scores stratified by depression, anxiety symptoms. Table S4. The mediation effect of coping style on the relationship between lifestyle health behaviors and mental health symptoms in college students. Table S5. Model characteristics for the conditional process analysis. Table S6. Bootstrapped conditional direct and indirect effects. Fig. S1. The...

Revised Supplementary Document

Additional file 1: Figure S1. (A) Representative images of dissected tumors across the different treatment groups. (B-C) PCNA protein expression levels were selected as indices of tumor tissue proliferation for immunohistochemical detection and analysis. (D-E) TUNEL experiment of tumor tissues in different treatment groups. Figure S2. Hematoxylin and eosin staining tests (Figure S2A) and serum biochemical indices, including albumin, alanine aminotransferase, creatinine, and urea levels,(Figure S2B-E) showed that there was no significant histological evidence of...

Additional file 1. The tables of the filtering parameters setting using Prinseq-lite software, primers and probes used to detect co-infection respiratory viruses, type analysis of common virus-related sequence viral in MP positive and MP negative (TTV has been removed). Table S1: The filtering parameters setting using Prinseq-lite software. Table S2: Primers and probes used to detect co-infection respiratory viruses. Table S3: Type analysis of common virus-related sequence viral in MP positive and MP negative (TTV...

The risk factors for stroke in elderly patients with chronic kidney disease (CKD) are not well understood. This study aimed to explore the influence of systolic blood pressure (SBP) on the risk of stroke in a large cohort of elderly patients with stage 3–5 CKD. We retrospectively identified 665 patients hospitalized in Beijing Friendship Hospital from January 2000 to December 2021. Patients were followed up until the occurrence of stroke or death. Multivariate logistic regression...

Additional file 2: Table S2. Primer sequences for quantitative real-time PCR and real-time PCR analyses.

A wave of Omicron infections rapidly emerged in China in 2022, but large-scale data concerning the safety profile of vaccines and Coronavirus disease 2019 (COVID-19) infection features in liver transplant (LT) recipients have not been collected. Therefore, the aim of this study was to assess the protectiveness and safety profile of the inactivated vaccines in LT patients against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections. A multi-centre retrospective study was conducted in...

As part of an ongoing project on Rehmannia species, three new pyridine alkaloides (glutinosines A − C), and one new iridoid analogue (rehmaglutin E), were isolated from the leaves of Rehmannia glutinosa. The structures of the new compounds were established by extensive spectroscopic analysis and electronic circular dichroism calculations.

Supplementary Material 1. Supplemental Methods. 1) Demographic characteristics. 2) Health status. 3) Child characteristics. 4) Socioeconomic level. Supplementary tables. Table S1. The questionnaire items of CESD-10 and its answer options and marks assigned. Table S2. Baseline characteristics between participants included and not included. Table S3 Sensitivity analysis of the association between living arrangements and cognitive decline. Table S4 Sensitivity analysis of gender differences in the association between living arrangements and cognitive decline.

Based on the inhibition of mitochondrial permeability transition pore (mPTP) opening, puerarin (PUE) has a good potential to reduce myocardial ischemia/reperfusion injury (MI/RI). However, the lack of targeting of free PUE makes it difficult to reach the mitochondria. In this paper, we constructed matrix metalloproteinase-targeting peptide (MMP-TP) and triphenylphosphonium (TPP) cation co-modified liposomes loaded with PUE (PUE@T/M-L) for mitochondria-targeted drug delivery. PUE@T/M-L had a favorable particle size of 144.9 ± 0.8 nm, an encapsulation efficiency...

Supplemental material, sj-docx-1-jbm-10.1177_03936155231166721 for Alterations of commensal microbiota are associated with pancreatic cancer by Tian Chen, Xuejiao Li, Gaoming Li, Yun Liu, Xiaochun Huang, Wei Ma, Chao Qian, Jie Guo, Shuo Wang, Qin Qin and Shanrong Liu in The International Journal of Biological Markers

Robinia pseudoacacia flower is a natural product with many biological activities, including antioxidation. To further develop its antioxidation, the extract was fermented by Aspergillus niger FFCC 3112 in the medium with carbon to nitrogen ratio of 1.4:1 and initial pH of 4.2 for 3.5 days to form the best antioxidant activity of the fermentation product by strain screening, single factor optimization, and response surface methodology. Further analysis, isolation and activity determination showed that a main...

Supplemental Document

Supplemental Document, no-red-lined version

Additional file 1. Additional tables S1–S5 and additional figures S1–S5.

Additional file 1: Text S1. Supplementary description of methods.

Additional file 1: Supplementary figures S1–S5 and supplementary materials and methods.

Additional file 1: Table S1. Summary of clinical characteristics for patients included in this study. Figure S1. Prognostic role of circulating immune cells in pre-treatment samples. a–d Kaplan–Meier curves for OS showing the association between relative abundance of B cell memory (a), B cell naive (b), NK cell activated (c), T cells follicular helper (d) and OS (log-rank test, p < 0.05). Figure S2. Identification of DEGs among samples with different responses at different post-treatment...