122 Works

Neuronal mitochondria-targeted therapy for Alzheimer’s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems

Yang Han, Xiaoyang Chu, Lin Cui, Shiyao Fu, Chunsheng Gao, Yi Li & Baoshan Sun
Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer’s disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targeted therapy. However, the efficient intravenous delivery of therapeutic agents to neuronal mitochondria in the brain remains a major challenge due to the complicated physiological environment. Recently, biomaterials-based nanomedicine has been widely...

Taberdines L and M, two new alkaloids from Tabernaemontana divaricata

Lingling Han, Kepu Huang, Chen Chen, Wentao Zhu, Yehan Ma, Xiaojiang Hao, Hongping He & Yu Zhang
Two new alkaloids, taberdines L (1) and M (2), together with six known alkaloids, were isolated from the twigs and leaves of Tabernaemontana divaricata. Taberdine L (1) represents the first optically active natural member of the allo iboga class of alkaloids with the ethyl side chain in a bridgehead position. Their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation. The in vitro cytotoxic activities of 1 and 2...

Comparison of DNA methylation measurements from EPIC BeadChip and SeqCap targeted bisulphite sequencing in PON1 and nine additional candidate genes

Dennis Khodasevich, Anna R. Smith, Karen Huen, Brenda Eskenazi, Andres Cardenas & Nina Holland
Epigenome-wide association studies (EWAS) are widely implemented in epidemiology, and the Illumina HumanMethylationEPIC BeadChip (EPIC) DNA microarray is the most-used technology. Recently, next-generation sequencing (NGS)-based methods, which assess DNA methylation at single-base resolution, have become more affordable and technically feasible. While the content of microarray technology is fixed, NGS-based approaches, such as the Roche Nimblegen, SeqCap Epi Enrichment System (SeqCap), offer the flexibility of targeting most CpGs in a gene. With the current usage of...

The 1791 and 1795 Slave Conspiracies in Pointe Coupée, Louisiana: A Geospatial Dataset

Patricia Frontiera, Susan Powell, Shadrick Small, Jenelle Thomas & Bryan Wagner

Additional file 1 of Pandemic-related socioeconomic disruptions and adverse health outcomes: a cross-sectional study of female caregivers

Erika M. Brown, Lia C.H. Fernald, Rita Hamad, Mekhala Hoskote, Kaitlyn E. Jackson & Wendi Gosliner
Supplementary Material 1

Additional file 1 of Mediation analysis of erythrocyte lipophilic index on the association between BMI and risk of oral cancer

Yi Fan, Qing Chen, Yaping Wang, Jing Wang, Yanni Li, Sijie Wang, Yanfeng Weng, Qiujiao Yang, Chen Chen, Lisong Lin, Yu Qiu, Fa Chen, Baochang He & Fengqiong Liu
Additional file 1: Supplement Figure 1. Association between the lipophilic index and oral cancer by stratified analysis.

Additional file 1 of Early child stimulation, linear growth and neurodevelopment in low birth weight infants

Ravi Prakash Upadhyay, Sunita Taneja, Tor A. Strand, Halvor Sommerfelt, Mari Hysing, Sarmila Mazumder, Nita Bhandari, Jose Martines, Tarun Dua, Patricia Kariger & Rajiv Bahl
Additional file 1: Supplementary Table 1. Comparison of baseline characteristics of the infants with neurodevelopment data at 12 months (N = 516) and those that did not have (N = 36).

Additional file 4 of The extrachromosomal circular DNAs of the rice blast pathogen Magnaporthe oryzae contain a wide variety of LTR retrotransposons, genes, and effectors

Pierre M. Joubert & Ksenia V. Krasileva
Additional file 4: Table S1. Number of eccDNA forming regions called using whole genome sequencing data. Table S2. Summary of protocols used to extract eccDNAs in studies analyzed in this manuscript. Table S3. Primers used for qPCR validation of linear DNA degradation and outward PCR validation of eccDNA forming regions.

An upstream-downstream externality related to water quality: The case of the Porong River in Indonesia

Frank Jensen, Venticia Hukom, Rasmus Nielsen & Max Nielsen
In this paper, we discuss an upstream-downstream externality related to water quality (the level of ammonia) in a river by distinguishing between a non-cooperative and cooperative case. As empirical case, we use the Porong River, which is located in the East Java province of Indonesia. In this river, aquaculture farmers are located downstream while the industrial firms are placed upstream. In both the non-cooperative and cooperative case, we find that the optimal profit by a...

Additional file 3 of MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao
Additional file 2. Supplementary Table.

Additional file 1 of A booster hepatitis B vaccine for children with maternal HBsAg positivity before 2 years of age could effectively prevent vaccine breakthrough infections

Yarong Song, Xin Zhang, Minmin Liu, Xiangjun Zhai, Jianxun Liu, Yi Li, Lili Li, Yiwei Xiao, Zhongping Duan, Jing Jiang, Feng Ding, Liguo Zhu, Jie Jiang, Huaibin Zou, Hui Zhuang, Jie Wang & Jie Li
Additional file 1: Fig. S1. Enrolment and follow-up of participants. Table S1. Comparison of the baseline characteristics of children followed up and lost to follow-up and those of their mothers. Table S2. Comparison of baseline characteristics of children with different anti-HBs levels at the age of 7 months and those of their mothers. Table S3. Genotype, subtype, homology and S region mutation comparisons of infected mother-child HBV pairs. Table S4. Comparison of the baseline characteristics...

Additional file 2 of MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao
Additional file 1. Supplementary Figure.

Supplementary document for High brightness and broad modulation bandwidth InGaN-based red micro-LEDs integrated with plasmonic gratings - 6087766.pdf

Guogang Zhang, Lijun Zhang, Fang-Fang REN, Yi Li & yongjin wang
supplemental-document

Additional file 1 of The reach of fertility decline: a longitudinal analysis of human capital gains across generations

Stephanie M. Koning, Alberto Palloni, Jenna Nobles, Ian Coxhead & Lia C. H. Fernald
Additional file 1: Supplementary Tables and Figures.

Additional file 2 of The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry

Hiba Mohammed Taha, Reza Aalizadeh, Nikiforos Alygizakis, Jean-Philippe Antignac, Hans Peter H. Arp, Richard Bade, Nancy Baker, Lidia Belova, Lubertus Bijlsma, Evan E. Bolton, Werner Brack, Alberto Celma, Wen-Ling Chen, Tiejun Cheng, Parviel Chirsir, Ľuboš Čirka, Lisa A. D’Agostino, Yannick Djoumbou Feunang, Valeria Dulio, Stellan Fischer, Pablo Gago-Ferrero, Aikaterini Galani, Birgit Geueke, Natalia Głowacka, Juliane Glüge … & Emma L. Schymanski
Additional file 2: Overview of the NORMAN-SLE website (DOCX format) as of 30 May 2022 [82].

Additional file 2 of The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry

Hiba Mohammed Taha, Reza Aalizadeh, Nikiforos Alygizakis, Jean-Philippe Antignac, Hans Peter H. Arp, Richard Bade, Nancy Baker, Lidia Belova, Lubertus Bijlsma, Evan E. Bolton, Werner Brack, Alberto Celma, Wen-Ling Chen, Tiejun Cheng, Parviel Chirsir, Ľuboš Čirka, Lisa A. D’Agostino, Yannick Djoumbou Feunang, Valeria Dulio, Stellan Fischer, Pablo Gago-Ferrero, Aikaterini Galani, Birgit Geueke, Natalia Głowacka, Juliane Glüge … & Emma L. Schymanski
Additional file 2: Overview of the NORMAN-SLE website (DOCX format) as of 30 May 2022 [82].

Additional file 1 of Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma

Jingting Wang, Nan Wang, Zeyu Zheng, Yanlu Che, Masanobu Suzuki, Satoshi Kano, Jianguang Lu, Peng Wang, Yanan Sun & Akihiro Homma
Additional file 1.

Additional file 1 of Supraglottic jet oxygenation and ventilation decreased hypoxemia during gastrointestinal endoscopy under deep sedation at high altitudes: a randomized clinical trial

Bailin Jiang, Yi Li, Deji Ciren, Ouzhu Dawa, Yi Feng & Ciren Laba
Additional file 1: Supplementary Table 1. Adjusted and sensitivity analyses.

Fiscal Policy in the Age of COVID-19: Does It “Get in All of the Cracks”?

Pierre-Olivier Gourinchas, Şebnem Kalemli-Özcan, Veronika Penciakova & Nicholas Sander
The COVID-19 pandemic caused an uncommon recession that required uniquely large and often novel fiscal responses. Government-imposed lockdowns created severe supply bottlenecks in some sectors of the economy, and physical distancing led to dramatic changes in patterns of consumer spending. Some sectors of the economy—such as online retail—benefited, while many others—such as restaurants and travel—struggled to deal with losses of customers and the constraints of lockdowns and remote work. In reaction to this, many governments...

Additional file 2 of Comparison of different concentrations of a povidone iodine-diluted sitz bath in the prevention of perianal infection in patients undergoing chemotherapy for hematological malignancy: study protocol for a randomized controlled trial

Yuqin Luo, Yingli Wang, Mei Yang, Ting Luo, Fengjiao Chen, Yamei Leng, Li Zhou, Jinbo Fang, Yuan Li & Chen Chen
Additional file 2. SAP.

Additional file 3 of Comparison of different concentrations of a povidone iodine-diluted sitz bath in the prevention of perianal infection in patients undergoing chemotherapy for hematological malignancy: study protocol for a randomized controlled trial

Yuqin Luo, Yingli Wang, Mei Yang, Ting Luo, Fengjiao Chen, Yamei Leng, Li Zhou, Jinbo Fang, Yuan Li & Chen Chen
Additional file 3. Informed consent materials.

Additional file 1 of Probabilistic linguistic fuzzy cognitive maps: applications to the critical factors affecting the health of rural older adults

Jian Wu, Yucheng Chen, Zengwen Wang, Guoheng Hu & Chen Chen
Additional file 1. Supplementary.

Supplementary document for Anomalous π Modes by Floquet Engineering in Optical Lattices with Long-range Coupling - 6137074.pdf

Shengjie Wu, Wange Song, Zhiyuan Lin, Chen Chen, Shining Zhu & Tao Li
Detailed theoretical calculation and experimental proposal

Additional file 1 of Application of online teaching mode combining case studies and the MOOC platform in obstetrics and gynecology probation teaching

Yi Li, Chunfen Yang, Wenyan Liao, Shuangjian Yang, Wenjuan Tong, Li Li, Hui Lan & Dong Yang
Additional file 1.

Additional file 1 of Economic evaluation of implementation science outcomes in low- and middle-income countries: a scoping review

Akash Malhotra, Ryan R. Thompson, Faith Kagoya, Felix Masiye, Peter Mbewe, Mosepele Mosepele, Jane Phiri, Jairos Sambo, Abigail Barker, Drew B. Cameron, Victor G. Davila-Roman, William Effah, Brian Hutchinson, Michael Laxy, Brad Newsome, David Watkins, Hojoon Sohn & David W. Dowdy
Additional file 1. Protocol for scoping review.

Registration Year

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Affiliations

  • University of California, Berkeley
    122
  • Tongji University
    65
  • Peking University
    64
  • Shanghai Jiao Tong University
    52
  • Sun Yat-sen University
    50
  • West China Hospital of Sichuan University
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  • Anhui Medical University
    45
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    42
  • Huazhong University of Science and Technology
    41
  • Sichuan University
    41