Cognitive behavioral treatment (CBT) and selective serotonin reuptake inhibitors (SSRIs) are considered first-line treatments for childhood anxiety disorders (ADs). The objective of this current analysis was to conduct a network meta-analysis to evaluate the comparative effectiveness of CBT, pharmacotherapy, and the combination of the two in treating pediatric ADs. The studies included consisted of randomized controlled trials evaluating non-selective serotonin reuptake inhibitors (e.g. clomipramine), SSRIs, selective noradrenaline reuptake inhibitors, CBT, or a combination of CBT...

Cognitive behavioral treatment (CBT) and selective serotonin reuptake inhibitors (SSRIs) are considered first-line treatments for childhood anxiety disorders (ADs). The objective of this current analysis was to conduct a network meta-analysis to evaluate the comparative effectiveness of CBT, pharmacotherapy, and the combination of the two in treating pediatric ADs. The studies included consisted of randomized controlled trials evaluating non-selective serotonin reuptake inhibitors (e.g. clomipramine), SSRIs, selective noradrenaline reuptake inhibitors, CBT, or a combination of CBT...

Additional file 10. Metabolites significantly changed with increased N-formylmethionine abundance in VITdAL-ICU Cohort placebo patients over days 0, 3 and 7.

Additional file 3. Associations between plasma N-formylmethionine abundance quartiles and 28-day mortality. Logistic regression models shown for crude and adjusted VITdAL-ICU and RoCI cohort survival data. Additional models shown with adjustment for total bilirubin, creatinine, and/or propofol exposure.

Additional file 11. Day 0 N-formylmethionine-specific Metabolic Networks with similar effects via Gaussian graphical models.

Additional file 9. Metabolites significantly changed with increased N-formylmethionine abundance in the VITdAL-ICU Cohort over days 0, 3 and 7.

Additional file 1: Table S1. Screening experiments of four macromolecules (CaSO4, MgCl2, PO43−, and NH4Cl) with one factor at a time screening strategy (A, B, C, D, E) and combination of high levels of two factors at a time and keeping others at the concentrations in the original DMB medium (BC, BD, BE, CD, CE, DE). Table S2. The growth profile of R. marinus DSM 16675 in DRM medium with different concentration of glucose as...

Additional file 24: Figure S9. Comparison of effect size estimates between males and females for index variants showing a significant difference in effect size between sexes.

Additional file 16: Figure S8. PheWAS meta-analysis results for the trans-ethnic nonHDL-C PGS in UK Biobank and MVP.

Additional file 31: Supplementary Note. Supplementary Note and Cohort Acknowledgments.

Additional file 1. Description of data (reference: https://bmcmedicine.biomedcentral.com/submission-guidelines/preparing-your-manuscript#preparing+additional+files ).

Objective: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. Methods: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: <30, 30–44, >44), DAS28-CRP (low/moderate/high: ≤2.67, >2.67–4.09, >4.09) and CRP (low/moderate/high: ≤10, >10–30, >30 mg/L), with...

Additional file 9: Figure S3. Lipid traits – tissue/cell type associations estimated by DESE according to GTEx gene-level and GTEx transcript-level selective expression.

Additional file 11: Figure S4. Comparison of PheWAS results in UKB and MVP for the LDL-C PGS, HDL-C PGS, TC PGS, TG PGS and nonHDL-C PGS.

Additional file 14: Figure S6. PheWAS meta-analysis results for the trans-ethnic TC PGS in UK Biobank and MVP.

To assess the efficacy and safety of selective serotonin reuptake inhibitors (SSRIs) and selective noradrenaline reuptake inhibitors (SNRIs) in comparison with various control contingencies (e.g. pill placebo and cognitive behavioral treatment) for pediatric anxiety disorders. Additionally, we wanted to investigate whether serious adverse events or adverse events are more common with medication treatment compared with pill placebo. Studies were selected if they were randomized controlled trials evaluating SSRIs or SNRIs. Eligible studies included participants aged...

To assess the efficacy and safety of selective serotonin reuptake inhibitors (SSRIs) and selective noradrenaline reuptake inhibitors (SNRIs) in comparison with various control contingencies (e.g. pill placebo and cognitive behavioral treatment) for pediatric anxiety disorders. Additionally, we wanted to investigate whether serious adverse events or adverse events are more common with medication treatment compared with pill placebo. Studies were selected if they were randomized controlled trials evaluating SSRIs or SNRIs. Eligible studies included participants aged...

Additional file 12. Significantly Different Metabolites with increased N-formylmethionine abundance in the RoCI Cohort at day 0.

Additional file 6. Day 0 OPLS-DA model goodness of fit, predictive ability and model significance in both VITdAL-ICU and RoCI Cohorts. R2 and Q2 quality metrics, the permutation diagnostics and overall model significance are presented.

Additional file 2. Admission Diagnosis category of VITdAL-ICU cohort patients by day 0 N-Formylmethionine abundance quartiles.

Additional file 9. Metabolites significantly changed with increased N-formylmethionine abundance in the VITdAL-ICU Cohort over days 0, 3 and 7.

Additional file 34. Review history.

Women are exposed to a variety of life stressors, particularly violence, during their lifetime which increases the risk of developing various psychiatric and somatic diseases, with the dysregulated secretion of cortisol as one potential biological mechanism. We examined the association between violence and other life stressors and hair cortisol concentration (HCC) in a population of urban women. We included 470 adult women (age = 21–86 years) attending the Cancer Detection Clinic in Iceland. The Life...

Women are exposed to a variety of life stressors, particularly violence, during their lifetime which increases the risk of developing various psychiatric and somatic diseases, with the dysregulated secretion of cortisol as one potential biological mechanism. We examined the association between violence and other life stressors and hair cortisol concentration (HCC) in a population of urban women. We included 470 adult women (age = 21–86 years) attending the Cancer Detection Clinic in Iceland. The Life...