12 Works

Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

Iker Valle Aramburu, Dennis Hoving, Spyros I Vernardis, Martha CF Tin, Marianna Ioannou, Mia I Temkin, Nathalia M De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T Chiesa, John E Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser & Venizelos Papayannopoulos
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation of DNase I or the actin scavenger gelsolin. Splenocyte death and neutrophil extracellular trap (NET) clearance deficiencies were prevalent in individuals with severe COVID-19...

sj-docx-1-hpq-10.1177_13591053221149526 – for Promoting prosociality toward future generations in antibiotic intake

Ana Paula Santana, Lars Korn, Cornelia Betsch & Robert Böhm
sj-docx-1-hpq-10.1177_13591053221149526 for Promoting prosociality toward future generations in antibiotic intake by Ana Paula Santana, Lars Korn, Cornelia Betsch and Robert Böhm in Journal of Health Psychology

sj-docx-1-scx-10.1177_10755470221129608 – Supplemental material for Benefits and Pitfalls of Debunking Interventions to Counter mRNA Vaccination Misinformation During the COVID-19 Pandemic

Philipp Schmid & Cornelia Betsch
Supplemental material, sj-docx-1-scx-10.1177_10755470221129608 for Benefits and Pitfalls of Debunking Interventions to Counter mRNA Vaccination Misinformation During the COVID-19 Pandemic by Philipp Schmid and Cornelia Betsch in Science Communication

Additional file 1 of Effects of mosquito resting site temperatures on the estimation of pathogen development rates in near-natural habitats in Germany

Felix Gregor Sauer, Ellen Kiel & Renke Lühken
Additional file 1: Table S1. Results of the multiple linear regressions to predict the resting site temperatures in the two habitats meadows and forest for both study periods. Table S2. Mean number (with 95% confidence interval) of specimens per species collected per resting site type and height level. Total number resting site sampling events: 5043 (3213 in artificial resting sites and 1830 in natural resting sites).

sj-docx-1-hpq-10.1177_13591053221149526 – for Promoting prosociality toward future generations in antibiotic intake

Ana Paula Santana, Lars Korn, Cornelia Betsch & Robert Böhm
sj-docx-1-hpq-10.1177_13591053221149526 for Promoting prosociality toward future generations in antibiotic intake by Ana Paula Santana, Lars Korn, Cornelia Betsch and Robert Böhm in Journal of Health Psychology

sj-docx-1-scx-10.1177_10755470221129608 – Supplemental material for Benefits and Pitfalls of Debunking Interventions to Counter mRNA Vaccination Misinformation During the COVID-19 Pandemic

Philipp Schmid & Cornelia Betsch
Supplemental material, sj-docx-1-scx-10.1177_10755470221129608 for Benefits and Pitfalls of Debunking Interventions to Counter mRNA Vaccination Misinformation During the COVID-19 Pandemic by Philipp Schmid and Cornelia Betsch in Science Communication

Additional file 1 of How a generally well-accepted measles vaccine mandate may lead to inequities and decreased vaccine uptake: a preregistered survey study in Germany

Julia Neufeind, Nora Schmid-Küpke, Eva Rehfuess, Cornelia Betsch & Ole Wichmann
Additional file 1: Supplementary Figure 1. Directed acyclic graph (DAG) on hypothesis 2: Higher reactance to the measles mandate among parents decreases uptake of other vaccines and the intention to vaccinate children against other diseases. Supplementary Table 1. ANCOVA results for socio-economic status (income) and for knowledge about the measles vaccine mandate and the measles vaccine. Supplementary Table 2. ANCOVA results for socio-economic status (education) and for knowledge about the measles vaccine mandate and the...

Additional file 1 of How a generally well-accepted measles vaccine mandate may lead to inequities and decreased vaccine uptake: a preregistered survey study in Germany

Julia Neufeind, Nora Schmid-Küpke, Eva Rehfuess, Cornelia Betsch & Ole Wichmann
Additional file 1: Supplementary Figure 1. Directed acyclic graph (DAG) on hypothesis 2: Higher reactance to the measles mandate among parents decreases uptake of other vaccines and the intention to vaccinate children against other diseases. Supplementary Table 1. ANCOVA results for socio-economic status (income) and for knowledge about the measles vaccine mandate and the measles vaccine. Supplementary Table 2. ANCOVA results for socio-economic status (education) and for knowledge about the measles vaccine mandate and the...

Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

Iker Valle Aramburu, Dennis Hoving, Spyros I Vernardis, Martha CF Tin, Marianna Ioannou, Mia I Temkin, Nathalia M De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T Chiesa, John E Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser & Venizelos Papayannopoulos
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation of DNase I or the actin scavenger gelsolin. Splenocyte death and neutrophil extracellular trap (NET) clearance deficiencies were prevalent in individuals with severe COVID-19...

sj-pdf-3-hpq-10.1177_13591053221149526 – Supplemental material for Promoting prosociality toward future generations in antibiotic intake

Ana Paula Santana, Lars Korn, Cornelia Betsch & Robert Böhm
Supplemental material, sj-pdf-3-hpq-10.1177_13591053221149526 for Promoting prosociality toward future generations in antibiotic intake by Ana Paula Santana, Lars Korn, Cornelia Betsch and Robert Böhm in Journal of Health Psychology

Additional file 1 of Effects of mosquito resting site temperatures on the estimation of pathogen development rates in near-natural habitats in Germany

Felix Gregor Sauer, Ellen Kiel & Renke Lühken
Additional file 1: Table S1. Results of the multiple linear regressions to predict the resting site temperatures in the two habitats meadows and forest for both study periods. Table S2. Mean number (with 95% confidence interval) of specimens per species collected per resting site type and height level. Total number resting site sampling events: 5043 (3213 in artificial resting sites and 1830 in natural resting sites).

sj-pdf-3-hpq-10.1177_13591053221149526 – Supplemental material for Promoting prosociality toward future generations in antibiotic intake

Ana Paula Santana, Lars Korn, Cornelia Betsch & Robert Böhm
Supplemental material, sj-pdf-3-hpq-10.1177_13591053221149526 for Promoting prosociality toward future generations in antibiotic intake by Ana Paula Santana, Lars Korn, Cornelia Betsch and Robert Böhm in Journal of Health Psychology

Registration Year

  • 2023
    4
  • 2022
    8

Resource Types

  • Text
    12

Affiliations

  • Bernhard Nocht Institute for Tropical Medicine
    12
  • University of Erfurt
    8
  • University of Bonn
    8
  • University of Copenhagen
    4
  • University of Vienna
    4
  • Charité - University Medicine Berlin
    2
  • Hannover Medical School
    2
  • University of Cambridge
    2
  • University Hospital of Zurich
    2
  • Robert Koch Institute
    2