141 Works

Optimised point estimators for multi-stage single-arm phase II oncology trials

Michael J. Grayling & Adrian P. Mander
The uniform minimum variance unbiased estimator (UMVUE) is, by definition, a solution to removing bias in estimation following a multi-stage single-arm trial with a primary dichotomous outcome. However, the UMVUE is known to have large residual mean squared error (RMSE). Therefore, we develop an optimisation approach to finding estimators with reduced RMSE for many response rates, which attain low bias. We demonstrate that careful choice of the optimisation parameters can lead to an estimator with...

Additional file 6 of Multimorbidity and its socio-economic associations in community-dwelling older adults in rural Tanzania; a cross-sectional study

Emma Grace Lewis, William K. Gray, Richard Walker, Sarah Urasa, Miles Witham & Catherine Dotchin
Additional file 6: Figure 2. The overlap between self-reported multimorbidity, disability and CGA-diagnosed frailty.

Supplemental Material - Longitudinal Predictors of Informant-Rated Involvement of People with Dementia in Everyday Decision-Making: Findings from the IDEAL Program

Serena Sabatini, Anthony Martyr, Laura D. Gamble, Rachel Collins, Fiona E. Matthews, Robin G. Morris, Jennifer M. Rusted, Claire Pentecost, Catherine Quinn & Linda Clare
Supplemental Material for Longitudinal Predictors of Informant-Rated Involvement of People with Dementia in Everyday Decision-Making: Findings from the IDEAL Program by Serena Sabatini, Anthony Martyr, Laura D. Gamble, Rachel Collins, Fiona E. Matthews, Robin G. Morris, Jennifer M. Rusted, Claire Pentecost, Catherine Quinn, and Linda Clare on behalf of the IDEAL study team in Journal of Applied Gerontology

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Additional file 3 of Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy

Alaa Abouhajar, Lisa Alcock, Theophile Bigirumurame, Penny Bradley, Laura Brown, Ian Campbell, Silvia Del Din, Julie Faitg, Gavin Falkous, Gráinne S. Gorman, Rachel Lakey, Robert McFarland, Jane Newman, Lynn Rochester, Vicky Ryan, Hesther Smith, Alison Steel, Renae J. Stefanetti, Huizhong Su, Robert W. Taylor, Naomi J.P. Thomas, Helen Tuppen, Amy E. Vincent, Charlotte Warren & Gillian Watson
Additional file 3. PIS Summary.

Additional file 3 of Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy

Alaa Abouhajar, Lisa Alcock, Theophile Bigirumurame, Penny Bradley, Laura Brown, Ian Campbell, Silvia Del Din, Julie Faitg, Gavin Falkous, Gráinne S. Gorman, Rachel Lakey, Robert McFarland, Jane Newman, Lynn Rochester, Vicky Ryan, Hesther Smith, Alison Steel, Renae J. Stefanetti, Huizhong Su, Robert W. Taylor, Naomi J.P. Thomas, Helen Tuppen, Amy E. Vincent, Charlotte Warren & Gillian Watson
Additional file 3. PIS Summary.

Additional file 16 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y. F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, Heather P. O’Keefe, Aaron Coffin, Amish Patel, Lisa A. Sloan, Darren J. Mitchell, Thomas G. Hayhow, Laurent Lunven, Robert J. Watson, Christopher E. Blunt, Lee A. Harrison, Gordon Bruton, Umesh Kumar, Natalie Hamer, John R. Spaull, Danny A. Zwijnenburg … & Wouter J. de Jonge
Additional file 16. The discovery and the synthesis of GSK761, GSK064, GSK675 and GSK306.

Additional file 3 of Multimorbidity and its socio-economic associations in community-dwelling older adults in rural Tanzania; a cross-sectional study

Emma Grace Lewis, William K. Gray, Richard Walker, Sarah Urasa, Miles Witham & Catherine Dotchin
Additional file 3: Table 3. The prevalence of multimorbidity adjusted for frailty-weighting.

Additional file 4 of Multimorbidity and its socio-economic associations in community-dwelling older adults in rural Tanzania; a cross-sectional study

Emma Grace Lewis, William K. Gray, Richard Walker, Sarah Urasa, Miles Witham & Catherine Dotchin
Additional file 4: Table 4. The CASP-19 quality of life score by demographic and multimorbidity categories.

Additional file 1 of Factors influencing consumption of traditional diets: stakeholder views regarding sago consumption among the indigenous peoples of West Papua

Fathir Fajar Sidiq, David Coles, Carmen Hubbard, Beth Clark & Lynn J. Frewer
Additional file 1. COREQ checklist.

sj-docx-8-npx-10.1177_1934578X221143637 - Supplemental material for Exploring the Potential Mechanism of Danshen in the Treatment of Concurrent Ischemic Heart Disease and Depression Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Xiaowen Dang, Yajie Wang & Lei Huang
Supplemental material, sj-docx-8-npx-10.1177_1934578X221143637 for Exploring the Potential Mechanism of Danshen in the Treatment of Concurrent Ischemic Heart Disease and Depression Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation by Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Xiaowen Dang, Yajie Wang and Lei Huang in Natural Product Communications

sj-docx-8-npx-10.1177_1934578X221143637 - Supplemental material for Exploring the Potential Mechanism of Danshen in the Treatment of Concurrent Ischemic Heart Disease and Depression Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Xiaowen Dang, Yajie Wang & Lei Huang
Supplemental material, sj-docx-8-npx-10.1177_1934578X221143637 for Exploring the Potential Mechanism of Danshen in the Treatment of Concurrent Ischemic Heart Disease and Depression Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation by Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Xiaowen Dang, Yajie Wang and Lei Huang in Natural Product Communications

Additional file 10 of A point-of-care ultrasound education curriculum for pediatric critical care medicine

Vidit Bhargava, Bereketeab Haileselassie, Samuel Rosenblatt, Mark Baker, Kevin Kuo & Erik Su
Additional file 10. Post-course survey to assess the impact of the curriculum on the learners

Additional file 1 of Role of primary care pharmacists in the post-hospital discharge care of patients: a scoping review protocol

Faiza Yahya, Hamde Nazar & Muhammad Abdul Hadi
Additional file 1. JBI 2020 Approach for scoping reviews—9 steps [38].

Additional file 1 of Role of primary care pharmacists in the post-hospital discharge care of patients: a scoping review protocol

Faiza Yahya, Hamde Nazar & Muhammad Abdul Hadi
Additional file 1. JBI 2020 Approach for scoping reviews—9 steps [38].

Supplemental Material - A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection

Mark Krystal, Shiven Chabria, Daren Austin, Allen Wolstenholme, David Wensel, Max Lataillade, Judah Abberbock, Mark Baker & Peter Ackerman
Supplemental Material for A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection by Mark Krystal, Shiven Chabria, Daren Austin, Allen Wolstenholme, David Wensel, Max Lataillade, Judah Abberbock, Mark Baker, Peter Ackerman in Antiviral Therapy.

Supplemental Material - A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection

Mark Krystal, Shiven Chabria, Daren Austin, Allen Wolstenholme, David Wensel, Max Lataillade, Judah Abberbock, Mark Baker & Peter Ackerman
Supplemental Material for A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection by Mark Krystal, Shiven Chabria, Daren Austin, Allen Wolstenholme, David Wensel, Max Lataillade, Judah Abberbock, Mark Baker, Peter Ackerman in Antiviral Therapy.

Supplemental Material - A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection

Mark Krystal, Shiven Chabria, Daren Austin, Allen Wolstenholme, David Wensel, Max Lataillade, Judah Abberbock, Mark Baker & Peter Ackerman
Supplemental Material for A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection by Mark Krystal, Shiven Chabria, Daren Austin, Allen Wolstenholme, David Wensel, Max Lataillade, Judah Abberbock, Mark Baker, Peter Ackerman in Antiviral Therapy.

sj-docx-1-whe-10.1177_17455057221129399 – Supplemental material for Parental intimate partner violence and abuse during the COVID-19 pandemic: Learning from remote and hybrid working to influence future support

Hayley Alderson, Simon Barrett, Michelle Addison, Samantha Burns, Victoria Cooling, Simon Hackett, Eileen Kaner, William McGovern, Deborah Smart & Ruth McGovern
Supplemental material, sj-docx-1-whe-10.1177_17455057221129399 for Parental intimate partner violence and abuse during the COVID-19 pandemic: Learning from remote and hybrid working to influence future support by Hayley Alderson, Simon Barrett, Michelle Addison, Samantha Burns, Victoria Cooling, Simon Hackett, Eileen Kaner, William McGovern, Deborah Smart and Ruth McGovern in Women’s Health

sj-docx-1-whe-10.1177_17455057221129399 – Supplemental material for Parental intimate partner violence and abuse during the COVID-19 pandemic: Learning from remote and hybrid working to influence future support

Hayley Alderson, Simon Barrett, Michelle Addison, Samantha Burns, Victoria Cooling, Simon Hackett, Eileen Kaner, William McGovern, Deborah Smart & Ruth McGovern
Supplemental material, sj-docx-1-whe-10.1177_17455057221129399 for Parental intimate partner violence and abuse during the COVID-19 pandemic: Learning from remote and hybrid working to influence future support by Hayley Alderson, Simon Barrett, Michelle Addison, Samantha Burns, Victoria Cooling, Simon Hackett, Eileen Kaner, William McGovern, Deborah Smart and Ruth McGovern in Women’s Health

What makes an operational farm soil carbon code? Insights from a global comparison of existing soil carbon codes using a structured analytical framework

Helaina I. J. Black, Mark S. Reed, Helen Kendall, Robert Parkhurst, Nicola Cannon, Pippa J. Chapman, Matthew Orman, Jenny Phelps, Hannah Rudman, Sarah Whaley, Jagadeesh Yeluripati & Guy Ziv
Soils have the potential to sequester and store significant amounts of carbon, contributing towards climate change mitigation. Soil carbon markets are emerging to pay farmers for management changes that absorb atmospheric carbon, governed by codes that ensure eligibility, additionality and permanence whilst protecting against leakage and reversals. This paper presents the first global comparative analysis of farmland soil carbon codes, providing new insights into the range of approaches governing this global marketplace. To do this,...

Additional file 2 of Auditory rhythmical cueing to improve gait in community-dwelling stroke survivors (ACTIVATE): a pilot randomised controlled trial

Lisa Shaw, Patricia McCue, Philip Brown, Christopher Buckley, Silvia Del Din, Richard Francis, Heather Hunter, Allen Lambert, Sue Lord, Christopher I. M. Price, Helen Rodgers, Lynn Rochester & Sarah A. Moore
Additional file 2: Figure S2. Example balance training exercise.

Additional file 4 of Auditory rhythmical cueing to improve gait in community-dwelling stroke survivors (ACTIVATE): a pilot randomised controlled trial

Lisa Shaw, Patricia McCue, Philip Brown, Christopher Buckley, Silvia Del Din, Richard Francis, Heather Hunter, Allen Lambert, Sue Lord, Christopher I. M. Price, Helen Rodgers, Lynn Rochester & Sarah A. Moore
Additional file 4: Table S1. Description of the ARC gait and balance training programme using TIDieR checklist.

Additional file 6 of Auditory rhythmical cueing to improve gait in community-dwelling stroke survivors (ACTIVATE): a pilot randomised controlled trial

Lisa Shaw, Patricia McCue, Philip Brown, Christopher Buckley, Silvia Del Din, Richard Francis, Heather Hunter, Allen Lambert, Sue Lord, Christopher I. M. Price, Helen Rodgers, Lynn Rochester & Sarah A. Moore
Additional file 6: Table S3. Training programme provider feedback data.

Additional file 2 of Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Frank W. Roemer, Mylène Jansen, Anne C. A. Marijnissen, Ali Guermazi, Rafael Heiss, Susanne Maschek, Agnes Lalande, Francisco J. Blanco, Francis Berenbaum, Lotte A. van de Stadt, Margreet Kloppenburg, Ida K. Haugen, Christoph H. Ladel, Jaume Bacardit, Anna Wisser, Felix Eckstein, Floris P. J. G. Lafeber, Harrie H. Weinans & Wolfgang Wirth
Additional file 2.

Registration Year

  • 2023
    4
  • 2022
    130
  • 2021
    3
  • 2020
    4

Resource Types

  • Text
    141

Affiliations

  • Newcastle University
    141
  • Royal Victoria Infirmary
    41
  • Newcastle upon Tyne Hospitals NHS Foundation Trust
    24
  • Leiden University Medical Center
    19
  • Universitätsklinikum Erlangen
    18
  • Hôpital Saint-Antoine
    18
  • University of A Coruña
    18
  • Diakonhjemmet Hospital
    18
  • Servier (France)
    18
  • Chondrometrics (Germany)
    18