Two new cycloartane triterpenoid glycosides, soulieoside V (1) and 15-deacetylbeesioside O (2), together with one known compound, beesioside J (3), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. All the compounds were tested for their cytotoxic activities against human cancer cell lines.

Additional file 3: Table S3. KEGG enrichment results of recurrent driver genes in pGI-DLBCL.

Additional file 1: TableS1 Comparison of GMV volume between two groups.

Additional file 11. Fig. S3. The prioritized genes overlapping between the four tools.

Additional file 1: Table S1. The identification of phenolic components in TH.Table S2. Antioxidant capacity of candidate markers. Table S3. The in silico pharmacokinetic parametersof candidate markers. Table S4. Methodology investigation for thequantitation of four markers. Figure S1. Representative UV absorbanceprofile (a), and base peak chromatogram (b). Figure S2. PLSRmodels. The summary of fit (a-c) and permutation tests (d-f) forantioxidative activity by DPPH and FRAP, and anti-inflammatory activity,respectively. Figure S3. The toxicity of luteolin (a),...

Additional file 5. Fig. S1. Gene ontology analysis of the 1249 candidate genes (1129 matched).

A list of SNSPDs and SMSPDs with low polarization sensitivity, coupling efficiency, refractive indices, DCR and FCR, uncertainty, more LiDAR images

Additional file 2. Figure S1. Split-ubiquitin-based yeast two-hybrid (SUB-Y2H) and luciferin (Luc) living fluorescence imaging (LLFI) assays of protein combinations between PthXo1 and different variants of OsIMPα1b and OsIMPα1a (shown as IMPα1b and IMPα1a in this figure). Figure S2. CRISPR/Cas9-based OsIMPα1a gene editing and viability of OsIMPα1a-edited (OsIMPα1a-ED) and OsIMPα1b-edited (OsIMPα1b-ED) rice lines. Figure S3. Plants growing in the specific rice-growing pond and representing plant populations of the wild type (Nipponbare) and OsIMPα1b-edited lines (OsIMPα1b-ED#6...

Capillary dominated flow or imbibition—whether spontaneous or forced—is an important physical phenomena in understanding the behavior of naturally fractured water-driven reservoirs (NFR’s). When the water flows through the fractures, it imbibes into the matrix and pushes the oil out of the pores due to the difference in the capillary pressure. In this paper, we focus on modeling and quantifying the oil recovered from NFR’s through the imbibition processes using a novel fully implicit mimetic finite...

Fenretinide (4-HPR), a synthetic retinoid, has attracted attention for its anti-inflammation activity. However, few studies have evaluated the effects of 4-HPR on ulcerative colitis (UC). The present study was performed to investigate the therapeutic effects of 4-HPR on UC, and to explore the mechanisms mainly focused on macrophage polarization involved in this progress. Intraperitoneally administered 4-HPR particularly at dose of 100 mg/kg obviously alleviated UC symptoms and restrained the mRNA expression of colonic IL-1β, IL-6,...

The existence of blood–brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM is essentially poorly understood. This study found that vascular endothelial growth factor (VEGF) secreted by GBM cells plays an important role in increasing the permeability of BBB by disrupting endothelial tight junction proteins claudin-5...

Co-occurrence of hypervirulence and KPC-2 carbapenem resistant phenotypes in a highly-transmissible ST11 clone ofKlebsiella pneumoniae has elicited deep concerns from public health stand point. To address this puzzle, we conducted a large-scale epidemiological, clinical and genomic study of K. pneumonia ST11 clones with both hypervirulence and carbapenem resistance in two tertiary hospitals in Zhejiang province. Most of the patients (15/23) were diagnosed with exclusively carbapenem-resistant K. pneumoniae (CRKP) infections. Ten death cases were reported, some...

Additional file 4: Table S4. Summary of the statistically significant correlations in the matrix.

In this work, we prepared a stimuli-responsive system for drug delivery and controlled release by engineering the bovine serum albumin (BSA). The doxorubicin (DOX)-loaded BSA nanoparticles (NPs) were conveniently prepared using desolvation method, followed by crosslinking through Schiff base bonds, leading to pH-sensitive DOX-loaded system (DOXs@BSA NPs). The resulted DOXs@BSA NPs showed high drug loading capacity (21.4%), and the particle size was about 130 nm with narrow polydispersity and high negative surface charge (−20.5 mV)....

Three new dibenzofurans, 2-hydroxy-3,4-dimethoxydibenzofuran (1), 2,8-dihydroxy-3,4,9-trimethoxydibenzofuran (5) and 2-hydroxy-3,4,6,8-tetramethoxydibenzofuran (6), together with three known dibenzofurans 1-hydroxy-2,3,4-trimethoxydibenzofuran (2), 2-hydroxy-3,4,6-trimethoxydibenzofuran (3) and 1,6-dihydroxy-2,3,4-trimethoxydibenzofuran (4), were isolated from the twigs and leaves of Crataegus oresbia. Their structures were identified by the comprehensive analyses of the physicochemical properties and spectroscopic data (NMR and HR-ESI-MS). Compounds 1–3 showed significant in vitro lipid-lowering activities, especially compound 3 was stronger than simvastatin.

The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic analysis of public datasets from The Cancer Genome Atlas database (TCGA). The results showed that the expression levels of ZFC3H1 were notably lower than the corresponding non-cancerous tissues in prostate adenocarcinoma (PRAD), and patients in the high ZFC3H1-expression group showed poor survival. We hypothesized that the low expression of ZFC3H1 in tumor tissue might have be...

Capillary dominated flow or imbibition—whether spontaneous or forced—is an important physical phenomena in understanding the behavior of naturally fractured water-driven reservoirs (NFR’s). When the water flows through the fractures, it imbibes into the matrix and pushes the oil out of the pores due to the difference in the capillary pressure. In this paper, we focus on modeling and quantifying the oil recovered from NFR’s through the imbibition processes using a novel fully implicit mimetic finite...

Additional File 1. Figure S1: A representative CT image at the third lumbar vertebra (L3) marked with different body composition. Skeletal muscle (SM) in red; subcutaneous adipose tissue (SAT) in blue; visceral adipose tissue (VAT) in yellow; intramuscular adipose tissue (IMAT) in green. Figure S2: Gene expression distributions of each sample for RNA sequencing. Figure S3: Representative images of SAT and VAT from normal and cachectic mice.

Additional File 2. Table S1: Patients’ characteristics for RNA sequencing. Table S2: Primer Sequences used for qRT-PCR. Table S3: Clinical Characteristics of 61 cachectic patients.

The tree shrew (Tupaia belangeri) is currently placed in the order Scandentia. Owing to their unique characteristics, such as small body size, high brain-to-body mass ratio, short reproductive cycle and life span, and low maintenance costs in laboratory conditions, tree shrews have been proposed as alternative experimental animals to primates in biomedical research. In this study, we determined the complete mitochondrial genome of the subspecies Tupaia belangeri yaoshanensis (T.b. yaoshanensis). The mitochondrial DNA (mtDNA) is...

In preclinical studies, a new antituberculosis drug regimen markedly reduced the time required to achieve relapse-free cure. This study aimed to preliminarily evaluate the efficacy and safety of this four-month regimen, consisting of clofazimine, prothionamide, pyrazinamide and ethambutol, with a standard six-month regimen in patients with drug-susceptible tuberculosis. An open-label pilot randomized clinical trial was conducted among the patients with newly diagnosed bacteriologically-confirmed pulmonary tuberculosis. The primary efficacy end-point was sputum culture negative conversion. Totally,...

Additional file 1. Table S1. Rice importins retrieved from Rice Genome Annotation Project databases. Table S2. Early characterizations of OsIMPα1a-edited (OsIMPα1a-ED) and OsIMPα1b-edited (OsIMPα1b-ED) rice lines. Table S3. Information on genes tested and primers used in this study.

Additional file 2: Supplementary Table 1. Subgroup analysis for the association between categorized BMI and lymph node metastasis.

Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC50 values ranged from 3.69 to 11.84 μM.

Additional file 3. Additional methods. Pathway analysis of the prioritized genes, the databases, and the dataset.