Tick-borne encephalitis virus (TBEV) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia and causes encephalitis in humans. In this study, we demonstrate TBEV appears to activate the interferon (IFN)-β dependent on RIG-I/MDA5. Both the IFN-β accumulation and the IFN stimulated genes (ISGs) transcription greatly delay. Further studies reveal that TBEV NS4A could block the phosphorylation and dimerization of STAT1/STAT2 to affect type I and II IFN-mediated STAT signalling. Additional data...

Supplemental methods

Additional file 2: Clinical stage-specific disability weights and distribution of breast cancer in females in China.

Supplemental document with additional data, simulation results, and figures.

Additional file 1: Appendix 1. Clinicopathologic characteristics of 28 deaths.

Additional file 1: TableS1 Comparison of GMV volume between two groups.

Additional file 1: Supplement Figure 1. Association between the lipophilic index and oral cancer by stratified analysis.

Additional file 2. SAP.

Additional file 3. Informed consent materials.

Additional file 4: Fig. S1. Expressed lncRNAs in two crosses.

Additional file 5: Fig. S2. Expression levels of lncRNAs and PCgenes in sunflower endosperm.

Additional file 7: Fig. S4. DNA methylation profiles of protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

Additional file 1: Table S1. Correlation between selected radiomics features and clinical characteristics listed in Table 1. Table S2. Feature categories used in this study. Supplementary Methods. Radiomics features calculation.

Additional file 1: Table S1. Sequences of siRNAs. Table S2. Primers for ChIP analysis.

Additional file 1: Table S1. Sequences of siRNAs. Table S2. Primers for ChIP analysis.

Additional file 2: Table S2. The average of the inter- specific nucleotide percentage of pairwise identities (mean ± standard deviation%) of each species to all the others at each locus; overall is the average value of all the means across all the species for each locus.

Additional file 12. Supplementary discussion.

Additional file 1. AD-related UMLS concepts used in the study.

Some individuals with acute pancreatitis (AP) suffer from pancreatic necrosis. Diabetes affects the severity of AP, but whether diabetes influences pancreatic necrosis is unclear. This study aims to investigate the clinical characteristics of AP patients with and without diabetes as well as analyze the risk factors of pancreatic necrosis. A total of 625 AP patients participated in the study. Clinical and laboratory data were retrieved. Multivariate logistic regression analysis was used to identify the risk...

Additional file 9: Figure S9. Genome-wide composition of blastocysts following multipolar zygotic division. Circos plots of six embryos that developed to the blastocyst stage following multipolar zygotic division in which each circle represents the interpreted genome constitution per chromosome (1 - X) of a sampled single cell. The interpreted genome spanning the largest part of the chromosome was chosen as overall interpretation per chromosome, as such, segmental chromosomal errors are not depicted. On the left...

Additional file 1. Supplementary Tables and Figures.

Additional file 1: Fig. S1. Conditions for bulk RNA. Fig. S2. Improved performance of SHERRY2 on bulk RNA. Fig. S3. Conditions for single cells. Fig. S4. Accuracy of SHERRY2 for single cells. Fig. S5. Flow cytometry gating of single lymphocytes and single GC B cells. Fig. S6. DNase activity and performance in SHERRY2 library construction. Fig. S7. GC information gained from SHERRY2. Fig. S8. BCR sequences of single GC B cells identified by SHERRY2. Fig....

PLE and PL spectra, PersL decay curves, and TL spectra of the YAGG:Ce annealed in air and H2/Ar; PersL spectra of the YAGG:Ce,Yb annealed in air and H2/Ar measured at 1, 5, and 10 min after excitation; Comparison of the normalized PersL spectra and P

Additional file 1. AD-related UMLS concepts used in the study.