The exploration of non-invasive biomarkers for assessing tumor response is critical to optimize treatment decisions. In this study, we aimed at determining the potential role of RAI14 in the early diagnosis and evaluation of chemotherapy efficacy in triple-negative breast cancer (TNBC). We recruited 116 patients newly diagnosed with breast cancer, 30 patients with benign breast disease and 30 healthy controls. In addition, 57 TNBC patients were collected in serum at different time points (C0, C2...

Additional file 24: Figure S9. Comparison of effect size estimates between males and females for index variants showing a significant difference in effect size between sexes.

Additional file 16: Figure S8. PheWAS meta-analysis results for the trans-ethnic nonHDL-C PGS in UK Biobank and MVP.

Additional file 31: Supplementary Note. Supplementary Note and Cohort Acknowledgments.

Additional file 1. Original data of WB.

Additional file 1: Table S1. Comparisons of our genomic assembly with previous published genomic assembly of Agrostis ipsilon. Table S2. Circadian clock components in genome of Agrosis ipsilon. Table S3. Juvenile hormone regulatory pathway in genome of Agrosis ipsilon. Table S4. Top 10 GSEA enriched pathways after different durations of tethered-flight moths of Agrostis ipsilon. Table S5. Primers used in this study.

Additional file 2: Fig. S1. Life cycle of Agrotis ipsilon and crop damage. Fig. S2. Distribution of 17-mer frequency in Agrotis ipsilon. Fig. S3. Chromosomes of Agrotis ipsilon in cell of testis from fifth instar larvae. Thirty-one pairs (2n = 62) were present at diakinesis during meiosis. Fig. S4. Venn plot of gene function in five databases in Agrotis ipsilon. Fig. S5. Dot plots of syntenic orthologous between A. ipsilon and S. litura. Fig. S6....

Additional file 1: Figure S1. The two principal components of YT VS RT (A) and YM VS RM B. Figure S2. Total ion flow diagram of QC samples and the multi-peak graphs of MRM metabolites. A Total ion flow diagram of QC samples (Positive ions). B Total ion flow diagram of QC samples (Negative ions). C The multi-peak graphs of MRM metabolites (Positive ions). D The multi-peakgraphs of MRM metabolites (Negative ions). Figure S3. Annotate...

Additional file 1: Figure S1. The two principal components of YT VS RT (A) and YM VS RM B. Figure S2. Total ion flow diagram of QC samples and the multi-peak graphs of MRM metabolites. A Total ion flow diagram of QC samples (Positive ions). B Total ion flow diagram of QC samples (Negative ions). C The multi-peak graphs of MRM metabolites (Positive ions). D The multi-peakgraphs of MRM metabolites (Negative ions). Figure S3. Annotate...

Supplementary Material 1

Supplementary Material 1

Additional file 1: Table 1. Clinical characteristics of patients for this study.

Supplemental Material Fabrication of antibacterial polydopamine-carboxymethyl cellulose-Ag nanoparticle hydrogel coating for urinary catheters by Yongwei Cai, Ronghua Gu, Yuhang Dong, Qi Zhao, Ke Zhang, Changyuan Cheng, Hong Yang, Jianxiang Li, and Xinggen Yuan in Journal of Biomaterials Applications

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There is no doubt that leadership within the organizational context is important. A booming leadership development industry and an exponentially expanding leadership literature attest to this. However, ethical and corporate scandals continue to make headlines, and many can relate to the experience of working for uninspiring or even abusive leaders. This suggests we scholars have further work to do in our efforts to improve the practice of leadership. Of particular interest is how we might...

There is no doubt that leadership within the organizational context is important. A booming leadership development industry and an exponentially expanding leadership literature attest to this. However, ethical and corporate scandals continue to make headlines, and many can relate to the experience of working for uninspiring or even abusive leaders. This suggests we scholars have further work to do in our efforts to improve the practice of leadership. Of particular interest is how we might...

Nearly all humans experience acute pain during their lives. Generally, acute pain is short lived, however, up to 20% of adults globally suffer from persistent pain. This prevalence increases with age with up to 50% of elderly people in the community setting and 80% in aged care facilities (ACFs) experiencing persistent pain. Pain, whether acute or persistent can create a significant burden and cost to the patient and society as a whole, through reduced work...

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This dissertation examines an aspect of colonial history little known outside academic circles: the ethnographic exhibition, predominantly in Europe and America, of living people promoted as being from far-away lands, “exotic” or “savage”. Although research in the last two decades by Poignant, Blanchard, Boëtsch, Bancel, Thode-Arora, Qureshi and others has gathered important historical material about such exhibitions and their role in the construction of racial stereotypes, there remain significant gaps in the record – namely,...

The mind-body problem is the problem: what is the relationship between mind and body? In this project, I claim that the relationship between the experience of pain and specific physiological mechanisms is best understood as one of type identity. Specifically, the personal experience of pain is an allostatic stress mechanism comprised of interdependent nervous, endocrine and immune operations.

Developmental exposure to stress and dysregulation of the hypothalamic-pituitaryadrenal (HPA) axis have been implicated in the onset and course of schizophrenia and bipolar disorder. It is not known to what extent molecular changes in cortical stress response pathways are present in psychotic illness. Promising targets for investigation of stress-related molecular pathology in psychiatric illness are the glucocorticoid receptor (GR) and its chaperones, which together mediate cellular stress responses and control HPA axis activation. In this...

Throughout modernity, portraiture sought to represent the unique essence of an individual. However ideas of self and identity have been subsequently dismantled by postmodern theory within sociology, psychology, feminist theory and post-colonial studies, leaving the concept of self to be considered as a nonessential product of biological, social and psychological fragments. This shift in philosophies of self, or what Martin and Barresi have referred to as the Fall of the Self, has led to a...

One of the biggest challenges facing the world today is how we feed an everincreasing population while reducing greenhouse gas (GHG) emissions that are contributing to global warming. Unquestionably, the livestock sector represents a significant source of emissions, generating carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O). In 1988, the Intergovernmental Panel on Climate Change (IPCC) was established to prepare a comprehensive review and recommendations concerning to the state of the science of climate...

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