Additional file 1. Concept maps developed in NVivo12 as part of the “interpretation” phase of analysis.

Additional file 1. Clinical endpoints in Pronmed and Biobanque Québécoise de la COVID-19 (BQC19) for outcomes of acute COVID-19 and Long COVID-19 clustered as physical or mental symptoms.

Additional file 5: Fig. S5. Validation of the association between risk score and immune cell infiltration. A Scatter plot showed the positive correlation between the risk score and ImmuneScore (Spearman’s rank correlation coefficient) in the GSE16011 GBM cohort. B Scatter plot showed the positive correlation between the risk score and StromalScore (Spearman’s rank correlation coefficient) in the GSE16011 GBM cohort. C Scatter plot showed the positive correlation between the risk score and ESTAMEScore (Spearman’s rank...

Additional file 2: Fig. S2. The predictivity of 12 DE-MRGs model for other cancers. A The univariate cox analysis showed that the risk score, based on our 12 DE-MRGs, significantly associated with other 12 types of TCGA cancers. B Kaplan–Meier curves for OS in the other 12 types of TCGA cancers. The patients were divided in to high- and low-risk groups based on the median value of risk score.

This study seeks to assess the quality of HEEs reporting on screening programs over the last 20 years in China, to identify potential predictors of reporting quality. We performed a literature search of HEE studies published in PubMed, Embase, CNKI, and WANFANG from 2000 to 2021. The search terms included ‘screening,’ ‘China,’ ‘CEA,’ ‘CBA,’ ‘CUA,’ and all other names for health economic evaluation. Two reviewers independently extracted data and assessed the reporting quality using CHEERS...

Additional file 4. The Risk Of Bias In Non-randomized Studies–of Interventions (ROBINS-I) assessment tool.

Additional file 1: Table S1. Composition and nutrient levels of the basal diet.

Additional file 2: Table S2. Primer sequences for quantitative real-time PCR and real-time PCR analyses.

Additional file 3. Effective Practice and Organisation of Care (EPOC). Data collection form. EPOC Resources for review authors. Oslo: Norwegian Knowledge Centre for the Health Services; 2013.

Additional file 7: Count of horizontal gene transfer events within the core genes of V. cholerae and V. metoecus.

Additional file 7: Count of horizontal gene transfer events within the core genes of V. cholerae and V. metoecus.

Additional file 8: Count of horizontal gene transfer events within the accessory genes of V. cholerae and V. metoecus.

Additional file 9: Presence/absence map of genes involved in DNA uptake and restriction-modification, as well as endo- and exonucleases in V. cholerae and V. metoecus.

Additional file 1. PRISMA 2009 Checklist and the ENTREQ statement.

Additional file 3. Decisional needs cases description.

Additional file 1. Supplementary Material and Methods.

Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA demethylase that regulates cellular function and differentiation potential. Macroautophagy/autophagy maintains cellular homeostasis by recycling unnecessary and damaged organelles. This study revealed that TET2 promoted bone loss in oophorectomized (OVX) mice and that TET2 promoted osteoclast differentiation by regulating autophagy. Tet2 knockdown inhibited autophagy and osteoclast differentiation in vitro. Mechanistically, Tet2 knockdown increased...

Additional file 2. PRISMA-P 2015 checklist.

Additional file 3. Search strategies.

Three new annonaceous acetogenins, annotemoyin L (1), annotemoyin Y (2) and annotemoyin X, (3) were isolated from the seeds of Annona squamosa Linn. Their structures were ascertained by chemical methods and spectral data. The cytotoxic activities of compounds against three multidrug-resistant cancer cell lines were evaluated, and compound 3 exerted strong cytotoxicity against SMMC 7721/ADR (IC50 0.163 μM), A549/T (IC50 0.064 μM) and MCF-7/ADR (IC50 0.057 μM).

Ecological quality assessment is fundamental to revealing changes in ecological environments before the development of effective ecological conservation policies. The complex ecological environment can be assessed more reliably when multiple remote sensing indices are integrated, such as in the use of the prevalent Remote Sensing-based Ecological Index (RSEI). However, for effective ecological quality assessment, the requirement of acquisition time consistency for images has become an outstanding issue for broadening the application of the RSEI. In...

Additional file1: Fig. S1. OUM1 knockdown impairs UM cell metastasis and proliferation. Fig. S2. GO and pathway function analysis. Fig. S3. Bioinformatics analysis of OUM1 targets. Fig. S4. PTPRZ1 might be a target of OUM1. Fig. S5. Synergistic effect of SOV and OUM1 interference on apoptosis. Fig. S6. In vivo toxicity evaluation. Table S1. Downregulated and Upregulated gene. Table S2. Primers and siRNA used in this study. Table S3. Primers used in RNA-ChIP assay. Details...

Additional file 1. Covariate Categories. Details on the operationalization of covariate variables.

We identified relapsing fever (RF) Borrelia in 1.45% (145/10426) of the ticks and 1.40% (40/2850) of the wild mammals in a field investigation in China. Three RF Borrelia species, including human-pathogenic Borrelia miyamotoi, Borrelia persica and unclassified Babesia sp. were determined. Main species determined from ticks was B. miyamotoi (44.14%), followed by the unclassified Borrelia sp. (42.76%), and Borrelia theileri (13.10%). In wild mammals, main species found was B. persica (57.50%), followed by the unclassified...

Additional file 4: Table S1. Synthetic lethal interactive pairs and chemical inhibitors involving SWI/SNF members.