Additional file 2: Fig S2. Calibration curves of radiomics model.

Additional file 2: Fig S2. Calibration curves of radiomics model.

Additional file 3. Table S1. Summary of radiomic features.

Supplementary Material 1

Objective: To provide a detailed and differentiated description of the path to receiving the correct amyotrophic lateral sclerosis (ALS) diagnosis, including delay times, referrals, alternate diagnoses, and clinical progression. Methods: Medical records until the date of ALS diagnosis were reviewed and linked to the Swedish Motor Neuron Disease Quality Registry. Results: The study included 353 Stockholm ALS patients diagnosed in 2016–2021. Patients were divided into four groups: 117 (33.1%) with lower extremity (LE), 85 (24.1%)...

Objective: To provide a detailed and differentiated description of the path to receiving the correct amyotrophic lateral sclerosis (ALS) diagnosis, including delay times, referrals, alternate diagnoses, and clinical progression. Methods: Medical records until the date of ALS diagnosis were reviewed and linked to the Swedish Motor Neuron Disease Quality Registry. Results: The study included 353 Stockholm ALS patients diagnosed in 2016–2021. Patients were divided into four groups: 117 (33.1%) with lower extremity (LE), 85 (24.1%)...

Hydroquinone (H2Q) present in water is becoming a growing problem in both daily life and industry, with various harmful effects on human health. Therefore, the detection of H2Q is very important. The Carbon dot-based sensor is considered an effective method to detect H2Q. In this work, Pericarpium citri reticulatae carbon dots (P-CDs) were synthesized by a one-pot hydrothermal method for wide linear sensing of H2Q. An orthogonal test was used to expand the active site...

Plastin 3 (PLS3) overexpression may serve as a marker for predicting chemotherapeutic outcomes in drug-resistant cancer cells, but the mechanism is unclear. Herein, we show that the down-regulation of PLS3 by PLS3 gene silencing augments the sensitivity of MDA-MB-231 triple-negative breast cancer cells to paclitaxel. Interestingly, a low concentration of paclitaxel was able to induce strong apoptosis in the PLS3-silenced cells. Further study revealed that p38 MAPK signalling was responsible for the increased sensitivity to...

Plastin 3 (PLS3) overexpression may serve as a marker for predicting chemotherapeutic outcomes in drug-resistant cancer cells, but the mechanism is unclear. Herein, we show that the down-regulation of PLS3 by PLS3 gene silencing augments the sensitivity of MDA-MB-231 triple-negative breast cancer cells to paclitaxel. Interestingly, a low concentration of paclitaxel was able to induce strong apoptosis in the PLS3-silenced cells. Further study revealed that p38 MAPK signalling was responsible for the increased sensitivity to...

Schizophrenia and bipolar disorder are severe chronic neuropsychiatric diseases, affecting hundreds of millions of people worldwide. Asenapine maleate (ASM) has been demonstrated as a safe and effective therapeutic agent under twice-daily administration. However, lower compliance is observed when patients are treated with ASM, which significantly limits its application in schizophrenia and bipolar disorder. Moreover, the low bioavailability of ASM caused by first-pass metabolism and poor aqueous solubility also impairs the treatment effect. A formulation of...

Stimuli-responsive drug delivery systems (DDSs) are expected to realize site-specific drug release and kill cancer cells selectively. In this study, a pH-responsive micelle was designed utilizing the pH-sensitivity of borate bonds formed between dopamine and boronic acid. First, methyl (polyethylene glycol)-block-polycaprolactone (mPEG-PCL) was conjugated with 4-cyano-4-(thiobenzoylthio)pentanoic acid (CTP) to obtain a macroinitiator. Two different segments poly(dopamine methacrylamide) (PDMA) and poly(vinylphenylboronic acid) (PVBA) were then grafted to the end of mPEG-PCL. Two triblock copolymers, mPEG-PCL-PDMA and...

A Schiff-base type fluorescent sensor (PLB3) was synthesized by nucleophilic addition-elimination between 2-hydroxy-1-naphthaldehyde and 5-chloro-2-aminopyridine. Single crystal X-ray diffraction analysis demonstrated keto-amine isomer was predominantly adopted. 8-Fold fluorescence-enhanced recognition for detecting Zn2+ was chelation enhanced fluoresce (CHEF) mechanism. Also, PLB3 could distinguish well Zn2+ from analogue Cd2+. Job’s plot fluorescence titration and UV–Vis titration revealed the 1:1 stoichiometry between Zn2+ and PLB3. The association constant (Ka) and limit of detection (LOD) were 5.14 × 107...

Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. The viability and Hif-1α levels of microglia and neurons at 5% O2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin,...

Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. The viability and Hif-1α levels of microglia and neurons at 5% O2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin,...

Background: Coronavirus disease 2019 (COVID-19) can place an immense psychological strain on the infected patient. The psychological distress can linger after the initial recovery from the infection. Objective: This study aimed to evaluate the prevalence and predictors of provisional post-traumatic stress disorder (PTSD) in patients with cured COVID-2019. Methods: The baseline survey was conducted from 10 to 25 February 2020 in patients with COVID-19 in a designated hospital. Demographic and clinical characteristics were acquired, and...

Additional file 1: Table S1. Search strategies applied in each bibliographic database. Table S2. Characteristic of studies included in the present study for analyzing risk of incident diabetes post-COVID-19 versus matched controls. Table S3. Quality assessment of included studies with the Newcastle–Ottawa Scale. Figure S1. Subgroup analysis of diabetes type. Figure S2. Subgroup analysis to whether the control group was or was not upper respiratory tract infections. Figure S3. Forest plot showing the incidence of...

Supplementary Material 1. Supplementary Table 1. Transtheoretical Model and stages of change-oriented lifestyle intervention strategies and measures for simple fatty liver disease patients. Supplementary Table 2. Comparison of healthy behavior levels of the 2 groups (controls vs. transtheoretical model and stages of change) before and after intervention.

Additional file 2: Table S1.Information on the imported isolates of P. vivax samples used in this study.

Additional file 11. Fig. S3. The prioritized genes overlapping between the four tools.

Additional file 5. Fig. S1. Gene ontology analysis of the 1249 candidate genes (1129 matched).

Heterotopic pregnancy (HP) is a rare but potentially life-threatening event with a high risk of maternal death, which also jeopardise the coexisting intrauterine pregnancy (IUP), thus an early accurate diagnosis and prompt treatment can decrease adverse complications. We aimed to explore the early predictors for pregnancy outcomes of HP. We reviewed patients with HP following assisted reproductive technology in our institution between January 2013 and December 2020. The relationships between pregnancy outcomes and clinical features...

Additional file 2. Figure S1. Split-ubiquitin-based yeast two-hybrid (SUB-Y2H) and luciferin (Luc) living fluorescence imaging (LLFI) assays of protein combinations between PthXo1 and different variants of OsIMPα1b and OsIMPα1a (shown as IMPα1b and IMPα1a in this figure). Figure S2. CRISPR/Cas9-based OsIMPα1a gene editing and viability of OsIMPα1a-edited (OsIMPα1a-ED) and OsIMPα1b-edited (OsIMPα1b-ED) rice lines. Figure S3. Plants growing in the specific rice-growing pond and representing plant populations of the wild type (Nipponbare) and OsIMPα1b-edited lines (OsIMPα1b-ED#6...

supplementary materials

Accurate traffic flow prediction on the urban road network is an indispensable function of Intelligent Transportation Systems (ITS), which is of great significance for urban traffic planning. However, the current traffic flow prediction methods still face many challenges, such as missing values and dynamic spatial relationships in traffic flow. In this study, a dynamic temporal graph neural network considering missing values (D-TGNM) is proposed for traffic flow prediction. First, inspired by the Bidirectional Encoder Representations...

Diseases caused by infections, such as helminth infections or viral infections, pose a major human health problem worldwide. In particular, one key reason why helminths cause long-term health and economic burdens is that there is currently no effective targeted vaccine for human use. B cell responses – resulting in the production of antibody – underpin most successful vaccine designs. This thesis uncovered MLL1 as a novel regulator of B cell responses to different pathogens, and...