Additional file 1 Figure S1. Sequence data qualitycontrol before transcriptomics analysis. A-B: Representativeimagines showing error rate distribution along sequencedata (reads). C-D: Representative pie graphs showing the classification of raw readsfilter. E-F: Representative imagines showing bases content alongsequence reads. Figure S2. Genomemapping, gene expression distribution and pearson correlation between samples.A-B: Representative pie graphs showing thepercentage of genome regions based on the reads mapping. C: box plotdisplaying the distribution of gene expression levels in different samplesafter calculating...

Plastin 3 (PLS3) overexpression may serve as a marker for predicting chemotherapeutic outcomes in drug-resistant cancer cells, but the mechanism is unclear. Herein, we show that the down-regulation of PLS3 by PLS3 gene silencing augments the sensitivity of MDA-MB-231 triple-negative breast cancer cells to paclitaxel. Interestingly, a low concentration of paclitaxel was able to induce strong apoptosis in the PLS3-silenced cells. Further study revealed that p38 MAPK signalling was responsible for the increased sensitivity to...

Plastin 3 (PLS3) overexpression may serve as a marker for predicting chemotherapeutic outcomes in drug-resistant cancer cells, but the mechanism is unclear. Herein, we show that the down-regulation of PLS3 by PLS3 gene silencing augments the sensitivity of MDA-MB-231 triple-negative breast cancer cells to paclitaxel. Interestingly, a low concentration of paclitaxel was able to induce strong apoptosis in the PLS3-silenced cells. Further study revealed that p38 MAPK signalling was responsible for the increased sensitivity to...

The receptor-binding domain (RBD) of SARS-CoV-2 S protein is proved to be the major target of neutralizing antibodies. However, on the S protein, only a portion of epitopes in RBD can be effectively displayed with dynamic changes in spatial conformations. Using RBD fragment as antigen can better expose the neutralizing epitopes, but the immunogenicity of RBD monomer is suboptimal. Multimeric display of RBD molecules is a feasible strategy to optimize RBD-based vaccines. In this study,...

The receptor-binding domain (RBD) of SARS-CoV-2 S protein is proved to be the major target of neutralizing antibodies. However, on the S protein, only a portion of epitopes in RBD can be effectively displayed with dynamic changes in spatial conformations. Using RBD fragment as antigen can better expose the neutralizing epitopes, but the immunogenicity of RBD monomer is suboptimal. Multimeric display of RBD molecules is a feasible strategy to optimize RBD-based vaccines. In this study,...

Additional file 2: Table S1.Information on the imported isolates of P. vivax samples used in this study.

Hydroquinone (H2Q) present in water is becoming a growing problem in both daily life and industry, with various harmful effects on human health. Therefore, the detection of H2Q is very important. The Carbon dot-based sensor is considered an effective method to detect H2Q. In this work, Pericarpium citri reticulatae carbon dots (P-CDs) were synthesized by a one-pot hydrothermal method for wide linear sensing of H2Q. An orthogonal test was used to expand the active site...

Supplementary Material 1

Additional file 1: Supplementary Fig. 1 m6A gene expression between UCEC patients with or without mutations in m6A regulators. *, P < 0.05; **, P < 0.01.

Additional file 1: Supplementary Fig. 1 m6A gene expression between UCEC patients with or without mutations in m6A regulators. *, P < 0.05; **, P < 0.01.

Additional file 1: Figure S1. Identification of ADMSCyoung and ADMSCold by flow cytometric analysis by surface markers of ADMSCs.Figure S2. H&E staining of live and kidney cells in the control, TGF-β1, TGF-β1+ADMSCyoung-EV and TGF-β1+ADMSCold-EV tenocyte groups 4 weeks after treatment. Scale bar = 100 μm. Figure S3. Blood biochemistry examination of the control, TGF-β1, TGF-β1+ADMSCyoung-EV and TGF-β1+ADMSCold-EV tenocyte groups 4 weeks after treatment, n = 4. Blood chemistry data suggested no hepatic disorder induced by...

Additional file 1. Correcting horizontal distortions of cups on lateral EOS films.

Additional file 1: Fig S1. Representative flow cytometry gating strategy for early-exhausted (PD-1int) and terminally-exhausted (PD-1hi) CD8+ T cells isolated from the tumor of a LLC mouse.

Additional file 2: Fig S2. Calibration curves of radiomics model.

Additional file 2: Fig S2. Calibration curves of radiomics model.

Additional file 3. Table S1. Summary of radiomic features.

Additional file 1: Table S1. Relationship between IR and other clinical phenotypes in patients with PCOS.

Additional file 1: Fig. S1. Putative of transcription factors (TFs) and transcriptional regulators (TRs) by iTAK. Fig. S2. Prediction of long-non-coding RNAs (LncRNA) by CPC (Coding Potential Calculator), CNCI (Coding-Non-Coding Index) software and pfam protein structure domain database. Fig. S3. MTP Iso-Seq data mapped onto the maize reference genome (RefGen.v4). (A) 10 chromosomes of maize. (B) Transcript density of T. dactyloides in each chromosome. (C) Transcript density of Teosinte (D) Gene density of sorghum in...

Additional file 34. Review history.

Additional file 1: Supplementary Table 1. The Keith-Wagener-Barker classification for hypertensive retinopathy.

Additional file 2: Supplementary Table 1. Primer sequences for RT-qPCR.

Additional file 2. Figure S1. Bone marrow smear diagram and representative images of AML subtypes; Figure S2. Distribution of dual-center test dataset in the study; Figure S3. AMLnet diagnostic pipeline; Figure S4. Performance of the AMLnet on image and patient level in the test set; Figure S5. Visualization of AMLnet Gradients in Discriminating AML Subtypes M1, M2a, M2b, and M4; Table S1. Characteristics of patients in the developmental and dual-center test datasets; Table S2. Subtype-wise...

Additional file 1.

Additional file 1: Supplementary Table 1. Baseline characteristics of BBPV patients with and without psychological conditions. Supplementary Table 2. Co-occurrence of psychological conditions. Supplementary Table 3. Survival table of the first BPPV recurrence in rBPPV patients with OCD (N=19). Supplementary Table 4. Cox regression results on the associations between anxiety and the first recurrence of BPPV, comparing BPPV patients with anxiety only with BPPV patients with no anxiety, insomnia or OCD. Supplementary Table 5. Cox...

Additional file 1: Table S1. Detailed sampling information of 27 Juglans regia populations across the Iranian Plateau. Table S2. Detailed information for the 31 pairs of primers and their combination for multiplex PCR. Table S3. Population pairwise FST and Nei’s genetic distance (DA). Lower-left part: FST; upper-right part: DA. Table S4. Gene flow (Nm) among populations. Fig. S1. Neighbor-joining tree of 508 individuals, colors correspond to Fig. 4. The designation of G1 and G2 corresponds...