157 Works

Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups

Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin & You-Zhi Tang
A series of pleuromutilin derivatives containing alkylamine and nitrogen heterocycle groups were designed and synthesised under mild conditions. The in vitro antibacterial activity of these semisynthetic derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, S.aureus ATCC 29213, S.aureus AD3, and S.aureus 144) were evaluated by the broth dilution method. Compound 13 was found to have excellent antibacterial activity against MRSA (MIC = 0.0625 μg/mL). Furthermore, compound 13 was further studied by the time-killing...

Additional file 4 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 4. miRNA sequences.

Additional file 5 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 5. Coding Sequence of Irak1 and Traf6 Genes.

Additional file 1 of A genetic map of the chromatin regulators to drug response in cancer cells

Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi & Yunyan Gu
Additional file 1: Fig. S1. Lung cancer cell lines with RB1 mutations are resistant to CDK4/6 inhibitor, Fig. S2. Sensitive biomarkers interacted with CHEK1 in large intestine cancer cell lines, Fig. S3. Resistant biomarkers interacted with CHEK1 in lung cancer cell lines, Fig. S4. Functional analysis of the CRs genetic interaction, Fig. S5. Differential chromatin accessibility for CSL interactions, Fig. S6. Differential chromatin accessibility for CSV interactions, Fig. S7. TUBA1C subnetwork in drug related CSL...

Maintenance mechanisms of child restraint system use based on the health action process approach theory: Evidence from China

Kangkang Zhang, Li Liu, Ting Zhang, Chi Zhang, Xinpeng Xu, Qifeng Wu & Hua You
Adherence to the use of child restraint system (CRS) can greatly reduce child casualties in road traffic accidents. This study aims to develop the behavior maintenance model of CRS use based on the health action process approach (HAPA) theory to explore the maintenance mechanisms, suggesting appropriate intervention strategies. Adopting the multi-stage stratified cluster random sampling method, a cross-sectional survey for guardians recruited from kindergarten and primary school was conducted using the questionnaire developed based on...

Additional file 11 of Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation

Bo Sun, Shan Jiang, Mingli Li, Yan Zhang, Yanyan Zhou, Xiaolu Wei, Hongjie Wang, Nan Si, Baolin Bian & Haiyu Zhao
Additional file 11: Fig. S4. KEGG enrichment bubble diagram (G31 vs. G38, G38 vs. G32, G42 vs. G46). (A) and (B) showed the top 30 pathways of significant enrichment of the up-and down- regulated DEGs on KEGG for G31 vs. G38, (C) and (D) showed for G38 vs. G42, and (E) and (F) showed for G42 vs. G46.

Additional file 15 of Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation

Bo Sun, Shan Jiang, Mingli Li, Yan Zhang, Yanyan Zhou, Xiaolu Wei, Hongjie Wang, Nan Si, Baolin Bian & Haiyu Zhao
Additional file 15: Fig. S8. Enrichment analysis of DEGs for BD accumulation. (A) By comparing G46 with G31, G38 and G42 respectively, 3260 common DEGs were identified. (B) and (C) showed the top 30 GO terms and pathways of significant enrichment of the BDs-related DEGs.

Additional file 10 of Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation

Bo Sun, Shan Jiang, Mingli Li, Yan Zhang, Yanyan Zhou, Xiaolu Wei, Hongjie Wang, Nan Si, Baolin Bian & Haiyu Zhao
Additional file 10: Fig. S3. GO enrichment bubble diagram (G31 vs. G38, G38 vs. G42, G42 vs. G46). (A) and (B) showed the top 30 pathways of significant enrichment of the upregulated and downregulated DEGs on GO for G31 vs. G38, (C) and (D) showed for G38 vs. G42, and (E) and (F) showed for G42 vs. G46.

Additional file 15 of Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation

Bo Sun, Shan Jiang, Mingli Li, Yan Zhang, Yanyan Zhou, Xiaolu Wei, Hongjie Wang, Nan Si, Baolin Bian & Haiyu Zhao
Additional file 15: Fig. S8. Enrichment analysis of DEGs for BD accumulation. (A) By comparing G46 with G31, G38 and G42 respectively, 3260 common DEGs were identified. (B) and (C) showed the top 30 GO terms and pathways of significant enrichment of the BDs-related DEGs.

Additional file 3 of Copy number variant analysis for syndromic congenital heart disease in the Chinese population

Ping Li, Weicheng Chen, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Han Gao, Meijiao Suo, Ziqing Xu, Guixiang Tian, Feizhen Wu, Sheng Wei & Guoying Huang
Additional file 3. Additional methods. Pathway analysis of the prioritized genes, the databases, and the dataset.

Additional file 3 of Copy number variant analysis for syndromic congenital heart disease in the Chinese population

Ping Li, Weicheng Chen, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Han Gao, Meijiao Suo, Ziqing Xu, Guixiang Tian, Feizhen Wu, Sheng Wei & Guoying Huang
Additional file 3. Additional methods. Pathway analysis of the prioritized genes, the databases, and the dataset.

Additional file 5 of Copy number variant analysis for syndromic congenital heart disease in the Chinese population

Ping Li, Weicheng Chen, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Han Gao, Meijiao Suo, Ziqing Xu, Guixiang Tian, Feizhen Wu, Sheng Wei & Guoying Huang
Additional file 5. Fig. S1. Gene ontology analysis of the 1249 candidate genes (1129 matched).

Additional file 9 of Copy number variant analysis for syndromic congenital heart disease in the Chinese population

Ping Li, Weicheng Chen, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Han Gao, Meijiao Suo, Ziqing Xu, Guixiang Tian, Feizhen Wu, Sheng Wei & Guoying Huang
Additional file 9. Fig. S2. Interaction analyses of prioritized genes by different tools.

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le & Longjia Yan
A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of the target compounds existed excellent antitumor activities. In particular, the IC50 values of compound 9u (E)-3-((2-((4-(3-(3-fluorophenyl)acrylamido)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylthiophene-2-carboxamide against A549, MCF-7, PC-3 cells and EGFR kinase reached to 0.35 μM, 3.24 μM, 5.12 μM, and 0.091 μM, respectively. Additionally, further researches...

Comparing Dose Levels to Placebo using a Continuous Outcome in a Small n, Sequential, Multiple Assignment, Randomized trial (snSMART)

Fang Fang, RoyN. Tamura, Thomas M. Braun & Kelley M. Kidwell
Identifying optimal treatments for patients living with rare diseases is challenging due to the small numbers of individuals affected. One design used to address this challenge is known as the small n, sequential, multiple assignment, randomized trial (snSMART). To investigate the efficacy of an active drug measured by a continuous outcome tested at a low and high dose compared to placebo, we propose a new two-stage snSMART design. In stage 1, patients are randomized to...

sj-docx-1-tam-10.1177_17588359221136759 – Supplemental material for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study

Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang & Caicun Zhou
Supplemental material, sj-docx-1-tam-10.1177_17588359221136759 for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study by Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang and Caicun Zhou in Therapeutic Advances in Medical Oncology

sj-docx-2-tam-10.1177_17588359221136759 – Supplemental material for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study

Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang & Caicun Zhou
Supplemental material, sj-docx-2-tam-10.1177_17588359221136759 for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study by Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang and Caicun Zhou in Therapeutic Advances in Medical Oncology

Additional file 2 of Angiotensin-converting enzyme 2 identifies immuno-hot tumors suggesting angiotensin-(1–7) as a sensitizer for chemotherapy and immunotherapy in breast cancer

Jie Mei, Yun Cai, Rui Xu, Xinqian Yu, Xu Han, Miaomiao Weng, Lingyan Chen, Tao Ma, Tianshu Gao, Fei Gao, Tiansong Xia, Yichao Zhu & Yan Zhang
Additional file 2: Table S1. Table of abbreviations in the TCGA database. Table S2. Summary of sample size of public datasets. Table S3. Detailed information of immunotherapy-related gene signatures. Table S4. Detailed information of BC patients receiving Paclitaxel-dependent neoadjuvant chemotherapy. Table S5. GO and KEGG pathway enrichment analyses of ACE2 in BC. Table S6. Association between ACE2 expression and clinic-pathological features in BC.

SUPPLEMENTAL INFORMATION from Sensory evolution in a cavefish radiation: patterns of neuromast distribution and associated behaviour in Sinocyclocheilus (Cypriniformes: Cyprinidae)

Bing Chen, Tingru Mao, Yewei Liu, Wenzhang Dai, Xianglin Li, Amrapali P. Rajput, Marcio R. Pie, Jian Yang, Joshua B. Gross & Madhava Meegaskumbura
The genus Sinocyclocheilus, comprises a large radiation of freshwater cavefishes, are well known for their presence of regressive features (e.g. variable eye reduction). Fewer constructive features are known, such as the expansion of the lateral line system (LLS), which is involved in detecting water movements. The precise relationship between LLS expansion and cave adaptation is not well understood. Here, we examine morphology and LLS-mediated behaviour in Sinocyclocheilus species characterized by broad variation in eye size,...

Additional file 6 of Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Feifei Yan, Shoumeng Yan, Jing Wang, Yani Cui, Feinan Chen, Fang Fang & Weiwei Cui
Supplementary Material 6: PRISMA 2020 Checklist

Additional file 2 of Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis

Ting Zhang, Qimin Mei, Zhaocai Zhang, Joseph Harold Walline, Yecheng Liu, Huadong Zhu & Shuyang Zhang
Additional file 2: Table S1. PRISMA checklist. Table S2. MOOSE Statement - Reporting Checklist for Authors, Editors, and Reviewers of Meta-analyses of Observational Studies.

Supplementary document for High-performance one-dimensional MOSFET array photodetectors in 0.8-μm standard CMOS process - 6056371.pdf

Yaxuan Liu, Jingye Sun, ling tong, Yuning Li & Tao Deng
supplementary materials

Additional file 1 of Bio-nanocomplexes with autonomous O2 generation efficiently inhibit triple negative breast cancer through enhanced chemo-PDT

Zhihong Zeng, Zhou Wang, Simin Chen, Chang Xiao, Minzhuo Liu, Jie Zhang, Jialong Fan, Yanzhong Zhao & Bin Liu
Additional file 1: Figure S1. A. CS-1 loading capacity and encapsulation efficiency of CPCCM NPs. B. Ce6 loading capacity and encapsulation efficiency of CPCCM NPs. Figure S2. Cell viability assay. A. Viability of 4T1 cells treated with CS-1. B. Viability of MDA-MB-231 cells treated with CS-1. The concentrations of CS-1 are 0, 1, 2.5, 5, 10, 15, and 20 μM, respectively. Figure S3. Viability of MDA-MB-231 cells treated with CS-1, Ce6, CPCC, and CPCCM with/without...

Supplemental Material - Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis

Shaowen Cheng, Rong Wang, Hengjie Zhu, Jian Yang, Jiangling Yao, Yunfu Zeng, Hongwang Cui & Binwen Huang
Supplemental Material for Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis by Shaowen Cheng, Rong Wang, Hengjie Zhu, Jian Yang, Jiangling Yao, Yunfu Zeng, Hongwang Cui and Binwen Huang in European Journal of Inflammation.

Supplemental Material - Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis

Shaowen Cheng, Rong Wang, Hengjie Zhu, Jian Yang, Jiangling Yao, Yunfu Zeng, Hongwang Cui & Binwen Huang
Supplemental Material for Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis by Shaowen Cheng, Rong Wang, Hengjie Zhu, Jian Yang, Jiangling Yao, Yunfu Zeng, Hongwang Cui and Binwen Huang in European Journal of Inflammation.

Registration Year

  • 2022
    157

Resource Types

  • Text
    157

Affiliations

  • Beijing Institute of Technology
    157
  • Nanjing Medical University
    117
  • Shanghai Jiao Tong University
    113
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    108
  • Peking University
    96
  • University of Chinese Academy of Sciences
    94
  • Huazhong University of Science and Technology
    91
  • Jilin University
    88
  • Southern Medical University
    87
  • Chinese Academy of Sciences
    87