supplementary materials

Additional file 11: Fig. S4. KEGG enrichment bubble diagram (G31 vs. G38, G38 vs. G32, G42 vs. G46). (A) and (B) showed the top 30 pathways of significant enrichment of the up-and down- regulated DEGs on KEGG for G31 vs. G38, (C) and (D) showed for G38 vs. G42, and (E) and (F) showed for G42 vs. G46.

Additional file 13: Fig. S6. Enrichment analysis of differential lipid-related DEGs. (A) showed the top 30 GO terms of significant enrichment of the differential lipid-related DEGs on GO;(B) showed the top 30 pathways of significant enrichment of the differential lipid-related DEGs on KEGG.

Additional file 9: Tables S1–S7.

Additional file 14: Fig. S7. Results of RT-qPCR.

The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showed that ND-DOX could be loaded in mouse platelets in a dose-dependent manner with a markedly higher efficiency and capacity than free DOX. ND-DOX-loaded platelets (Plt@ND-DOX) maintained viability and ND-DOX could be stably held in the platelets for at least 4...

Purpose: Oncology studies employing digital dissection methodologies have provided some insight on the biological features of tumor microenvironment of Triple-negative breast cancer (TNBC), but molecular diagnostics rarely have therapeutic impact. We aimed to identify a novel prognostic biomarker to investigate immune characteristics of TNBC using transcriptomic features. Patients and Methods: We extracted whole transcriptome from breast cancer tissue of 30 TNBC patients and then used bioinformatics approaches to characterize the different immune cell contents in...

Supplemental material, sj-docx-1-tej-10.1177_20417314221143240 for Microvessels derived from hiPSCs are a novel source for angiogenesis and tissue regeneration by Xin Gao, Shixing Ma, Xiaotao Xing, Jian Yang, Xun Xu, Cheng Liang, Yejia Yu, Lei Liu, Li Liao and Weidong Tian in Journal of Tissue Engineering

Supplemental material, sj-docx-1-tej-10.1177_20417314221143240 for Microvessels derived from hiPSCs are a novel source for angiogenesis and tissue regeneration by Xin Gao, Shixing Ma, Xiaotao Xing, Jian Yang, Xun Xu, Cheng Liang, Yejia Yu, Lei Liu, Li Liao and Weidong Tian in Journal of Tissue Engineering

Objective: To provide a detailed and differentiated description of the path to receiving the correct amyotrophic lateral sclerosis (ALS) diagnosis, including delay times, referrals, alternate diagnoses, and clinical progression. Methods: Medical records until the date of ALS diagnosis were reviewed and linked to the Swedish Motor Neuron Disease Quality Registry. Results: The study included 353 Stockholm ALS patients diagnosed in 2016–2021. Patients were divided into four groups: 117 (33.1%) with lower extremity (LE), 85 (24.1%)...

Objective: To provide a detailed and differentiated description of the path to receiving the correct amyotrophic lateral sclerosis (ALS) diagnosis, including delay times, referrals, alternate diagnoses, and clinical progression. Methods: Medical records until the date of ALS diagnosis were reviewed and linked to the Swedish Motor Neuron Disease Quality Registry. Results: The study included 353 Stockholm ALS patients diagnosed in 2016–2021. Patients were divided into four groups: 117 (33.1%) with lower extremity (LE), 85 (24.1%)...

Additional file 1: Figure S1. Pan-cancer analysis of ACE2 expression in tumor and para-tumor tissues in the TCGA database. Significance was calculated with Student’s t-test. ns-P>0.05, *P<0.05, **P<0.01, ***P<0.001, ****P < 0.0001. Figure S2. Pan-cancer analysis of the correlations between ACE2 and immunological features. (A) Correlations between ACE2 and 122 immunomodulators (chemokines, receptors, MHC and immunostimulators). The color reveals the correlation coefficient. The asterisks reveal statistical differences assessed by Pearson analysis. (B) Correlations between ACE2...

Traditional robust parameter design methods mainly focus on the optimization of quantitative quality characteristics. However, computer experiments involving qualitative and quantitative mixed input and output occur frequently in the manufacturing industry, which prompted the authors to develop an effective meta-modeling and optimization technique for such experiments. This article combines the latent variable Gaussian process (LVGP) model and fuzzy set theory to create a mixed multi-response LVGP (MMR-LVGP) model involving qualitative and quantitative mixed input and...

Additional file 1. Animal protocol.

Additional file 5. Coding Sequence of Irak1 and Traf6 Genes.

Supplemental document with details of the theoretical analysis.

Additional file 1: TableS1 Comparison of GMV volume between two groups.

Additional file 12: Fig. S5. Enrichment analysis of DEGs for B. gargarizans metamorphosis. The top 30 GO terms and pathways of significant enrichment for the (A and B) upregulated DEGs and (C and D) downregulated DEGs. The y-axis corresponds to the GO term or KEGG pathway, the x-axis corresponds to the EnrichmentScore, and the size of the point corresponds to the number of differential genes in the term or pathway.

Additional file 2: Table S1.Information on the imported isolates of P. vivax samples used in this study.

supplementary materials

Additional file 11. Fig. S3. The prioritized genes overlapping between the four tools.

Additional file 1: Table S1. The identification of phenolic components in TH.Table S2. Antioxidant capacity of candidate markers. Table S3. The in silico pharmacokinetic parametersof candidate markers. Table S4. Methodology investigation for thequantitation of four markers. Figure S1. Representative UV absorbanceprofile (a), and base peak chromatogram (b). Figure S2. PLSRmodels. The summary of fit (a-c) and permutation tests (d-f) forantioxidative activity by DPPH and FRAP, and anti-inflammatory activity,respectively. Figure S3. The toxicity of luteolin (a),...

Additional file 5. Fig. S1. Gene ontology analysis of the 1249 candidate genes (1129 matched).

Additional file 1: Fig. S1. M Molecular docking results of i) the positive-control ligand tofacitinib in the binding sites of JAK3, ii) SD-36 in the binding sites of STAT3, iii) S1P and ML056 (W146) in the binding sites of S1PR1 (A), iv) ML385 in the binding sites of Nrf2, nivolumab in the binding sites of PD-1, and v) BMS-202 in the binding sites of PD-L1 (B) with the lowest calculated binding energy conformations. In the...

Heterotopic pregnancy (HP) is a rare but potentially life-threatening event with a high risk of maternal death, which also jeopardise the coexisting intrauterine pregnancy (IUP), thus an early accurate diagnosis and prompt treatment can decrease adverse complications. We aimed to explore the early predictors for pregnancy outcomes of HP. We reviewed patients with HP following assisted reproductive technology in our institution between January 2013 and December 2020. The relationships between pregnancy outcomes and clinical features...