Additional file 1. Completed Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT) 2013 Checklist: items addressed in this clinical trial protocol.

Electrospun nanofiber membranes (ENMs) of polyvinylidene fluoride which is known as solid phase extraction materials were fabricated through electrospinning technology. Different electrospinning conditions including polymer content, spinning voltage and flow rate were investigated. The optimal operation conditions for electrospun process were set at 12% of PVDF mass fraction, 12 kV of spinning voltage, 0.5 mL h−1 of flow rate, 15 cm of receiving distance, 22 °C of spinning temperature and 45% of environmental humidity. The...

Additional file 1. Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist.

Supplemental Material, sj-pdf-1-jfi-10.1177_0192513X211041992 for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender by Jing Zhang, Tineke Fokkema and Bruno Arpino in Journal of Family Issues

Porcine epidemic diarrhea virus (PEDV) is emerging as a major threat to the global swine industry. Clinical PEDV infection is associated with severe intestinal lesions, resulting in absorptive dysfunction and high mortality rates in suckling piglets. The extracellular matrix (ECM) is an important component of intestinal tissue, providing a structural framework and conveying tissue-specific signals to nearby enterocytes. In this study, we investigated the extensive ECM remodeling observed in intestinal epithelial cells infected with PEDV...

This work studied the physical properties of three deep eutectic solvents (DESs) and their catalytic activity in the esterification of palmitic acid and ethanol. Three types of deep eutectic solvents (DESs) were successfully prepared using p-toluene sulfonic acid monohydrate (PTSA) as hydrogen bond donor (HBD) with dodecyl trimethyl ammonium chloride (DTAC), tetradecyl trimethyl ammonium chloride (TTAC) and octadecyl trimethyl ammonium chloride (OTAC) as hydrogen bond acceptor (HBA). The freezing points of DESs were measured in...

Electrospun nanofiber membranes (ENMs) of polyvinylidene fluoride which is known as solid phase extraction materials were fabricated through electrospinning technology. Different electrospinning conditions including polymer content, spinning voltage and flow rate were investigated. The optimal operation conditions for electrospun process were set at 12% of PVDF mass fraction, 12 kV of spinning voltage, 0.5 mL h−1 of flow rate, 15 cm of receiving distance, 22 °C of spinning temperature and 45% of environmental humidity. The...

A new cyclo-pentazolate anion-based energetic cocrystal NH4N5 · 1/6NH4Cl was synthesized. The structure, thermal behavior, sensitivity, and detonation properties of NH4N5 · 1/6NH4Cl were studied. Cube-shaped NH4N5 · 1/6NH4Cl crystallizes in the Fd-3 m space group, and is formed by hydrogen bonding interactions. DSC-TG-MS combined techniques show that NH4N5 · 1/6NH4Cl has better thermal stability than NH4N5. The cocrystal exhibits low impact and friction sensitivity, and largely reduces the mechanical sensitivity of NH4N5. Furthermore, the...

We studied the boundary layer effects on flame temperature measurements using line-of-sight (LOS) absorption spectroscopy. The primary objective is to quantify the measurement uncertainty of the LOS-determined temperature, which is influenced by the thermal and species boundary layers existing in standard laminar premixed flames. The boundary layer thickness (δ), central flame temperature (Tc) and species concentration (Xc) are the major factors investigated in this work. Typical absorption lines of H2O in the wavelength range of...

Six dendrobine-type alkaloids were isolated from the tubes of Dendrobium nobile by silica gel, Sephadex LH-20 gel column chromatography, and preparative HPLC. Compound 1 is a new alkaloid containing a pair of amide tautomers, whereas compound 2 is a new dendrobine-type alkaloid. By using spectroscopic techniques including 1 D and 2 D NMR, the structures of compounds 1‒6 were identified as N-methoxylcarbonyldendrobine (1), dendronboic acid (2), dendrobine (3), 6-hydroxyldendrobine (4), dendrobine N-oxide (5), and denrine...

Ribes himalense Royle ex Decne, a small shrub, is widely used as a Tibetan medicine in Chinese folk. In this study, three novel 1,1-diphenyl-2-picrylhydrazyl inhibitors named Rihimaside A, Rihimaside B, and Rihimaside C, as well as one known 1,1-diphenyl-2-picrylhydrazyl inhibitor, dihydromyricetin, were isolated from the leaves and stems of Ribes himalense Royle ex Decne using online high performance liquid chromatography-1,1-diphenyl-2-picrylhydrazyl activity screening system combined with medium and high-pressure liquid chromatography. All four 1,1-diphenyl-2-picrylhydrazyl inhibitors are...

Background: The new Family-Community-Hospital (FCH) three-level comprehensive management aimed to improve the efficiency and scale of peritoneal dialysis (PD) to meet the increased population of end-stage renal disease (ESRD). Our study focused on the clinical outcomes, quality of life, and costs evaluation of this model in a multi-center and prospective cohort study. Methods: A total of 190 ESRD patients who commenced PD at Shanghai Songjiang District were enrolled. According to different PD management models, patients...

Cancer stem cell (CSC) has been confirmed to trigger tumor occurrence and progression and CSC can develop strategies to maintain a lower reactive oxygen species (ROS) level compared to cancer cells. However, the mechanisms contributing to ROS homeostasis in CSC are still lacking key elements. In the current study, we found that reductive redox states and ROS levels were suppressed in non-adherent spheres formed by non-small cell lung cancer (NSCLC) cells, which were confirmed to...

Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-αCD NPs) and FA-modified Lut/Oxi-αCD NPs...

We studied the boundary layer effects on flame temperature measurements using line-of-sight (LOS) absorption spectroscopy. The primary objective is to quantify the measurement uncertainty of the LOS-determined temperature, which is influenced by the thermal and species boundary layers existing in standard laminar premixed flames. The boundary layer thickness (δ), central flame temperature (Tc) and species concentration (Xc) are the major factors investigated in this work. Typical absorption lines of H2O in the wavelength range of...

A new type of metal-free catalyst was successfully prepared by doping boron (B) in the carbon nanotube. The catalyst had 99.4% removal of phenol in 60 min at pH 7 by activating peroxymonosulfate (PMS). In order to explore the origin of the high catalytic activity, the samples were characterized by Raman and electron paramagnetic resonance (EPR), and the reactive oxygen species (ROS) in the process of catalytic degradation were investigated. The Raman results showed that...

Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included. The study included 56 healthy controls (males/females =26/30) and 110 first-diagnosed drug-naïve outpatients (males/females =35/75). A total of 42 patients...

A new type of metal-free catalyst was successfully prepared by doping boron (B) in the carbon nanotube. The catalyst had 99.4% removal of phenol in 60 min at pH 7 by activating peroxymonosulfate (PMS). In order to explore the origin of the high catalytic activity, the samples were characterized by Raman and electron paramagnetic resonance (EPR), and the reactive oxygen species (ROS) in the process of catalytic degradation were investigated. The Raman results showed that...

The Wanbaogou granitic plutons are exposed along with coeval volcanic rocks, and provide an opportunity to investigate Silurian tectonism in the South Kunlun belt, northwest China. This study presents new whole-rock geochemical, and zircon U–Pb geochronological and Lu–Hf isotope data for Silurian intrusive rocks of the Wanbaogou area. We analysed four samples: a porphyritic monzogranite and dioritic dike from the Wanbaogou pluton and a granodiorite and monzogranite from the Wudaogou pluton. Zircon U–Pb dating yielded...

The study aimed to systematically review the existing literature and assess the effects of percutaneous balloon mitral valvuloplasty (PBMV) in patients with mitral stenosis and atrial fibrillation (AF) as opposed to sinus rhythm (SR). Eligible studies were identified from six electronic databases before June 2021. The primary outcome was mitral valve area (MVA), and secondary outcomes were hemodynamic measurements, in-hospital complications, and long-term outcomes. Relative risks (RRs) or weighted mean differences (WMDs) with 95% confidence...

Insulin resistance (IR) is a complex pathological condition resulting from the dysregulation of cellular response to insulin hormone in insulin-dependent cells and is recognized as a pathogenic hallmark and strong risk factor for metabolic syndrome. The present study aims to elucidate the molecular mechanism of the pathogenesis of IR. Here, we used human umbilical vein endothelial cells (HUVECs) to establish the IR cell model induced by 1 × 10−6 mmol/L insulin. After 48 h, reactive...

Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of C. phaeocaulis through zebrafish and rat models. Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed C. phaeocaulis. Meanwhile,...

Capsule of alkaloids from the leaf of Alstonia scholaris (L.) R.Br. (Apocynaceae) (CALAS) is a new investigational botanical drug (No. 2011L01436) for bronchitis, post-infectious cough and asthma. To observe the clinical safety and tolerability of CALAS. Subjects were assigned to eight cohorts, and each received randomly CALAS or placebo in one of single ascending dose (SAD) of 8, 40, 120, 240, 360, 480, or in one of multiple ascending dose (MAD) of 40 or 120...

Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of C. phaeocaulis through zebrafish and rat models. Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed C. phaeocaulis. Meanwhile,...

Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-αCD NPs) and FA-modified Lut/Oxi-αCD NPs...