30 Works

Additional file 1 of Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide

Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva & Francesco Moccia
Additional file 1: Text. IP3-induced intracellular Ca2+ release and SOCE drive spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S1. Resting [Ca2+]iin C-MSC. Fig. S2. Suramin and MRS-2179 inhibit the spontaneous Ca2+ activity in ACM C-MSC. Fig. S3. CaMKII expression in human-derived C-MSC. Figure S4: SOCE and IP3Rs drive the spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S5. Effect of XeC on spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S6. Contribution of VOCC and reverse-mode NCX...

Additional file 1 of Combining denoising of RNA-seq data and flux balance analysis for cluster analysis of single cells

Bruno G. Galuzzi, Marco Vanoni & Chiara Damiani
Additional file 1. Cell-cycle effect on flux cluster analysis.

Supplemental Material, sj-pdf-1-ssc-10.1177_08944393211018969 - Smartphone Use and Academic Performance: A Pervasiveness Approach Beyond Addiction

Tiziano Gerosa, Marco Gui & Moritz Büchi
Supplemental Material, sj-pdf-1-ssc-10.1177_08944393211018969 for Smartphone Use and Academic Performance: A Pervasiveness Approach Beyond Addiction by Tiziano Gerosa, Marco Gui and Moritz Büchi in Social Science Computer Review

Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression

Letizia Squarcina, Lana Kambeitz-Ilankovic, Carolina Bonivento, Cecilia Prunas, Lucio Oldani, Julian Wenzel, Anne Ruef, Dominic Dwyer, Adele Ferro, Stefan Borgwardt, Joseph Kambeitz, Theresa Katharina Lichtenstein, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Rachel Upthegrove, Linda A. Antonucci, Alessandro Bertolino, Rebekka Lencer, Stephan Ruhrmann, Raimo R. K. Salokangas, Frauke Schultze-Lutter, Katharine Chisholm, Alexandra Stainton, Stephen J. Wood … & Paolo Brambilla
Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Additional file 3 of miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators

Elisabetta Vergani, Matteo Dugo, Mara Cossa, Simona Frigerio, Lorenza Di Guardo, Gianfrancesco Gallino, Ilaria Mattavelli, Barbara Vergani, Luca Lalli, Elena Tamborini, Barbara Valeri, Chiara Gargiuli, Eriomina Shahaj, Marina Ferrarini, Elisabetta Ferrero, Macarena Gomez Lira, Veronica Huber, Michele Del Vecchio, Marialuisa Sensi, Biagio Eugenio Leone, Mario Santinami, Licia Rivoltini, Monica Rodolfo & Viviana Vallacchi
Additional file 2: Supplementary Fig. S1. Altered miR-146a expression influences BRAF/MEKi sensitivity and apoptosis in melanoma. A) Boxplots representing IC50 values of 6 matched PLX4032-resistant (R) and sensitive (S) melanoma cell lines to PLX4032 (vemurafenib), BRAFi (dabrafenib), MEKi (trametinib), to the combined treatment BRAF/MEKi, and to sTRAIL-induced apoptosis. B) Inverse correlation between miR-146a expression levels and IC50 values of PLX4032, BRAFi and MEKi in melanoma cell lines (Spearman analysis). C) Forced expression of miR-146a (+m-miR-146a)...

Additional file 3 of miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators

Elisabetta Vergani, Matteo Dugo, Mara Cossa, Simona Frigerio, Lorenza Di Guardo, Gianfrancesco Gallino, Ilaria Mattavelli, Barbara Vergani, Luca Lalli, Elena Tamborini, Barbara Valeri, Chiara Gargiuli, Eriomina Shahaj, Marina Ferrarini, Elisabetta Ferrero, Macarena Gomez Lira, Veronica Huber, Michele Del Vecchio, Marialuisa Sensi, Biagio Eugenio Leone, Mario Santinami, Licia Rivoltini, Monica Rodolfo & Viviana Vallacchi
Additional file 2: Supplementary Fig. S1. Altered miR-146a expression influences BRAF/MEKi sensitivity and apoptosis in melanoma. A) Boxplots representing IC50 values of 6 matched PLX4032-resistant (R) and sensitive (S) melanoma cell lines to PLX4032 (vemurafenib), BRAFi (dabrafenib), MEKi (trametinib), to the combined treatment BRAF/MEKi, and to sTRAIL-induced apoptosis. B) Inverse correlation between miR-146a expression levels and IC50 values of PLX4032, BRAFi and MEKi in melanoma cell lines (Spearman analysis). C) Forced expression of miR-146a (+m-miR-146a)...

Additional file 1 of NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population

Stefano Ciardullo, Federico Rea, Rosa Cannistraci, Emanuele Muraca, Silvia Perra, Francesca Zerbini, Andrea Mortara & Gianluca Perseghin
Additional file 1: Fig. S1. Flow-chart of the studied participants. Fig. S2. Cumulative incidence of cardiovascular and non-cardiovascular mortality in the whole population and according to glucose tolerance. Table S1. Cox-proportional hazard model evaluating the association between NT-ProBNP levels and all-cause mortality according to baseline HbA1c levels by excluding patients with chronic kidney disease.

Additional file 1 of Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Simona Caruso, Biagio De Angelis, Francesca Del Bufalo, Roselia Ciccone, Samantha Donsante, Gabriele Volpe, Simona Manni, Marika Guercio, Michele Pezzella, Laura Iaffaldano, Domenico Alessandro Silvestris, Matilde Sinibaldi, Stefano Di Cecca, Angela Pitisci, Enrico Velardi, Pietro Merli, Mattia Algeri, Mariachiara Lodi, Valeria Paganelli, Marta Serafini, Mara Riminucci, Franco Locatelli & Concetta Quintarelli
Additional file 1. Supplementary Materials.

Additional file 1 of Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide

Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva & Francesco Moccia
Additional file 1: Text. IP3-induced intracellular Ca2+ release and SOCE drive spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S1. Resting [Ca2+]iin C-MSC. Fig. S2. Suramin and MRS-2179 inhibit the spontaneous Ca2+ activity in ACM C-MSC. Fig. S3. CaMKII expression in human-derived C-MSC. Figure S4: SOCE and IP3Rs drive the spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S5. Effect of XeC on spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S6. Contribution of VOCC and reverse-mode NCX...

Additional file 1 of Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery

Miklosh Bala, Fausto Catena, Jeffry Kashuk, Belinda De Simone, Carlos Augusto Gomes, Dieter Weber, Massimo Sartelli, Federico Coccolini, Yoram Kluger, Fikri M. Abu-Zidan, Edoardo Picetti, Luca Ansaloni, Goran Augustin, Walter L. Biffl, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra, Yunfeng Cui, Dimitris Damaskos, Salomone Di Saverio, Joseph M. Galante, Vladimir Khokha, Andrew W. Kirkpatrick, Kenji Inaba … & Ernest E. Moore
Additional file 1: Table S3. Summary of the updated 2022 guidelines for AMI: statements and recommendations.

A global rate of denudation from cosmogenic nuclides in the Earth’s largest rivers

Hella Wittmann , Marcus Oelze , Jerome Gaillardet , Eduardo Garzanti & Friedhelm von Blanckenburg
Cosmogenic nuclide analysis in sediment from the Earth’s largest rivers yields mean denudation rates of the sediment-producing areas that average out local variations commonly found in small rivers. Using this approach, we measured in situ cosmogenic 26Al and 10Be in sand of >50 large rivers over a range of climatic and tectonic regimes covering 32% of the Earth’s terrestrial surface. In 35% of the analyzed rivers, 26Al/10Be ratios are significantly lower than these nuclides´ surface-production-rate...

The Tangible and Intangible Heritages of Iranian Nomads: the Touristic Potential of Pastoral Nomadism

Hossein Noroozi

Additional file 1 of Combining denoising of RNA-seq data and flux balance analysis for cluster analysis of single cells

Bruno G. Galuzzi, Marco Vanoni & Chiara Damiani
Additional file 1. Cell-cycle effect on flux cluster analysis.

Transcontinental retroarc sediment routing controlled by subduction geometry and climate change (Central and Southern Andes, Argentina)

Eduardo Garzanti , Tomas Capaldi , Giovanni Vezzoli , Mara Limonta & Numa Sosa
Central Argentina from the Pampean flat-slab segment to northern Patagonia (27-41°S) represents a classic example of a broken retroarc basin with strong tectonic and climatic control on fluvial sediment transport. In this provenance study, we combine framework petrography and heavy-mineral data to trace multistep dispersal of volcaniclastic detritus first eastwards across central Argentina for up to ~1500 km and next northwards for nearly another 1000 km along the Atlantic coast. Compositional signatures reflect different tectono-stratigraphic...

Additional file 1 of Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population

Iulia Petria, Samuel Albuquerque, Gaël Varoquaux, Jill-Jênn Vie, Nicolas Venteclef, Kamel Mohammedi, Ronan Roussel, Marion Camoin, Gianluca Perseghin, Gilberto Velho & Louis Potier
Additional file 1: Table S1. Characteristics of participants at EDIC baseline by the incidence of MACE during EDIC follow-up. Table S2. Risk of outcomes in adult participants during EDIC follow-up by indices of intraindividual variability of body-weight during the DCCT. Table S3. Risk of outcomes during EDIC follow-up by indices of intraindividual variability of body-weight computed with body-weight measures from baseline to the end of DCCT follow-up. Figure S1. Flowchart of participants. Figure S2. Forest...

Plio-Quaternary kinematics and geometry of the Calama-Olacapato-El Toro fault zone across the Puna Plateau, Argentina

Claudia Corazzato, Alessandro Tibaldi, Alessandro Cavallo, FABIO LUCA BONALI, Federica Lanza & A. Nardin

Additional file 3 of miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators

Elisabetta Vergani, Matteo Dugo, Mara Cossa, Simona Frigerio, Lorenza Di Guardo, Gianfrancesco Gallino, Ilaria Mattavelli, Barbara Vergani, Luca Lalli, Elena Tamborini, Barbara Valeri, Chiara Gargiuli, Eriomina Shahaj, Marina Ferrarini, Elisabetta Ferrero, Macarena Gomez Lira, Veronica Huber, Michele Del Vecchio, Marialuisa Sensi, Biagio Eugenio Leone, Mario Santinami, Licia Rivoltini, Monica Rodolfo & Viviana Vallacchi
Additional file 2: Supplementary Fig. S1. Altered miR-146a expression influences BRAF/MEKi sensitivity and apoptosis in melanoma. A) Boxplots representing IC50 values of 6 matched PLX4032-resistant (R) and sensitive (S) melanoma cell lines to PLX4032 (vemurafenib), BRAFi (dabrafenib), MEKi (trametinib), to the combined treatment BRAF/MEKi, and to sTRAIL-induced apoptosis. B) Inverse correlation between miR-146a expression levels and IC50 values of PLX4032, BRAFi and MEKi in melanoma cell lines (Spearman analysis). C) Forced expression of miR-146a (+m-miR-146a)...

Museums and Shrines: Reflecting on Relationships and Challenges

Lorenzo Bagnoli & Rita Capurro

Supplemental Material, sj-pdf-1-ssc-10.1177_08944393211018969 - Smartphone Use and Academic Performance: A Pervasiveness Approach Beyond Addiction

Tiziano Gerosa, Marco Gui & Moritz Büchi
Supplemental Material, sj-pdf-1-ssc-10.1177_08944393211018969 for Smartphone Use and Academic Performance: A Pervasiveness Approach Beyond Addiction by Tiziano Gerosa, Marco Gui and Moritz Büchi in Social Science Computer Review

Association between hypertensive medication during pregnancy and risk of several maternal and neonatal outcomes in women with chronic hypertension: a population-based study

Anna Cantarutti, Gloria Porcu, Anna Locatelli & Giovanni Corrao
Several studies have reported an association between perinatal complications and the severity of the hypertensive disease. The increasing number of pregnancies complicated by hypertension and the small assurance about the perinatal effects of hypertensive drug use during pregnancy involves the need of studying the better management of hypertensive mothers. To evaluate the association between maternal use of antihypertensive drugs and maternal and neonatal outcomes in women with chronic hypertension. We conducted a population-based study including...

Additional file 1 of Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery

Miklosh Bala, Fausto Catena, Jeffry Kashuk, Belinda De Simone, Carlos Augusto Gomes, Dieter Weber, Massimo Sartelli, Federico Coccolini, Yoram Kluger, Fikri M. Abu-Zidan, Edoardo Picetti, Luca Ansaloni, Goran Augustin, Walter L. Biffl, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra, Yunfeng Cui, Dimitris Damaskos, Salomone Di Saverio, Joseph M. Galante, Vladimir Khokha, Andrew W. Kirkpatrick, Kenji Inaba … & Ernest E. Moore
Additional file 1: Table S3. Summary of the updated 2022 guidelines for AMI: statements and recommendations.

Additional file 1 of Increased risk of myocarditis and pericarditis and reduced likelihood of severe clinical outcomes associated with COVID-19 vaccination: a cohort study in Lombardy, Italy

Giovanni Corrao, Matteo Franchi, Danilo Cereda, Francesco Bortolan, Olivia Leoni, Eugenio Vignati, Giovanni Pavesi & Andrea Gori
Additional file 1: Table S1. Codes used for identifying cardiovascular comorbidities.

Additional file 1 of Increased risk of myocarditis and pericarditis and reduced likelihood of severe clinical outcomes associated with COVID-19 vaccination: a cohort study in Lombardy, Italy

Giovanni Corrao, Matteo Franchi, Danilo Cereda, Francesco Bortolan, Olivia Leoni, Eugenio Vignati, Giovanni Pavesi & Andrea Gori
Additional file 1: Table S1. Codes used for identifying cardiovascular comorbidities.

Additional file 1 of Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population

Iulia Petria, Samuel Albuquerque, Gaël Varoquaux, Jill-Jênn Vie, Nicolas Venteclef, Kamel Mohammedi, Ronan Roussel, Marion Camoin, Gianluca Perseghin, Gilberto Velho & Louis Potier
Additional file 1: Table S1. Characteristics of participants at EDIC baseline by the incidence of MACE during EDIC follow-up. Table S2. Risk of outcomes in adult participants during EDIC follow-up by indices of intraindividual variability of body-weight during the DCCT. Table S3. Risk of outcomes during EDIC follow-up by indices of intraindividual variability of body-weight computed with body-weight measures from baseline to the end of DCCT follow-up. Figure S1. Flowchart of participants. Figure S2. Forest...

Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression

Letizia Squarcina, Lana Kambeitz-Ilankovic, Carolina Bonivento, Cecilia Prunas, Lucio Oldani, Julian Wenzel, Anne Ruef, Dominic Dwyer, Adele Ferro, Stefan Borgwardt, Joseph Kambeitz, Theresa Katharina Lichtenstein, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Rachel Upthegrove, Linda A. Antonucci, Alessandro Bertolino, Rebekka Lencer, Stephan Ruhrmann, Raimo R. K. Salokangas, Frauke Schultze-Lutter, Katharine Chisholm, Alexandra Stainton, Stephen J. Wood … & Paolo Brambilla
Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Registration Year

  • 2022
    23
  • 2021
    3
  • 2020
    2
  • 2010
    2

Resource Types

  • Text
    30

Affiliations

  • University of Milano-Bicocca
    30
  • University of Milan
    8
  • University of Pavia
    4
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
    4
  • University of Paris
    4
  • Institut Necker Enfants Malades
    2
  • University of Padua
    2
  • Massachusetts General Hospital
    2
  • Centro Cardiologico Monzino
    2
  • Edinburgh Royal Infirmary
    2