Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Additional file 1. Cell-cycle effect on flux cluster analysis.

Additional file 1: Text. IP3-induced intracellular Ca2+ release and SOCE drive spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S1. Resting [Ca2+]iin C-MSC. Fig. S2. Suramin and MRS-2179 inhibit the spontaneous Ca2+ activity in ACM C-MSC. Fig. S3. CaMKII expression in human-derived C-MSC. Figure S4: SOCE and IP3Rs drive the spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S5. Effect of XeC on spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S6. Contribution of VOCC and reverse-mode NCX...

Cosmogenic nuclide analysis in sediment from the Earth’s largest rivers yields mean denudation rates of the sediment-producing areas that average out local variations commonly found in small rivers. Using this approach, we measured in situ cosmogenic 26Al and 10Be in sand of >50 large rivers over a range of climatic and tectonic regimes covering 32% of the Earth’s terrestrial surface. In 35% of the analyzed rivers, 26Al/10Be ratios are significantly lower than these nuclides´ surface-production-rate...

Central Argentina from the Pampean flat-slab segment to northern Patagonia (27-41°S) represents a classic example of a broken retroarc basin with strong tectonic and climatic control on fluvial sediment transport. In this provenance study, we combine framework petrography and heavy-mineral data to trace multistep dispersal of volcaniclastic detritus first eastwards across central Argentina for up to ~1500 km and next northwards for nearly another 1000 km along the Atlantic coast. Compositional signatures reflect different tectono-stratigraphic...

Additional file 1: Table S3. Summary of the updated 2022 guidelines for AMI: statements and recommendations.

Additional file 1. Cell-cycle effect on flux cluster analysis.

Additional file 1: Table S1. Characteristics of participants at EDIC baseline by the incidence of MACE during EDIC follow-up. Table S2. Risk of outcomes in adult participants during EDIC follow-up by indices of intraindividual variability of body-weight during the DCCT. Table S3. Risk of outcomes during EDIC follow-up by indices of intraindividual variability of body-weight computed with body-weight measures from baseline to the end of DCCT follow-up. Figure S1. Flowchart of participants. Figure S2. Forest...

Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Several studies have reported an association between perinatal complications and the severity of the hypertensive disease. The increasing number of pregnancies complicated by hypertension and the small assurance about the perinatal effects of hypertensive drug use during pregnancy involves the need of studying the better management of hypertensive mothers. To evaluate the association between maternal use of antihypertensive drugs and maternal and neonatal outcomes in women with chronic hypertension. We conducted a population-based study including...

Additional file 1: Table S1. Codes used for identifying cardiovascular comorbidities.

Additional file 1: Table S1. Codes used for identifying cardiovascular comorbidities.

Additional file 1: Table S1. Characteristics of participants at EDIC baseline by the incidence of MACE during EDIC follow-up. Table S2. Risk of outcomes in adult participants during EDIC follow-up by indices of intraindividual variability of body-weight during the DCCT. Table S3. Risk of outcomes during EDIC follow-up by indices of intraindividual variability of body-weight computed with body-weight measures from baseline to the end of DCCT follow-up. Figure S1. Flowchart of participants. Figure S2. Forest...

Additional file 1: Table S3. Summary of the updated 2022 guidelines for AMI: statements and recommendations.

Additional file 2: Supplementary Fig. S1. Altered miR-146a expression influences BRAF/MEKi sensitivity and apoptosis in melanoma. A) Boxplots representing IC50 values of 6 matched PLX4032-resistant (R) and sensitive (S) melanoma cell lines to PLX4032 (vemurafenib), BRAFi (dabrafenib), MEKi (trametinib), to the combined treatment BRAF/MEKi, and to sTRAIL-induced apoptosis. B) Inverse correlation between miR-146a expression levels and IC50 values of PLX4032, BRAFi and MEKi in melanoma cell lines (Spearman analysis). C) Forced expression of miR-146a (+m-miR-146a)...

Additional file 1. Supplementary Materials.

Additional file 1: Fig. S1. Flow-chart of the studied participants. Fig. S2. Cumulative incidence of cardiovascular and non-cardiovascular mortality in the whole population and according to glucose tolerance. Table S1. Cox-proportional hazard model evaluating the association between NT-ProBNP levels and all-cause mortality according to baseline HbA1c levels by excluding patients with chronic kidney disease.

Additional file 1: Text. IP3-induced intracellular Ca2+ release and SOCE drive spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S1. Resting [Ca2+]iin C-MSC. Fig. S2. Suramin and MRS-2179 inhibit the spontaneous Ca2+ activity in ACM C-MSC. Fig. S3. CaMKII expression in human-derived C-MSC. Figure S4: SOCE and IP3Rs drive the spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S5. Effect of XeC on spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S6. Contribution of VOCC and reverse-mode NCX...

Supplemental material, sj-docx-1-sjp-10.1177_14034948221141807 for Nordic paradox in action: The complicated relation between social mobility and health inequalities in an international comparative study by David Consolazio, Simone Sarti and Marco Terraneo in Scandinavian Journal of Public Health

The Zambezi River rises at the center of southern Africa, flows across the low-relief Kalahari Plateau, meets Karoo basalt, plunges into Victoria Falls, follows along Karoo rifts, and pierces through Precambrian basement to eventually deliver its load onto the Mozambican passive margin. The river is subdivided into segments with different geological and geomorphological character, a subdivision fixed by man’s construction of large reservoirs and testified by sharp changes in sediment composition. Pure quartzose sand recycled...

Several studies have reported an association between perinatal complications and the severity of the hypertensive disease. The increasing number of pregnancies complicated by hypertension and the small assurance about the perinatal effects of hypertensive drug use during pregnancy involves the need of studying the better management of hypertensive mothers. To evaluate the association between maternal use of antihypertensive drugs and maternal and neonatal outcomes in women with chronic hypertension. We conducted a population-based study including...

Additional file 1. Supplementary Materials.

Additional file 1: Fig. S1. Flow-chart of the studied participants. Fig. S2. Cumulative incidence of cardiovascular and non-cardiovascular mortality in the whole population and according to glucose tolerance. Table S1. Cox-proportional hazard model evaluating the association between NT-ProBNP levels and all-cause mortality according to baseline HbA1c levels by excluding patients with chronic kidney disease.

Supplemental material, sj-docx-1-sjp-10.1177_14034948221141807 for Nordic paradox in action: The complicated relation between social mobility and health inequalities in an international comparative study by David Consolazio, Simone Sarti and Marco Terraneo in Scandinavian Journal of Public Health