2,234 Works

Supplemental Material - Relationship Between Atherogenic Index of Plasma and Serum Uric Acid in Patients With Untreated Essential Hypertension in China: A Cross-Sectional Study

Xiaoxiang Ma, Xin Zhang, Yanhua Yang, Li Jiang & Zhaoyi Huang
Supplemental Material for Relationship Between Atherogenic Index of Plasma and Serum Uric Acid in Patients With Untreated Essential Hypertension in China: A Cross-Sectional Study by Xiaoxiang Ma, MD, PhD, Xin Zhang, MD, PhD, Yanhua Yang, MSc, Li Jiang, BSc, and Zhaoyi Huang, BSc in Angiology

Additional file 2 of Global, regional, and national burden of cirrhosis and other chronic liver diseases due to alcohol use, 1990–2019: a systematic analysis for the Global Burden of Disease study 2019

Xiansheng Zhang, Xin Zhang, Meilian Liu, Lin Zhu & Zhuokai He
Additional file 2. Supplementary tables.

Supplementary document for Effects of optical aberrations on localization of MINFLUX super-resolution microscopy - 6151527.pdf

Chenying He, Zhengyi Zhan, Chuankang Li, Xiaofan Sun, Yong Liu, Cuifang Kuang & Xu Liu
Supplement 1

Supplementary document for High-harmonic generation in polycrystalline CdTe nano-films via macroscopic investigations - 6191046.pdf

Hang Yang, Zhe Long, Kan Tian, Sen Lin, Linzhen He, Dewei Zhao, Yang Li, Han Wu, Ziyu Chen & Lili Wu
Supplemental information

A General Framework for Identifying Hierarchical Interactions and Its Application to Genomics Data

Xiao Zhang, Xingjie Shi, Yiming Liu, Xu Liu & Shuangge Ma
The analysis of hierarchical interactions has long been a challenging problem due to the large number of candidate main effects and interaction effects, and the need for accommodating the “main effects, interactions” hierarchy. The two-stage analysis methods enjoy simplicity and low computational cost, but contradict the fact that the outcome of interest is attributable to the joint effects of multiple main factors and their interactions. The existing joint analysis methods can accurately describe the underlying...

sj-docx-1-asm-10.1177_10731911221137540 – Supplemental material for Self-Compassion in Chinese Young Adults: Its Measurement and Measurement Construct

Mengya Zhao, Tamsin Ford, Janet Smithson, Peng Wang & Anke Karl
Supplemental material, sj-docx-1-asm-10.1177_10731911221137540 for Self-Compassion in Chinese Young Adults: Its Measurement and Measurement Construct by Mengya Zhao, Tamsin Ford, Janet Smithson, Peng Wang and Anke Karl in Assessment

Non-invasive fetal sex determination by maternal plasma sequencing and application in X-linked disorder counseling

Xiaoyu Pan, Chunlei Zhang, Xuchao Li, Shengpei Chen, Huijuan Ge, Yanyan Zhang, Fang Chen, Hui Jiang, Fuman Jiang, Hongyun Zhang, Wei Wang & Xiuqing Zhang
Objective: To develop a fetal sex determination method based on maternal plasma sequencing (MPS), assess its performance and potential use in X-linked disorder counseling. Methods: 900 cases of MPS data from a previous study were reviewed, in which 100 and 800 cases were used as training and validation set, respectively. The percentage of uniquely mapped sequencing reads on Y chromosome was calculated and used to classify male and female cases. Eight pregnant women who are...

sj-docx-1-tan-10.1177_17562864221138148 – Supplemental material for Vigabatrin-associated brain abnormalities on MRI in tuberous sclerosis complex patients with infantile spasms: are they preventable?

Lin Wan, Wen He, Yang-Yang Wang, Yong Xu, Qian Lu, Meng-Na Zhang, Qiu-Hong Wang, Shuo Dun, Li-Ying Liu, Xiu-Yu Shi, Jing Wang, Lin-Yan Hu, Bo Zhang, Guang Yang & Li-Ping Zou
Supplemental material, sj-docx-1-tan-10.1177_17562864221138148 for Vigabatrin-associated brain abnormalities on MRI in tuberous sclerosis complex patients with infantile spasms: are they preventable? by Lin Wan, Wen He, Yang-Yang Wang, Yong Xu, Qian Lu, Meng-Na Zhang, Qiu-Hong Wang, Shuo Dun, Li-Ying Liu, Xiu-Yu Shi, Jing Wang, Lin-Yan Hu, Bo Zhang, Guang Yang and Li-Ping Zou in Therapeutic Advances in Neurological Disorders

Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway

Wei-Wei Ye, Xiang-Ying Meng, Qian Zhao, Jian-Yang Chen, Cong Liu, Feng Chen, Yong Zhou & Yi Wang
Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO2 cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.

Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway

Wei-Wei Ye, Xiang-Ying Meng, Qian Zhao, Jian-Yang Chen, Cong Liu, Feng Chen, Yong Zhou & Yi Wang
Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO2 cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.

Two new triterpenes isolated from Maytenus guangxiensis C. Y. Cheng et W. L. Sha and their antiproliferative activities

YuanYuan Huang, Lu Chen, Jing Yao, XueGong Jia, FuSheng Deng, JingYa Mo & JingQuan Yuan
Two new triterpenes, 3β, 7β-dihydroxyolean-12-en-11-one (1) and 3β-O-acetyl-7β-hydroxyolean-12-en-11-one (2), along with four known triterpenes 3β-hydroxyolean-12-en-11-one (3), β-amyrin (4), lup-20(29)-ene-1β, 3β-diol (5) and 1β, 3β-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems and leaves of Maytenus guangxiensis C. Y. Cheng et W. L. Sha. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and IR experiments. Compounds (3-6) were isolated from M. guangxiensis for the first time. Compounds 1–6 were evaluated for...

Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis

Qian Liu, Zhen Liu, Chen-Chen Wang, Xin Gao, Chuan-Bao Li, Meng Wang, Qiang Wang & Jian-Ping Cai
Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the accurate diagnosis of osteoporosis and better health care for prevention. This study aimed to investigate the efficacy of oxidative stress markers—8-oxo-7,8-dihydroguanine (8-oxoGsn) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) in the assessment of osteoporosis. We conducted a cross-sectional study among menopausal women with a mean...

Drying strain behavior of elm earlywood and latewood with digital image correlation method

Jia Liu, Wenjing Liu, Rui Tan, Weiming Huang, Bin Wang, Shuai Zhang & Minghui Zhang
The strain variations in Elm earlywood and latewood during drying were studied with digital image correlation method. Also, the moisture contents of different water states were quantified based on time-domain nuclear magnetic resonance technique to reveal the strain-water relationships. Although the shrinkage strains gradually increased with increasing drying time, there was a significant difference in the strain distribution of the earlywood and latewood. Owing to latewood large stress, the earlywood was pulled by it to...

Genome-Scale CRISPR Screen Identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma

Jiaomeng Pan, Mao Zhang, Liangqing Dong, Shuyi Ji, Juan Zhang, Shu Zhang, Youpei Lin, Xiaoying Wang, Zhenbin Ding, Shuangjian Qiu, Daming Gao, Jian Zhou, Jia Fan & Qiang Gao
Drug resistance has greatly limited the clinical efficacy of lenvatinib in hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms of lenvatinib resistance remain largely undetermined. Further in-depth exploration of mechanisms underlying lenvatinib resistance is still required for the majority of HCC patients. In this study, integrated unbiased whole-genome CRISPR-Cas9 screen with database analysis indicated LAPTM5 (lysosomal protein transmembrane 5) as the critical contributor to lenvatinib resistance in HCC. We revealed that LAPTM5 could promote intrinsic...

Factors influencing magnetic resonance imaging finding of endopelvic fascial edema after ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids

Yuhang Liu, Yang Liu, Fajin Lv, Yuqing Zhong, Zhibo Xiao & Furong Lv
Investigate the relationships between endopelvic fascial edema and its influencing factors after ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroids. This retrospective study included 688 women with uterine fibroids treated by USgHIFU; based on post-treatment MRI, the patients were divided into two groups: endopelvic fascial edema group and nonedema group. The specific location of fascial edema of each patient was also recorded. Fascial edema and fibroid features and treatment parameters were set as the...

Additional file 1 of Predictive worth of estimated glucose disposal rate: evaluation in patients with non-ST-segment elevation acute coronary syndrome and non-diabetic patients after percutaneous coronary intervention

Chi Liu, Xiaoli Liu, Xiaoteng Ma, Yujing Cheng, Yan Sun, Dai Zhang, Qi Zhao & Yujie Zhou
Additional file 1: Table S1. Unadjusted Cox regression analysis investigating predictors of MACCE. Figure S1. Calculation of Gensini score of representative case.

Additional file 4 of Identification and expression analysis of BURP domain-containing genes in jujube and their involvement in low temperature and drought response

Wenzhu Wang, Zhong Zhang & Xingang Li
Additional file 4: Fig S3. The original, uncropped gel of RT-PCR analysis of ZjBURPs in three tissues. The red box denoted the region of the original gel. The bands in the F, YF, and L row represented ZjBURPs expression in flower, young fruit, and leaf, respectively. 1-9: ZjBNM1, 2, 3, 4, 5, 6, 7, 8, and 9; 10-14: ZjBURP1, 2, 3, 4, and 5; 15-17: ZjPG1, 2, and 3; 18: Zj26S-2.

Additional file 1 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 1: Table S1. Bacterial strains used in this study.

Additional file 3 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 3: Table S3. Oligonucleotides used in this study.

Diverse early diagenetic processes of ferromanganese nodules from the eastern Pacific Ocean: evidence from mineralogy and in-situ geochemistry

Rong Su, Fengyue Sun, Xiaohu Li, Fengyou Chu, Guosheng Sun, Jie Li, Hao Wang, Zhenggang Li, Cong Zhang, Weiyan Zhang, Xiaohan Gong & Yanhui Dong
Ferromanganese nodules are a potential energy resource because of their high contents of economically interesting elements (i.e. Mn, Ni, Cu, and Zn). These are higher in diagenetic layers than in hydrogenetic layers. The study of the causes of elemental accumulation in the diagenetic layer is useful for the exploration metal-rich nodules. A diagenetic-dominant ferromanganese nodule, from the central Clarion–Clipperton Fracture Zone of the eastern Pacific Ocean was studied from core to rim. It was divided...

Additional file 1 of AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Additional file 1.

Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

Yang Liu, Xiaoruo Zhu, Shiliang Ji, Zhen Huang, Yuhui Zang, Ying Ding, Junfeng Zhang & Zhi Ding
Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col via the transdermal route. We studied the preparation, mechanical properties, skin insertion, skin irritation, drug content, and transdermal release of the Col-loaded MN. The pharmacokinetics of Col after Col-loaded MN application were compared with...

Simulation of urban land expansion in China at 30 m resolution through 2050 under shared socioeconomic pathways

Haoming Zhuang, Guangzhao Chen, Yuchao Yan, Bingjie Li, Li Zeng, Jinpei Ou, Kangyao Liu & Xiaoping Liu
Rapid urbanization has profoundly impacted social and environmental systems. China is the world’s largest developing country. Projecting future urban expansion in China is critical to alleviate any adverse impacts and achieve sustainable development goals. However, the existing national-scale urban expansion simulations at low or medium resolutions produce significant distortions in urban spatial patterns, limiting the utility of future projections. High-resolution simulation of urban expansion is challenging on a large scale owing to high computational demands....

KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer

Xudong Dai, Yong Chen, Ning Chen, Jin Dou, Haiwen Zhuang, Jian Wang, Xin Zhao, Xiaoyu Zhang & Haijian Zhao
Resistance to chemotherapeutic drugs limits the control of gastric cancer (GC) development. The study intended to probe into the mechanism of aquaporin 3 (AQP3) on the chemoresistance of GC. Cisplatin (CDDP)-resistant cells were constructed. Parental AGS and HGC-27 cells and their respective CDDP-resistant cells were transfected with AQP3 overexpression plasmid, AQP3 short hairpin RNA (sh-AQP3) and sh-Kruppel-like factor 5 (shKLF5). The expressions of AQP3 and factors related to autophagy (LC3 I, LC3 II, Atg5, Beclin-1,...

Novel hybrid molecules based on disulfides and 1,2,4-triazole as antiproliferative agents

Junjie Li, Yang Liu, Yanle Men, Zijian Li, Yanping Shi, Xuguang Liu & Baoquan Chen
A series of novel hybrid molecules based on disulfides and 1,2,4-triazole were synthesized, and the structures of the resulting compounds (7a–7g, 8a–8g and 9a–9g) were confirmed by their IR, 1H NMR, 13C NMR and HR-ESI-MS spectroscopic data. The in vitro antiproliferative activity of the tested compounds on human cancer cells A549, Hela, SMMC-7721, and normal cells L929 was determined by CCK-8 assay. The obtained data revealed that most of the tested compounds showed some degrees...

Registration Year

  • 2022
    2,234

Resource Types

  • Text
    2,234

Affiliations

  • Shandong University
    2,234
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    1,518
  • Shanghai Jiao Tong University
    1,452
  • Sichuan University
    1,279
  • Fudan University
    1,273
  • Zhejiang University
    1,233
  • Sun Yat-sen University
    1,220
  • Huazhong University of Science and Technology
    1,153
  • Chinese Academy of Sciences
    1,152
  • Capital Medical University
    1,107