Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Aim: To investigate whether the World Health Organization Disability Assessment Schedule 2.0 (WHODAS) can provide interval level measurement of disability in Amyotrophic Lateral Sclerosis (ALS), allowing parametric analyses. Methods: Data on the WHODAS 12, 32, and 36-item versions, from 1120 patients studied at one or more time points, were fit to the Rasch model and comparisons made against ALSFRS-R, King’s staging, and mortality. Trajectory modeling was undertaken for a newly diagnosed (≤6 months) cohort of...

Additional file 3: Protein correlation heatmaps.

Additional file 4: Protein clusters.

Additional file 5: Inferred protein levels over time.

Additional file 1: List of immunity-related proteins measured.

Additional file 1: Figure S1. Stability of nanovesicles in PBS and PBS with 20% of fetal bovine serum (FBS). Nanovesicle sizes were measured using dynamic light scattering (n=3 per group). Results are presented as mean ± SD. Figure S2. The promotion of PLP-RvD1 treated macrophages to angiogenesis. (A) Capillary tube formation and (B) cell migration of HUVECs after cocultured with PBS, LP-RvD1 or PLP-RvD1 treated BMDMs. HUVECs cultured under normoxia were set as controls. Scalar...

Supplemental material, sj-docx-1-jop-10.1177_02698811221132537 for Clinical correlates of early onset antipsychotic treatment resistance by Daniela Fonseca de Freitas, Deborah Agbedjro, Giouliana Kadra-Scalzo, Emma Francis, Isobel Ridler, Megan Pritchard, Hitesh Shetty, Aviv Segev, Cecilia Casetta, Sophie E. Smart, Anna Morris, Johnny Downs, Søren Rahn Christensen, Nikolaj Bak, Bruce J. Kinon, Daniel Stahl, Richard D. Hayes and James H. MacCabe in Journal of Psychopharmacology

Additional file 2. Patient-Public Research Partner Survey.

Additional file 3. GRIPP2-LF.

Additional file 1: Appendix A. SPARC collaborators. Appendix B. Table 1 - Details of the 17 hospital sites in the United Kingdom involved in the study. Appendix C. Data Collection Form (questions included on software Enketo [18]).

Additional file 1: Figure S1. (A) Representative images of dissected tumors across the different treatment groups. (B-C) PCNA protein expression levels were selected as indices of tumor tissue proliferation for immunohistochemical detection and analysis. (D-E) TUNEL experiment of tumor tissues in different treatment groups. Figure S2. Hematoxylin and eosin staining tests (Figure S2A) and serum biochemical indices, including albumin, alanine aminotransferase, creatinine, and urea levels,(Figure S2B-E) showed that there was no significant histological evidence of...

Additional file 1: Table 1. Overall ranking for all clinics (n=26).

Additional file 1. Plain Language Summary.

The Covid-19 pandemic necessitated Emergency Remote Teaching (ERT): the sudden move of educational materials online. While ERT served its purpose, medical teachers are now faced with the long-term and complex demands of formal online teaching. One of these demands is ethical online teaching. Although ethical teaching is practiced in face-to-face situations, online teaching has new ethical issues that must be accommodated, and medical teachers who wish to teach online must be aware of these and...

Additional file 1. Supplementary Checklist 1; Supplementary Table 1: Quality assessment for quantitative studies based on the AHRQ (Agency for Healthcare Research and Quality) checklist ; Supplementary Table 2: Quality assessment for qualitative studies based on the CASP (Qualitative Research Checklist, adapted from Horntvedt et al. [15]); Supplementary Box 1: Search strategies ; Supplementary Box 2: Excluded studies with reasons; Supplementary Table 3: Factors and correlations with conspiracy theories and beliefs per study

Additional file 3: Online survey.

Additional file 4: Overview of participants in the qualitative study.

Supplementary Material 1: Patient characteristics associated with prognosis following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants

Additional file 1.

Additional file 1. Supplementary appendix. Table S1. Oligonucleotide primers used in this study. Table S2. Hospital course and outcomes by renal recovery. Risk reclassification using miR556-3p and clinical predictors compared with clinical predictors alone. Figure S1. The area under the curve (AUC) for prediction of renal recovery. Figure S2. Study design in virtual abstract.

Supplementary Material 1

Supplementary Material 1

Additional file 1: Appendix A. SPARC collaborators. Appendix B. Table 1 - Details of the 17 hospital sites in the United Kingdom involved in the study. Appendix C. Data Collection Form (questions included on software Enketo [18]).

Supplemental material, sj-pdf-1-pmj-10.1177_02692163221143153 for Palliative care for people who use drugs during communicable disease epidemics and pandemics: A scoping review on access, policies, and programs and guidelines by Daniel Z Buchman, Samantha Lo, Philip Ding, Naheed Dosani, Rouhi Fazelzad, Andrea D Furlan, Sarina R Isenberg, Sheryl Spithoff, Alissa Tedesco, Camilla Zimmerman and Jenny Lau in Palliative Medicine