Additional file 2: Supplemental Table 2. The kappa coefficients of categorical variables between three radiologists.

Some individuals with acute pancreatitis (AP) suffer from pancreatic necrosis. Diabetes affects the severity of AP, but whether diabetes influences pancreatic necrosis is unclear. This study aims to investigate the clinical characteristics of AP patients with and without diabetes as well as analyze the risk factors of pancreatic necrosis. A total of 625 AP patients participated in the study. Clinical and laboratory data were retrieved. Multivariate logistic regression analysis was used to identify the risk...

The demonstration of batch-to-batch consistency is indispensable for quality control of vaccines. We conducted a randomized, double-blind, parallel-controlled trial to evaluate the immunogenicity consistency of a single shot of Ad5-nCoV in healthy adults who had not previously received any COVID-19 vaccine. All eligible participants were randomly assigned equally to receive one of the three consecutive batches of Ad5-nCoV (5 × 1010 viral particles/vial, 0.5 mL). The primary endpoint was geometric mean titers (GMTs) of serum...

The potential for effector functions of therapeutic antibodies, including antibody-dependent cell-mediated cytotoxicity (ADCC), is a biological activity of interest for characterization, regardless of if ADCC is an intended primary pharmacological effect. The composition of the conserved antibody Fc glycan can vary as a function of post-translational processing which may affect the binding affinity to Fc receptors, leading to a change of effector activity. Ordesekimab (AMG 714 or PRV-015), a fully human immunoglobulin G1-kappa anti-interleukin (IL)-15...

The reduction of CO2 into valuable chemicals through electrocatalytic techniques provides a potential strategy to alleviate energy crises and environmental pollution. In this study, 2D M3(THT)2 (M = Fe, Co, Ni, Ru, Rh, Pd, THT = 2,3,6,7,10,11-triphenylenehexathiolate) framework as CO2 reduction reaction (CO2RR) electrocatalysts was investigated by using the density functional method. The results showed that the studied catalysts are stable both thermodynamically and electrochemically. Rh3(THT)2 exhibits the best catalytic performance to produce CH4 with...

Chronic stress is a well-established risk factor for cardiometabolic disease. Caregiving for individuals with cancer is perceived as a chronic stressor yet research on the risk for cardiometabolic disease in this population, opposed to the elderly and those with Alzheimer’s disease, is limited. Additionally, few studies have explored the early physiological changes that occur in family caregivers suggesting an elevated risk for illness. This cross-sectional study was designed to examine levels of cardiometabolic risk biomarkers...

Additional file 1. Original images for western blot.

Additional file 2.

Supplementary Material containing S1, S2 and S3.

Additional file 1: Supplement Table 1. Baseline comparison of patients and healthy donors.

Additional file 2: Supplement Table 2. Events happened in IST-R and IST-NR group.

Here, we report significant pressure-modulate optoelectronic properties of NiPS3. Upon compression, NiPS3 exhibited a photocurrent increase of five orders of magnitude over the initial value. Interestingly, when NiPS3 was finally decompressed to ambient conditions, the photocurrent could maintain a two-order-of-magnitude enhancement. In addition, the spectral response range was extended to the near-infrared spectral range (up to 1650 nm) under high pressure. Raman and XRD measurements and theoretical calculations revealed significant enhancement in both interlayer and...

Phosphorus (P) as an essential nutrient for life sustains the productivity of food systems; yet misdirected P often accumulates in wastewater and triggers water eutrophication if not properly treated. Although technologies have been developed to remove P, little attention has been paid to the recovery of P from wastewater. This work provides a comprehensive review of the state-of-the-art P removal technologies in the science of wastewater treatment. Our analyses focus on the mechanisms, removal efficiencies,...

Supplemental material, sj-pdf-1-imr-10.1177_03000605221126378 for Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases by Lei Liu, Zhouqin Lin, Ruijie Wang, Fusui Xie, Jingran Zhou, Tingting Liu, Shizhe Liu, Cailei Zhao and Bei Xia in Journal of International Medical Research

Supplemental material, sj-pdf-1-imr-10.1177_03000605221126378 for Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases by Lei Liu, Zhouqin Lin, Ruijie Wang, Fusui Xie, Jingran Zhou, Tingting Liu, Shizhe Liu, Cailei Zhao and Bei Xia in Journal of International Medical Research

Additional file 1: Table S1. Search strategy of journal publications on HTA of selected medical devices. Table S2. Search strategy of journal publications on discussing HTA of medical devices. Figure S1. PRISMA flowchart of literature review of journal publications on discussing HTA of medical devices.

Nitric oxide (NO) is involved not only in the regulation of plant growth, development, and stress responses but also in the regulation of plant-microbe interactions. Here, we demonstrate that Piriformospora indica can induce tobacco nitrate reductase to produce a NO signal in roots which enhances nitrogen uptake capacity by inducing the expression of ammonium and nitrate transporter genes and the development of lateral root and root hair, thereby promoting tobacco growth. In addition, the NO...

Supplementary

Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the accurate diagnosis of osteoporosis and better health care for prevention. This study aimed to investigate the efficacy of oxidative stress markers—8-oxo-7,8-dihydroguanine (8-oxoGsn) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) in the assessment of osteoporosis. We conducted a cross-sectional study among menopausal women with a mean...

Supplementary

Objectives: The aim of this study was to access the efficacy of probiotics combined with metformin on improvement of menstrual and metabolic patterns in women with polycystic ovary syndrome (PCOS). Methods: In this single-centre, controlled, randomized clinical trial (NCT03336840), 60 non-obese women with PCOS were randomly assigned (1:1:1) to receive probiotics (4 g daily), metformin (1.5 g daily) or their combination for 12 weeks. The primary outcome was the improvement of menstrual patterns. The secondary...

Additional file 1: Figure A1. The receiver operating characteristics (ROC) curve of SII for POD. Table A1. Association between SII as continuous variable and POD in different models. Table A2. Association between SII as categories variables used quartiles and POD in different models. Table A3. Association between SII as categories variables with a cut-off value of 650 and POD in different models. Table A4. Univariate logistic regression analyses for POD in the Model PSM.

Propagule pressure (i.e., the number of propagules) has long been recognized to play an essential role in plant invasion. But it is not clear whether propagule pressure influences the invasion of exotic plants into native plant communities when different frequencies of nitrogen are added. We established an experiment with three plant communities that included native plant communities alone (four grasses, two legumes and two forbs) or native plant communities with one or five invasive plants,...

CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disease-associated CLEC16A variant lacks a C-terminal intrinsically disordered protein region (IDPR) that is critical for mitochondrial quality control. IDPRs comprise nearly half of the human proteome, yet their mechanistic roles in human disease are poorly understood. Using carbon detect...

Additional file 1. Supplementary Material for a Successful Hybrid Deep Learning Model aiming at Promoter Identification.