Supplementary Material 1

Supplemental material, sj-docx-1-tam-10.1177_17588359221133546 for Circulating tumour DNA biomarkers in savolitinib-treated patients with non-small cell lung cancer harbouring MET exon 14 skipping alterations: a post hoc analysis of a pivotal phase 2 study by Yongfeng Yu, Yongxin Ren, Jian Fang, Lejie Cao, Zongan Liang, Qisen Guo, Sen Han, Zimei Ji, Ye Wang, Yulan Sun, Yuan Chen, Xingya Li, Hua Xu, Jianying Zhou, Liyan Jiang, Ying Cheng, Zhigang Han, Jianhua Shi, Gongyan Chen, Rui Ma, Yun Fan,...

Polycyclic aromatic hydrocarbon (PAH) contaminated agricultural soil is widespread globally. To develop a cost-effective remediation technique to effectively degrade PAH contaminated agricultural soil without disturbing crop production, an in-situ co-remediation of PAH contaminated agricultural soil using blood meal and celery was assessed in an agricultural greenhouse. Results showed PAH dissipation rates increased significantly in agricultural soil when co-remediated by blood meal and celery. Planting celery and addition of 5 g•kg−1 blood meal removed 53.13% of...

Ecological quality assessment is fundamental to revealing changes in ecological environments before the development of effective ecological conservation policies. The complex ecological environment can be assessed more reliably when multiple remote sensing indices are integrated, such as in the use of the prevalent Remote Sensing-based Ecological Index (RSEI). However, for effective ecological quality assessment, the requirement of acquisition time consistency for images has become an outstanding issue for broadening the application of the RSEI. In...

Additional file 1: FigureS1. The receiver operating characteristic (ROC) curves of DEG expression in differentiating the malaria-infected group from the noninfected group in discovery cohorts GSE117613, GSE1124-GPL96, and GSE34404 and validation cohort GSE35858.

Additional file 1: Table S1. Instrumental variables used in MR analysis of the association between gut microbiota and PE. Table S2. Full result of MR estimates for the association between gut microbiota and PE. Table S3. The heterogeneity of gut microbiota instrumental variables. Table S4. Directional horizontal pleiotropy assessed by intercept term in MR Egger regression of the association between gut microbiota and PE. Table S5. MR-PRESSO analysis for the association between gut microbiota and...

Additional file 6: FigureS6. Immunophenotyping of whole-blood samples in malaria-infected and uninfected groups in GSE1124 datasets based on ssGSEA. The ssGSEA scores (enrichment level) were compared between noninfected and malaria-infected groups in each dataset. The statistical analyses were performed using the unpaired t-test. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.

Additional file 6: FigureS6. Immunophenotyping of whole-blood samples in malaria-infected and uninfected groups in GSE1124 datasets based on ssGSEA. The ssGSEA scores (enrichment level) were compared between noninfected and malaria-infected groups in each dataset. The statistical analyses were performed using the unpaired t-test. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.

Additional file 7: Figure S7. Immunophenotyping of whole-blood samples in malaria-infected and uninfected groups in GSE117613 datasets based on ssGSEA. The ssGSEA scores (enrichment level) were compared between noninfected and malaria-infected groups in each dataset. The statistical analyses were performed using the unpaired t-test. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.

Appendix Tables and Figures supporting our foudings.

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221146128 for A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization by Baoshan Qiu, Zichen Zhao, Nan Wang, Ziyan Feng, Xing-jun Chen, Weiqi Chen, Wenzhi Sun, Woo-ping Ge and Yilong Wang in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221146128 for A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization by Baoshan Qiu, Zichen Zhao, Nan Wang, Ziyan Feng, Xing-jun Chen, Weiqi Chen, Wenzhi Sun, Woo-ping Ge and Yilong Wang in Journal of Cerebral Blood Flow & Metabolism

Background. Provisional side branch (SB) stenting strategy is the default approach for the majority of bifurcation lesions, but outcomes of SB is suboptimal. Though drug coated balloon (DCB) improving SB outcomes attracts an increasing attention, sequence of DCB hasn’t yet been determined. We presented a novel hybrid strategy of DCB and stent for bifurcation lesions. Methods. With lesion preparation, DCB was persistently inflated in SB kissing with main branch (MB) stent deployment and balloon post-dilation...

Background. Provisional side branch (SB) stenting strategy is the default approach for the majority of bifurcation lesions, but outcomes of SB is suboptimal. Though drug coated balloon (DCB) improving SB outcomes attracts an increasing attention, sequence of DCB hasn’t yet been determined. We presented a novel hybrid strategy of DCB and stent for bifurcation lesions. Methods. With lesion preparation, DCB was persistently inflated in SB kissing with main branch (MB) stent deployment and balloon post-dilation...

It’s worth noting that functional data analysis greatly enriches existing data analysis methods. It brings a broader perspective to investigate data structures. Thus, this thesis focuses on the field of functional data analysis and its extension methods. We begin by revisiting the fundamental methodologies of functional data analysis that support the overall concept of this thesis. After this explanatory stage, this thesis contributes three main parts. Part one concentrates on the application of the functional...

painting design and the detailed scene segmentation results

painting design and the detailed scene segmentation results

Supplemental Material for Surgical Treatment is Still Recommended for Patients Over 75 Years with IA NSCLC: A Predictive Model Based on Surveillance, Epidemiology and End Results Database by Cancer Control by Yafeng Liu, Wenting Zhang, Jing Wu, Wenyang Wang, Jiawei Zhou, Jianqiang Guo, Qingsen Wang, Xin Zhang, Jun Xie, Yingru Xing, and Dong Hu in Cancer Control

supplementary material 1

supplementary material 1

Potentilla kleiniana Wight et Arn（PK, ‘Wu Pi Feng’ in Chinese） was recorded as Miao ethnic medicine for treatment of fever, cough, ulcer, and erysipelas for thousands years. This study aimed to evaluate the antiviral activity of four PK extracts and seven compounds by using HIV-1 protease (HIV-1 PR). In addition, Ultra-High Performance Liquid Chromatography and High Resolution Mass Spectrometry (UPLC-HRMS) was employed to identify the bioactive components. The toxicity assessment of the extracts was done...

Extra simulations and experimental results

This study aimed to explore whether a relationship exists between dipping patterns and 1-year functional outcome in patients with acute ischemic stroke (IS) or transient ischemic attack (TIA). Data from the Blood Pressure and Clinical Outcome in TIA or Ischemic Stroke Study (BOSS), a nationwide, hospital-based, longitudinal cohort study, was used for this study. Patients with acute IS or TIA were recruited within 7 days after onset and ambulatory blood pressure monitoring was performed during...

Five extracts of the aerial parts of Aconitum carmichaeli were obtained by different solvent extraction or macroporous adsorption resin purification: ethyl acetate layer extract (EAE), n-butanol layer extract (BuE), water layer extract (WE), extract eluted by 10% ethanol from macroporous resin (10�), extract eluted by 80% ethanol from macroporous resin (80�). Antioxidant activities of the five extracts were determined by ABTS, DPPH, FRAP assays, anti-AChE activities by modified Ellman’s method, in vitro anti-hepatoma activities by...

Diseases caused by infections, such as helminth infections or viral infections, pose a major human health problem worldwide. In particular, one key reason why helminths cause long-term health and economic burdens is that there is currently no effective targeted vaccine for human use. B cell responses – resulting in the production of antibody – underpin most successful vaccine designs. This thesis uncovered MLL1 as a novel regulator of B cell responses to different pathogens, and...