Iron oxide nanoparticles (IONPs) are mostly intended to be administrated intravenously, understanding the interaction of IONPs with vascular endothelial cells is extremely crucial for developing safe application regimes of IONPs. In this work, interactions of three kinds of IONPs to endothelial cells were investigated both in human umbilical vein endothelial cells (HUVECs) and in healthy mice. Both meso-2,3-dimercaptosuccinic acid (DMSA) coated Fe3O4 NPs (DMSA-Fe3O4 NPs) and DMSA-Fe2O3 NPs induced cell growth inhibition, while polyglucose sorbitol...

A method for the preparation of primary amides from nitriles using hydrogen peroxide and a catalytic amount of sodium molybdate in ethanol is described. Using this method, nitriles including aromatic nitriles, aromatic heterocyclic nitriles and aliphatic nitriles were converted into the corresponding amides in moderate to high yields. Electronic and steric effects of substituent have a significant effect on the reactivity of nitrile, nitriles with electron-withdrawing group at the para or meta position show high...

Osteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO2@PA NPs) for osteosarcoma treatment. The MnO2 NPs oligomer was formed by PA modification with uniformed size...

The chemical epigenetic modifier 5-azacitidine (5-Aza C), a DNA methyltransferase inhibitor, was used to manipulate the endophytic fungus Penicillium sp. KMU18029. From its rice fermentation extract, a new polyketone compound (3S,4R)-3,4,8-trihydroxy-6-methyl-3,4-dihydronaphthalen-1(2H)-one (1), along with 13 known compounds, 3,4,8-trihydroxy-6-(hydroxymethyl)-3,4-dihydronaphthalen-1(2H)-one (2), decaturin B (3), 15-hydroxydecaturin A (4), oxalicine A (5), pileotin A (6), pyrandecarurin A (7), decaturenol A (8), decaturenoid (9), penisarins A (10), oxaline (11), (4E,8E)-N-D-2'-hydroxyocta-decanoyl-1-O-β-D-glycopy-ranosyl-9-methyl-4,8-sphingadienine (12), ergosterol (13) and stigma-5-en-3-O-β-glucoside (14), were separated. Among the...

Lonicera caerulea var. edulis, known as “blue honeysuckle” or “Haskap,” is a deciduous shrub that belongs to the Caprifoliaceae family. Characterized by the high cold hardiness and high quality of fruit, it has become a novel cash crop in cold regions worldwide. The lack of available chloroplast (cp) genome information limits studies of its molecular breeding and phylogeny. Here, the complete cp genome of Lonicera caerulea var. edulis was assembled and characterized for the first...

Bambusa tuldoides f. swolleninternode is an attractive ornamental bamboo species of southern China, with highly shortened and swollen at the base of internodes. In this study, the complete chloroplast genome of B. tuldoides was sequenced and reported for the first time. The complete genome size is 139,460 base pairs (bp), including a large single-copy (LSC) region of 82,996 bp, a small single-copy (SSC) region of 12,876 bp and a pair of invert repeats (IR) regions...

Juglans mandshurica Maxim., 1856 is a second-class, protected, rare tree species of high economic and ecological value. We elucidated the complete mitochondrial (mt) genome of J. mandshurica using the Illumina Novaseq 6000 and Nanopore platforms. The complete sequences of 558,032 and 161,386 bp had an overall GC content of 45.0% and 45.3%, respectively, and 61 genes could be annotated, including 38 protein-coding, 20 tRNA, and 3 rRNA genes. The high-quality J. mandshurica mt genomic sequences...

Lonicera caerulea var. edulis, known as “blue honeysuckle” or “Haskap,” is a deciduous shrub that belongs to the Caprifoliaceae family. Characterized by the high cold hardiness and high quality of fruit, it has become a novel cash crop in cold regions worldwide. The lack of available chloroplast (cp) genome information limits studies of its molecular breeding and phylogeny. Here, the complete cp genome of Lonicera caerulea var. edulis was assembled and characterized for the first...

The aim of the study was to systematically explore the relationships between various adipokines and risks of endometrial atypical hyperplasia (EAH), type I endometrial cancer (EC), and type II EC. We enrolled 219 patients in this study, including 39 EAH, 87 type I EC, 38 type II EC and 55 control individuals. We subsequently explored the association of adipokine levels and the leptin-to-adiponectin (L/A) ratio with EAH, type I EC, and type II EC. The...

Supplemental material, sj-docx-1-oed-10.1177_25158414221139002 for A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy by Ruilin Xiong, Wei Wang, Xianwen Shang, Yixiong Yuan, Yifan Chen, Lei Zhang, Katerina V Kiburg, Zhuoting Zhu and Mingguang He in Therapeutic Advances in Ophthalmology

Supplementary Material

Supplemental Material for Pipeline fault simulation and control of a liquid rocket engine by Yuqiang Cheng, Runsheng Hu, and Jianjun Wu in Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering

Supplemental material, sj-docx-1-tan-10.1177_17562864231154976 for Short-term outcome prediction for myasthenia gravis: an explainable machine learning model by Huahua Zhong, Zhe Ruan, Chong Yan, Zhiguo Lv, Xueying Zheng, Li-Ying Goh, Jianying Xi, Jie Song, Lijun Luo, Lan Chu, Song Tan, Chao Zhang, Bitao Bu, Yuwei Da, Ruisheng Duan, Huan Yang, Sushan Luo, Ting Chang and Chongbo Zhao in Therapeutic Advances in Neurological Disorders

Supplemental Material for The Extract of Acanthopanacis Cortex Relieves the Depression-Like Behavior and Modulates IL-17 Signaling in Chronic Mild Stress-Induced Depressive Mice by Chuhan Liu, Lu Yan, Yiyun Qian, Pingping Song, Tao Wang, and Min Wei in Dose-Response

Supplemental Material for The Extract of Acanthopanacis Cortex Relieves the Depression-Like Behavior and Modulates IL-17 Signaling in Chronic Mild Stress-Induced Depressive Mice by Chuhan Liu, Lu Yan, Yiyun Qian, Pingping Song, Tao Wang, and Min Wei in Dose-Response

Detailed parameter

Detailed parameter

Detailed parameter

Detailed parameter

Spontaneous imbibition is one of the important means to enhance oil recovery in low permeability reservoirs, and it has good field application effects. Through the interfacial tension (IFT), contact angle (CA), and adsorption experiments, the effects of SDBS surfactant on IFT and reservoir wettability were studied, and the adsorption rule of SDBS at the mineral surface was obtained. On this basis, the imbibition recovery and mechanism of cores with different permeability are studied. The study...

Supplement 1

Supplemental material, sj-docx-1-acr-10.1177_02841851231158730 for Performance of machine learning-based coronary computed tomography angiography for selecting revascularization candidates by Zengfa Huang, Yi Ding, Yang Yang, Shengchao Zhao, Shutong Zhang, Jianwei Xiao, Chengyu Ding, Ning Guo, Zuoqin Li, Shiguang Zhou, Guijuan Cao and Xiang Wang in Acta Radiologica

HLX02, the first China-manufactured trastuzumab biosimilar, is approved in Europe (EU) and China. This study evaluated bioequivalence between HLX02 and US-approved trastuzumab (US-trastuzumab). In this double-blind, parallel-group, Phase I study, healthy Chinese men were randomized (1:1:1) to receive a single 6 mg/kg dose of HLX02, reference US-trastuzumab, or reference EU-approved trastuzumab (EU-trastuzumab). Equivalence in PK profiles was demonstrated if the 90% confidence intervals (CIs) for the geometric mean ratio (GMR) for the difference between the...

HLX02, the first China-manufactured trastuzumab biosimilar, is approved in Europe (EU) and China. This study evaluated bioequivalence between HLX02 and US-approved trastuzumab (US-trastuzumab). In this double-blind, parallel-group, Phase I study, healthy Chinese men were randomized (1:1:1) to receive a single 6 mg/kg dose of HLX02, reference US-trastuzumab, or reference EU-approved trastuzumab (EU-trastuzumab). Equivalence in PK profiles was demonstrated if the 90% confidence intervals (CIs) for the geometric mean ratio (GMR) for the difference between the...

Anaplastic lymphoma kinases (ALK) tyrosine kinase inhibitors (TKIs) are effective and safe targeted therapies used in advanced ALK-positive non-small cell lung cancers (NSCLC). However, ALK-TKIs associated cardiovascular toxicities in patients with ALK-positive NSCLCremain incompletely characterized. We conducted the first meta-analysis to investigate this. To determine the cardiovascular toxicities associated with these agents, we carried out a meta-analysis comparing ALK-TKIs with chemotherapy and a meta-analysis comparing crizotinib with other ALK-TKIs. Statistical analysis was conducted to calculate...