Speleothems (secondary calcium carbonate formations) offer significant potential for recording environmental processes above caves, an area increasingly referred to as the Critical Zone. Speleothems grow for hundreds to millions of years, with absolute chronology from U-Th and U-Pb chronometers. The solution properties of rainwater infiltrating the soil and underlying caves respond to environmental controls. These environmental signals can be preserved within speleothem carbonates. Recent efforts to calibrate, model and interpret this complex geochemistry has progressed...

Welches Wissen und welche Kompetenzen brauchen Lehr- und Fachkräfte für die gelingende Beziehungsarbeit im Kontext von sozialer Benachteiligung? Was brauchen Kinder und Jugendliche im Schulalltag von ihnen? Und welche Antworten können Fortbildung bzw. Professionalisierung hier geben? In einem Kooperationsprojekt mit Prof. Dr. Tanja Betz von der Johannes Gutenberg-Universität Mainz wurden diese Fragen bearbeitet. Die Forschungsergebnisse zeigen, dass Habitussensibilität, also die bewusste und professionelle Vergegenwärtigung von Lebenslagen, Denkmustern und Alltagskultur, in der Beziehungsarbeit eine zentrale Rolle...

Investigation of the leaves of Bauhinia thonningii Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether (1) together with eleven known compounds (2–13), with two of them (10 and 11) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound 1 as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of Staphylococcus...

Supplemental material, sj-docx-1-tan-10.1177_17562864221142924 for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study by Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp and Stefan Bittner in Therapeutic Advances in Neurological Disorders

Additional file 1. Supplementary Results, Supplementary Methods and Appendix A.

Additional file 1: Suppl. Fig. 1. RET fusions were identified in 3 patients. A. H&E and α-thyroglobulin staining of indicated patients’ tumor tissues. B. Summary of patients’ features. C. Circos plots showing RET fusions detected in patients 14, 15 and 21. D./E. RET fusions detection by qPCR (E) and RT-PCR (F) in indicated samples. F. BAIAP2L1-BRAF detection by qPCR (upper panel) and RT-PCR (lower two panels) in the indicated patients’ samples. The upper graph shows...

Additional file 1: Figure S1. Expression of endogenic and transgenic CLU and S100B sequences in transfected HN33 cell lines at normoxia, determined by qPCR experiments. Differences in Ct-values between endogenic and transgenic nCLU, sCLU and S100B were 13.17 (with Ct of 40 for endogenic nCLU), 13.25 and 9.48, respectively. The fold-expression difference for nCLU, sCLU and S100B therefore were 213.17, 213.25 and 29.48, respectively. Figure S2. TPM values of endogenic (CLU, S100B) and transgenic [CLU...

Additional file 1: Figure S1. Expression of endogenic and transgenic CLU and S100B sequences in transfected HN33 cell lines at normoxia, determined by qPCR experiments. Differences in Ct-values between endogenic and transgenic nCLU, sCLU and S100B were 13.17 (with Ct of 40 for endogenic nCLU), 13.25 and 9.48, respectively. The fold-expression difference for nCLU, sCLU and S100B therefore were 213.17, 213.25 and 29.48, respectively. Figure S2. TPM values of endogenic (CLU, S100B) and transgenic [CLU...

Supplementary Material 1

Investigation of the leaves of Bauhinia thonningii Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether (1) together with eleven known compounds (2–13), with two of them (10 and 11) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound 1 as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of Staphylococcus...

Supplemental material, sj-docx-1-tan-10.1177_17562864221142924 for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study by Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp and Stefan Bittner in Therapeutic Advances in Neurological Disorders

Additional file 1. Supplementary Results, Supplementary Methods and Appendix A.

Additional file 1: Supplementary Note S1. Assembly of Neoechinorhynchus buttnerae draft genome. Supplementary Note S2. Assembly of Neoechinorhynchus agilis draft genome. Supplementary Table S1. Transcript abundance differences of candidates. Supplementary Table S2. Amino acid composition of candidate target proteins. Supplementary Table S3. Properties of target proteins. Supplementary Table S4. PFAM motifs of target proteins. Supplementary Table S5. 3D structure prediction of target proteins. Supplementary Table S6. Virtual ligand screening results. Supplementary Table S7. Bacterial genome...

Supplementary Material 1

Biblische Vorstellungswelten vor allem der Reinheitsbestimmungen in Levitikus initiieren (grenzziehende) Körperpraktiken und dienen somit als Krisenbewältigungsmodell, nicht zuletzt im Kontext der Covid-19-Pandemie. Dies nimmt der Beitrag als Ausgangspunkt, um die Rezeptionsgeschichte der biblischen Reinheitsbestimmungen, wie sie sich in die Sprache, Pandemie- und Medizingeschichte eingeschrieben haben, darzulegen. Denn der immunologische Diskurs und die gegenwärtige (virologische) Rede im Kontext der Covid-19-Pandemie ist von älteren (u. a. biblischen) Vorstellungen überlagert. Dies gilt es zu verstehen und kritisch zu...

Additional file 1: Suppl. Fig. 1. RET fusions were identified in 3 patients. A. H&E and α-thyroglobulin staining of indicated patients’ tumor tissues. B. Summary of patients’ features. C. Circos plots showing RET fusions detected in patients 14, 15 and 21. D./E. RET fusions detection by qPCR (E) and RT-PCR (F) in indicated samples. F. BAIAP2L1-BRAF detection by qPCR (upper panel) and RT-PCR (lower two panels) in the indicated patients’ samples. The upper graph shows...

Additional file 1: Supplementary Note S1. Assembly of Neoechinorhynchus buttnerae draft genome. Supplementary Note S2. Assembly of Neoechinorhynchus agilis draft genome. Supplementary Table S1. Transcript abundance differences of candidates. Supplementary Table S2. Amino acid composition of candidate target proteins. Supplementary Table S3. Properties of target proteins. Supplementary Table S4. PFAM motifs of target proteins. Supplementary Table S5. 3D structure prediction of target proteins. Supplementary Table S6. Virtual ligand screening results. Supplementary Table S7. Bacterial genome...

Speleothems provide a great opportunity for paleoclimate reconstruction because they occur almost worldwide and can be dated very precisely using the U-series disequilibrium method. The most commonly used climate proxies are stable isotope values (δ18O and δ13C) and trace elements. However, these are influenced by a variety of surface and in-cave processes, which results in a non-trivial interpretation of the speleothem proxy signals. The last glacial period and in particular the Marine Isotope Stage (MIS)...