64 Works

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

Simona Capponi, Nadja Stöffler, Manuel Irimia, Frederik M.A. Van Schaik, Mercedes M. Ondik, Martin L. Biniossek, Lisa Lehmann, Julia Mitschke, Marit W. Vermunt, Menno P. Creyghton, Ann M. Graybiel, Thomas Reinheckel, Oliver Schilling, Benjamin J. Blencowe, Jill R. Crittenden & H. Th. Marc Timmers
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34ʹ is included in the neuronal form of TAF1 mRNA, which encodes the largest subunit of the basal transcription factor TFIID. In this study, we investigate the tissue distribution of TAF1-34ʹ mRNA and protein and the mechanism responsible for its neuronal-specific splicing. Using isoform-specific RNA probes and antibodies,...

Just Popular Entertainment or Longing for a Posthuman Eden?

Stephanie Bender
In the context of the ecological crisis, tales of the apocalypse have become a regular feature of the contemporary cultural imaginary, be it in popular feature films, non-fictional texts, or dystopian novels. Margaret Atwood’s MaddAddam Trilogy (2004 [2003], 2010 [2009], 2014 [2013]) investigates this curious form of entertainment both by employing the template of the apocalypse itself and by reflecting on its cause and effect at the same time. The novels reveal how worlds and...

Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway

Qi Yang, Jia You, Yuan Zhou, Yun Wang, Rongjuan Pei, Xinwen Chen, Min Yang & Jizheng Chen
Tick-borne encephalitis virus (TBEV) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia and causes encephalitis in humans. In this study, we demonstrate TBEV appears to activate the interferon (IFN)-β dependent on RIG-I/MDA5. Both the IFN-β accumulation and the IFN stimulated genes (ISGs) transcription greatly delay. Further studies reveal that TBEV NS4A could block the phosphorylation and dimerization of STAT1/STAT2 to affect type I and II IFN-mediated STAT signalling. Additional data...

From zero deforestation to zero illegality: Discussing practices of territorialization in Southwest Pará

Michael Klingler & Philipp Mack
Presentation given at the 2nd Austrian Conference on International Resource Politics: Resources for a social-ecological transformation, 28th February - 2nd March 2019, Innsbruck/Austria.
Environmental policy changes and supply chain interventions greatly influenced the post-2004 deforestation slowdown in the Brazilian Amazon. Nevertheless, since 2012 deforestation rates are on the rise again. Especially in Southwest Pará, where the frontier dynamics of speculative deforestation and illegal cattle ranching are ubiquitous, deforestation is far from ‘zero’. Even though a series...

Professionsorientierte Fachwissenschaft als Element der Allgemeinen Fachdidaktik

Eva-Maria Spiegelhalter
Konzepte der fachlichen Bildung sind Elemente einer Allgemeinen Fachdidaktik. Die Bedeutung fachlicher Bildung im Bildungsprozess ist bisher nicht eindeutig geklärt. Am Freiburg Advanced Center of Education (FACE) werden aktuell in den Domänen Germanistik, Romanistik und Theologie Lehrprojekte konzipiert, die eine professionsorientierte Fachwissenschaft fokussieren. Professionsorientierte Fachwissenschaft zielt auf den Aufbau eines fachwissenschaftlichen Wissens, das strukturell auf die spätere professionelle Tätigkeit ausgerichtet ist. Der Artikel arbeitet heraus, welchen Beitrag professionsorientierte Fachwissenschaft zum Konzept der fachlichen Bildung leistet,...

Geoscience Education for the Young Generation: mileko - The Mineralogical Science Kit

Maria Mrosko , Lennart A. Fischer , Lutz Hecht , Bastian Joachim-Mrosko , Malte Junge , Gilla Simon & Roland Stalder
Geosciences only play a minor role in today’s German and Austrian school curricula, although being strongly related to important topics such as climate change and sustainability of resources. The Mineralogical Science Kit (Mineralogischer Lehrkoffer ‘mileko’) aims at bringing back geoscientific and mineralogical contents into STEAM-fields (science, technology, engineering, art, mathematics) by linking mineralogy to regular teaching subjects. In 5 different modules pupils can not only discover the world of rocks and minerals but also get...

Additional file 1 of An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research

Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl & Lukas Schwingshackl
Additional file 1: Appendix S1. Search strategy. Tables S1-S5. Table S1. Explanation and definition for PI/ECO similarity degree. Table S2. PI/ECO similarity degree. Table S3. Differences between published (reported) effect estimates and re-calculated effect estimates. Table S4. Reason for exclusion from the pooling scenario. Table S5. Pooling results. Figures S1-S118. Fig S1. Forest plot: Low sodium (Intervention/Exposure); All-cause mortality (Outcome). Fig. S2. Forest plot: Low sodium; Cardiovascular disease. Fig. S3. Forest plot: Intra-aortic balloon pump;...

Privilegienblindes Reisen in Zeiten des Klimawandels

Nina Degele
In Germany, travelling is taken for granted without question. However, it is predominantly practiced by privileged people. This paper discusses climate conscious travelling and unfolds the associated privileges by reconstructing strategies of legitimizing travel practices. Moreover, "flight shame" is discussed as a strategy to reconstruct moral standards of privileges. The empirical basis is provided through discussions with six groups of middle-class people in rural towns as well as urban cities in southern Germany who differ...

sj-docx-1-tag-10.1177_17562848221100106 – Supplemental material for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Supplemental material, sj-docx-1-tag-10.1177_17562848221100106 for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study by Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker and Rohini Sharma in Therapeutic Advances in Gastroenterology

Additional file 1 of SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

De-long Wu, Yun Wang, Ting-juan Zhang, Ming-qiang Chu, Zi-jun Xu, Qian Yuan, Ji-chun Ma, Jiang Lin, Jun Qian & Jing-dong Zhou
Additional file 1: Figure S1. Correlation between SLIT2 methylation density detected by BSP and SLIT2 methylation level detected by RT-qMSP.

Additional file 1 of SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

De-long Wu, Yun Wang, Ting-juan Zhang, Ming-qiang Chu, Zi-jun Xu, Qian Yuan, Ji-chun Ma, Jiang Lin, Jun Qian & Jing-dong Zhou
Additional file 1: Figure S1. Correlation between SLIT2 methylation density detected by BSP and SLIT2 methylation level detected by RT-qMSP.

Deep hydrochemical profile through the Alps – solute acquisition during distinct water-rock-interaction along the Sedrun section of the Gotthard Base Tunnel

Ingrid Stober & Kurt Bucher
During drilling of the Gotthard Base Tunnel through the Central Alps the exposed fractured rocks and the frequent water inflows provided a deep insight into regional hydrogeological processes in orogenic crystalline basements. Here we report data from the 10 km long central Sedrun section. 211 water samples were collected from frequent inflow points at 900 to 2350 m below the surface. The singular samples and data provide a comprehension of the deep hydrochemical cross-section through...

Additional file 1 of Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Victoria Constanze Landwehr, Tobias Fretwurst, Julia Heinen, Kirstin Vach, Katja Nelson, Susanne Nahles & Gerhard Iglhaut
Additional file 1. Supplement 1. Body mass index (BMI), 17β-estradiol, testosterone, sex hormone binding globulin and meannew bone formation (NBF) in female and male patients. Supplement 2. Reference ranges (a) of the body mass index (BMI), according to the World HealthOrganization (WHO, 2000), regardless of gender and (b) of the sex steroid hormone serumconcentrations according to the criteria of the Labor Berlin - Charité Vivantes GmbH.

Additional file 1 of Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Additional file 1: Table S1: Details about the antibodies used in the study.

Additional file 11 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 10. Fig. S1. Cell cycle analysis and sensitivity to inhibitors in BRAFV600E mutant MaMel cells. Fig. S2. Apoptotic and proliferative response of BRAFV600E mutant MaMel cells under inhibition. Fig. S3. MITF/AXL ratios in BRAFV600E mutant MaMel cells. Fig. S4. Over-represented targets of transcription factors within groups of genes correlated with the degree of resistance in BRAFV600E mutant MaMel cells. Fig. S5. Transcriptome profiles of melanoma cells with different NRAS/BRAF mutation status and degrees...

Additional file 11 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 10. Fig. S1. Cell cycle analysis and sensitivity to inhibitors in BRAFV600E mutant MaMel cells. Fig. S2. Apoptotic and proliferative response of BRAFV600E mutant MaMel cells under inhibition. Fig. S3. MITF/AXL ratios in BRAFV600E mutant MaMel cells. Fig. S4. Over-represented targets of transcription factors within groups of genes correlated with the degree of resistance in BRAFV600E mutant MaMel cells. Fig. S5. Transcriptome profiles of melanoma cells with different NRAS/BRAF mutation status and degrees...

Additional file 1 of Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Additional file 1.

Octavio Paz, Carlos Castaneda y la búsqueda de otra dimensión de la realidad

Hermann Herlinghaus
pp. 91-106 This study is dedicated to the prologue Octavio Paz wrote for the second Mexican edition of Castaneda’s The Teachings of Don Juan: A Yaqui Way of Knowledge (1968), entitled “La mirada anterior.” It discusses a problematic of great relevance for Paz which, however, was thoroughly underestimated by the major part of scholarly work on the Mexican author. At issue is Paz’ interest in psychoactive phenomena in relationship to cultural creation and, especially, regarding...

Additional file 1 of Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Additional file 1: Fig. S1. Photograph of the common carotid artery and AVF after surgery. A. Right common carotid artery in normal mice. B. This picture shows the anastomosis of common carotid artery with internal jugular vein in AVF after surgery. The yellow arrow points to the sutures. The inflated jugular vein indicates the patency of the AVF. Scale bars = 1 mm. Fig. S2. Notch signaling conducts signals between neighboring cells. There are 5...

Additional file 2 of Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Additional file 2: Table S1. List of antibodies used in this study.

Additional file 1 of Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Additional file 1: Fig. S1. Photograph of the common carotid artery and AVF after surgery. A. Right common carotid artery in normal mice. B. This picture shows the anastomosis of common carotid artery with internal jugular vein in AVF after surgery. The yellow arrow points to the sutures. The inflated jugular vein indicates the patency of the AVF. Scale bars = 1 mm. Fig. S2. Notch signaling conducts signals between neighboring cells. There are 5...

Additional file 1 of Early clinical course of biopsy-proven IgA vasculitis nephritis

Sarina Butzer, Imke Hennies, Charlotte Gimpel, Jutta Gellermann, Gesa Schalk, Sabine König, Anja K. Büscher, Anja Lemke & Martin Pohl
Additional file 1. Comparative subgroup analysis. Of 66 patients, we identified 28 children with crescentic glomeruli and/or nephrotic syndrome at onset of IgAVN. Referring to the German Society of Pediatric Nephology, a corticosteroid pulse therapy only would have been recommended. Of these 28 children, 17 received corticosteroid pulse therapy per protocol, 11 did not receive any immunosuppressive therapy. We therefore performed a comparative subgroup analysis which showed similar improvements of clinical symptoms and proteinuria.

Additional file 1 of Required displacement factors for evaluating and comparing climate impacts of intensive and extensive forestry in Germany

Buschbeck Christian & Pauliuk Stefan
Additional file 1: Table S1. Wood and carbon stocks in living trees in BL.Table S2. Wood and carbon stocks in living trees in WPS. Table S3. Wood and carbon stocks in living trees in NPS. Table S4. Deadwood stocks with the corresponding carbon masses for WPS and NPS. Table S5. Total carbon stocks in the forest. Table S6. Conversion factors for carbon in different tree species groups. Table S7. Wood and carbon volumes extracted in...

Additional file 3 of Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study

Julia Stadelmaier, Isabelle Roux, Maria Petropoulou & Lukas Schwingshackl
Additional file 3: Table S1. Exclusion reasons for highly correlated outcomes (Random sequence). Table S2. Exclusion reasons for highly correlated outcomes (Allocation concealment). Table S3. Exclusion reasons for highly correlated outcomes (Blinding of participants/personnel). Table S4. Exclusion reasons for highly correlated outcomes (Blinding of outcome assessment). Table S5. Exclusion reasons for highly correlated outcomes (Incomplete outcome data). Table S6. Exclusion reasons for highly correlated outcomes (Selective Reporting). Table S7. Exclusion reasons for highly correlated outcomes...

Additional file 1 of Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study

Julia Stadelmaier, Isabelle Roux, Maria Petropoulou & Lukas Schwingshackl
Additional file 1: Appendix 1. Inclusion and exclusion criteria. Appendix 2. Search strategy.

Registration Year

  • 2023
    4
  • 2022
    43
  • 2021
    6
  • 2020
    5
  • 2019
    6

Resource Types

  • Text
    64

Affiliations

  • University of Freiburg
    64
  • University Medical Center Freiburg
    16
  • Shanghai Jiao Tong University
    12
  • Affiliated Hospital of Jiangsu University
    12
  • Jinan University
    11
  • First Affiliated Hospital of Chengdu Medical College
    11
  • Anhui Medical University
    11
  • Hunan University of Arts and Science
    10
  • Tongji Hospital
    10
  • Zhengzhou University
    10