6 Works
Les émotions comme signe d’humanité ou les larmes dans le test de Turing
Eva Voldřichová BeránkováEmojis as a Language of their Own
Dmitriy Agranovskiy & Alina Avilova
Emojis are a product of computer mediated communication. As a means of expressing emotion, indicating the illocutionary force or the intended tone, they are well-researched. However, emojis are rarely seen as a visual language in their own right. The article analyzes the syntax and semantics semantics of emojis and people’s ability to interpret them. The research method for this article was an online survey. An emoji rendering of the title of a literary work was...
Amelogenesis and tribosphenic molars: patterns and variation.
Ivan Horacek , Pavla Hanouskova & Anna Kallistova
(1) University of California, Santa Barbara, CA (UCSB) Department of Zoology, Charles University, Vinicna 7, Cz 128 44 Prague, Czech Republic; (2) University of California, Santa Barbara, CA (UCSB), USA
The tribosphenic molar presents phylotypic stage of the mammalian dental evolution. A study of its enamel microarchitecture in several clades (Chiroptera, Afrosoricida, Eulipotyphla, Didelphomorhia, Cetartiodactyla) revealed, apart of considerable taxon-specific variation, a set of structural (i-iii) and developmental (iv-x) characteristics common to all: (i)...
The tribosphenic molar presents phylotypic stage of the mammalian dental evolution. A study of its enamel microarchitecture in several clades (Chiroptera, Afrosoricida, Eulipotyphla, Didelphomorhia, Cetartiodactyla) revealed, apart of considerable taxon-specific variation, a set of structural (i-iii) and developmental (iv-x) characteristics common to all: (i)...
Rudolf Veselý, 1931–2020
Josef ŽenkaComputational study of novel inhibitory molecule, 1-(4-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-phenylurea, with high potential to competitively block ATP binding to the RNA dependent RNA polymerase of SARS-CoV-2 virus
Prem Prakash Sharma, Sumit Kumar, Sukrit Srivastava, Mitul Srivastava, Babban Jee, Nikolay Yu. Gorobets, Dhruv Kumar, Mukesh Kumar, Shailendra Asthana, Peng Zhang, Poonam, Martin Zoltner & Brijesh Rathi
For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive in silico screening for 16,776 potential molecules from recently established drug libraries based on two important pharmacophores (3-amino-4-phenylbutan-2-ol and piperazine). Based on initial assessment, 4042 molecules were obtained suitable as drug candidates, which were following Lipinski’s rule. Molecular docking...
Computational study of novel inhibitory molecule, 1-(4-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-phenylurea, with high potential to competitively block ATP binding to the RNA dependent RNA polymerase of SARS-CoV-2 virus
Prem Prakash Sharma, Sumit Kumar, Sukrit Srivastava, Mitul Srivastava, Babban Jee, Nikolay Yu. Gorobets, Dhruv Kumar, Mukesh Kumar, Shailendra Asthana, Peng Zhang, Poonam, Martin Zoltner & Brijesh Rathi
For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive in silico screening for 16,776 potential molecules from recently established drug libraries based on two important pharmacophores (3-amino-4-phenylbutan-2-ol and piperazine). Based on initial assessment, 4042 molecules were obtained suitable as drug candidates, which were following Lipinski’s rule. Molecular docking...
Affiliations
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Charles University6
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China Astronaut Research and Training Center2
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Indian Institute of Technology Roorkee2
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Sun Yat-sen University2
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Huazhong University of Science and Technology2
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Shandong Tumor Hospital2
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Indian Agricultural Research Institute2
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Beijing Normal University2
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All India Institute of Medical Sciences2
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First Affiliated Hospital of Xi'an Jiaotong University2