6 Works

Les émotions comme signe d’humanité ou les larmes dans le test de Turing

Eva Voldřichová Beránková

Emojis as a Language of their Own

Dmitriy Agranovskiy & Alina Avilova
Emojis are a product of computer mediated communication. As a means of expressing emotion, indicating the illocutionary force or the intended tone, they are well-researched. However, emojis are rarely seen as a visual language in their own right. The article analyzes the syntax and semantics semantics of emojis and people’s ability to interpret them. The research method for this article was an online survey. An emoji rendering of the title of a literary work was...

Amelogenesis and tribosphenic molars: patterns and variation.

Ivan Horacek , Pavla Hanouskova & Anna Kallistova
(1) University of California, Santa Barbara, CA (UCSB) Department of Zoology, Charles University, Vinicna 7, Cz 128 44 Prague, Czech Republic; (2) University of California, Santa Barbara, CA (UCSB), USA

The tribosphenic molar presents phylotypic stage of the mammalian dental evolution. A study of its enamel microarchitecture in several clades (Chiroptera, Afrosoricida, Eulipotyphla, Didelphomorhia, Cetartiodactyla) revealed, apart of considerable taxon-specific variation, a set of structural (i-iii) and developmental (iv-x) characteristics common to all: (i)...

Rudolf Veselý, 1931–2020

Josef Ženka

Computational study of novel inhibitory molecule, 1-(4-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-phenylurea, with high potential to competitively block ATP binding to the RNA dependent RNA polymerase of SARS-CoV-2 virus

Prem Prakash Sharma, Sumit Kumar, Sukrit Srivastava, Mitul Srivastava, Babban Jee, Nikolay Yu. Gorobets, Dhruv Kumar, Mukesh Kumar, Shailendra Asthana, Peng Zhang, Poonam, Martin Zoltner & Brijesh Rathi
For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive in silico screening for 16,776 potential molecules from recently established drug libraries based on two important pharmacophores (3-amino-4-phenylbutan-2-ol and piperazine). Based on initial assessment, 4042 molecules were obtained suitable as drug candidates, which were following Lipinski’s rule. Molecular docking...

Computational study of novel inhibitory molecule, 1-(4-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-phenylurea, with high potential to competitively block ATP binding to the RNA dependent RNA polymerase of SARS-CoV-2 virus

Prem Prakash Sharma, Sumit Kumar, Sukrit Srivastava, Mitul Srivastava, Babban Jee, Nikolay Yu. Gorobets, Dhruv Kumar, Mukesh Kumar, Shailendra Asthana, Peng Zhang, Poonam, Martin Zoltner & Brijesh Rathi
For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive in silico screening for 16,776 potential molecules from recently established drug libraries based on two important pharmacophores (3-amino-4-phenylbutan-2-ol and piperazine). Based on initial assessment, 4042 molecules were obtained suitable as drug candidates, which were following Lipinski’s rule. Molecular docking...

Registration Year

  • 2021
    6

Resource Types

  • Text
    6

Affiliations

  • Charles University
    6
  • China Astronaut Research and Training Center
    2
  • Indian Institute of Technology Roorkee
    2
  • Sun Yat-sen University
    2
  • Huazhong University of Science and Technology
    2
  • Shandong Tumor Hospital
    2
  • Indian Agricultural Research Institute
    2
  • Beijing Normal University
    2
  • All India Institute of Medical Sciences
    2
  • First Affiliated Hospital of Xi'an Jiaotong University
    2