Directed acyclic graph (DAG) models are widely used to represent casual relationships among random variables in many application domains. This article studies a special class of non-Gaussian DAG models, where the conditional variance of each node given its parents is a quadratic function of its conditional mean. Such a class of non-Gaussian DAG models are fairly flexible and admit many popular distributions as special cases, including Poisson, Binomial, Geometric, Exponential, and Gamma. To facilitate learning,...

CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

Additional file 1: Figure S1. SEM of TCNH. Figure S2. EDS of TCN. Figure S3. Optimization of the H2O2 and TCNH concentrations. Figure S4. In vitro antibacterial activity of TCNH against MDR P. aeruginosa (20059, 21173, 21715). Representative photographs of bacterial colonies after intervened by saline, H2O2, TCNH, and TCNH+H2O2. Figure S5. Immunostaining analysis of macrophages and neutrophils in mouse corneas after saline, H2O2, TCNH, and TCNH+H2O2 interventions. Figure S6. In vivo antibacterial activities of...

Online question and answer (Q&A) community users’ knowledge contribution behaviour was studied using primary and secondary data and different research approaches. However, this topic is never explored in the context of content (knowledge) shared in these communities. Furthermore, online social interaction's role as a mediator is also ignored in online Q&A communities. This study model explored community recognition, online social interaction, devotion to community, self-satisfaction, and a sense of reciprocation's role in the knowledge contribution...

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Additional file 1: Table S1. Differentially expressed proteins identified in plasma samples.

Supplemental material, sj-pdf-1-jva-10.1177_11297298221131395 for Venipuncture-related traumatic neuroma of the ulnar nerve on the dorsal of a hand: A case report by Yidan Chen, Linfang Zhao and Chang Liu in The Journal of Vascular Access

Additional file 1: Table S1. A list of manually selected variables. Table S2. Process of algorithm-based variable selection. Table S3. Coding of selected variables for LCA. Table S4. Goodness-of-fit statistics of 2-5 classes. Table S5. Partial probabilities of subgroup membership for selected variables. Table S6. Weighted estimated of demographic features and treatment arm of 3 groups.

Additional file 3: Supplemental Figure 1. Boxplots showing the abundance of Menaquinone biosynthesis, Chorismate biosynthesis, Penicillin resistance and Heme biosynthesis in TB-E and TB-NE samples.

Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4′′′-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (1), 4′′′-hydroxyphenethyl(4′-hydroxy-3′-methoxyphenyl)propionate (2) and 4′′-hydroxyphenethyl ethyl succinate (3), together with 5 known compounds, ferulic acid (4), L-phenyllactic acid (5), hydroxytyrosol (6), dihydroferulic acid (7), cyclo(L-Pro-D-Tyr) (8). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound 2...

Colorectal cancer (CRC) is a common gastrointestinal cancer with high incidence and mortality rates. CRC may be associated with regulation of circulating nucleotides. This study aimed to evaluate the serum levels of nucleotide-metabolizing enzymes (ATPase and AMPase) in patients with CRC and to explore the clinical diagnostic value of these enzymes. The gene set variation analysis (GSVA) score of the ATP-adenosine signature was calculated using tumor samples from The Cancer Genome Atlas (TCGA). ATP-adenosine signaling...

In this work, the influence of sand impingements on cathodic protection (CP) of marine carbon steel in natural sea water was studied in comparison with the CP performances in static and flowing sea water without sand particles. Results show that the propagation of local active anodic dissolution at the steel inclusions could be totally inhibited by providing sufficient cathodic current in the sea water free of sand particles. However, the local ‘CP shielding’, potential fluctuation...

Additional file1. Fig S1: The flow chart of this study. HCC, hepatocellular carcinoma. TMB, tumor mutation burden. TME, tumor microenvironment. GSVA, gene set variation analysis. GO, Gene Ontology. KEGG, Kyoto Encyclopedia.

Additional file 1. Supplementary methods

Additional file 1. Supplementary methods

Supplemental material, sj-docx-1-hij-10.1177_19401612211020929 for Campaign Advertising and the Cultivation of Crime Worry: Testing Relationships With Two Large Datasets From the 2016 U.S. Election Cycle by Jiawei Liu, Rosemary J. Avery, Erika F. Fowler, Laura Baum, Sarah E. Gollust, Colleen L. Barry, Brendan Welch, Emmett Tabor, Nathaniel W. Lee and Jeff Niederdeppe in The International Journal of Press/Politics

Additional file 1: Table S1. Clinical baseline characteristics of 101 patients with HCC according to CEBPA-DT expression level. Table S2. Prognostic factors for overall survival and recurrence-free survival by the univariate Cox proportional hazards regression model. Table S3. Independent prognostic factors for overall survival and recurrence-free survival by the multivariate Cox proportional hazards regression model. Table S4. The antibodies used in this study. Table S5. Sequence of primers used for PCR in this study. Table...

Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into...

Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into...

To discover new agrochemicals with prominent pesticidal properties, a series of novel β-naphthol derivatives containing benzothiazolylamino and various heteroaryl groups (8a-q) were efficiently synthesised via Betti reaction. The bioassay results showed that most of the synthesised compounds exhibited favourable insecticidal potentials, particularly towards oriental armyworm (50–100% at 200 mg·L−1) and diamondback moth (50–95% at 10 mg·L−1). Compounds 8 b, 8f, 8 g, 8j, 8k, 8n, and 8o possessed LC50 values of 0.0988–5.8864 mg·L−1 against diamondback...

Supplemental material, sj-docx-1-isp-10.1177_00207640221141784 for Social anxiety and depression symptoms in Chinese left-behind children after the lifting of COVID-19 lockdown: A network analysis by Kuiliang Li, Lei Ren, Lei Zhang, Chang Liu, Mengxue Zhao, Xiaoqing Zhan, Ling Li, Xi Luo and Zhengzhi Feng in International Journal of Social Psychiatry

Hepatitis E virus (HEV) is a pathogen of global significance, but the value of HEV-related markers in the diagnosis of hepatitis E remains controversial. Previous studies on hepatitis E profiles have been mainly cross-sectional and conducted among inpatients in large hospitals, and hepatitis E cases have been primarily defined by limited partial markers. In this community-based study, 4,110 active hepatitis cases from a population of nearly 600,000 were followed over 48 months and serial serum...

Additional file 1: Supplementary Table 1. Results of GLM that examined the relationships between HABs and neurodegenerative diseasesα with different sizes of radius. Supplementary Fig. 1. Microscopic images (× 400) of cyanobacteria were captured from an outer layer of the personal mask from a fisherman working downstream of the Nakdong River (Daedong Dock (35.239992 (latitude), 128.996558 (longitude)). Supplementary Table 2. Concentrations of microcystins and BMAA from the air and water samples collected downstream of Nakdong...

We assessed whether personal exposure to household air pollution [PM2.5 and black carbon (BC)] is associated with lung functions (FEV1, FVC, and their ratio) in non-smoking adults in rural Bangladesh. We measured personal exposure to PM2.5 using gravimetric analysis of PM2.5 mass and BC by reflectance measurement between April 2016 and June 2019. The average 24-hour PM2.5 and BC concentration was 141.0μgm−3 and 13.8μgm−3 for females, and 91.7 μgm−3 and 10.1 μgm−3 for males, respectively....