Near infrared (NIR) spectroscopy with chemometrics was used for rapid source identification and component quantification of Arnebiae Radix. The modeling parameters were determined using the processing trajectory method. The quantitative model of target components was established using the model fusion method. The root mean square error of calibration (RMSEC), root mean square error of validation (RMSEP), determination coefficient of calibration (Rcal2) and validation (Rpre2), and the ratio of standard error of prediction to standard deviation...

Ankylosing spondylitis (AS) is a common inflammatory arthritis, with a high prevalence in patients in their mid-20s. Its pathogenesis is not well understood; however, genetic factors likely play a critical role. Epigenetic DNA changes may be involved in the pathogenesis of AS. In this study, we explored the methylation and transcription levels of the B7-H3 gene and its association with AS in an eastern Chinese Han population. Peripheral blood of AS patients and healthy controls...

Aminoglycosides exhibit ototoxicity by damaging mitochondria, which in turn generate reactive oxygen species that induce hair cell death and subsequent hearing loss. It is well known that damaged mitochondria are degraded by mitophagy, an important mitochondrial quality control system that maintains mitochondrial homeostasis and ensures cell survival. However, it is unclear whether dysregulation of mitophagy contributes to aminoglycoside-induced hair cell injury. In the current study, we found that PINK1-PRKN-mediated mitophagy was impaired in neomycin-treated hair...

Sponge iron (SI) is widely used in water treatment. As effluents from wastewater treatment plant (WWTP) require advanced treatment methodology, three forms of constructed wetlands (CWs): wetlands with sponge iron (SI), copper sulfate modified sponge iron (Cu/SI), and sponge iron coupled with solid carbon sources (C/SI), have been investigated in this paper for the removal effects of organic matter and nutrients in WWTP effluents, and the corresponding mechanisms have been analyzed. The results showed the...

The destruction of the ecological system caused by urban expansion has led to the environmental deterioration, cities have become increasingly vulnerable. In this study, six districts and counties along the Yellow River in Zhengzhou were selected as the study area. First, green infrastructure elements were extracted by morphological spatial pattern analysis. Then, outside the urban areas, we used connectivity analysis to evaluate the importance of core areas, adopted minimum cumulative resistance model to extract potential...

Cotton (Gossypium hirsutum) is an important economic crop, so it is of great significance to analyze its molecular mechanisms of resistance to Verticillium Wilt. The WRKY gene family encodes transcription factors (TFs) involved in plant resistance to biotic and abiotic stress. Here, we identified 17 group III WRKY genes in cotton based on the cotton genome project. The phylogenetic relationship and evolutionary of WRKY Group III TFs in Arabidopsis thaliana and G. hirsutum showed that...

The aim of this study was to develop a gambogic acid-loaded mixed micelles (GA-M) system, using Kolliphor HS15 and lecithin, for enhancement of oral bioavailability. GA-M was prepared using the thin film hydration method, and particle size and zeta potential indexes were used to determine the optimized formulation was optimized with taking particle size, zeta potential as indexes. The optimal GA-M system had a mean particle size in the nanometer range (87.22 ± 0.68 nm)...

To measure the effect of maternal family history of hypertension on preterm birth (PTB) and to identify factors that modified this association. A case-control study was nested in a prospective cohort of the entire pregnant population in Wuhan, China, from 2011 to 2013. Home-visit interviews were scheduled for all PTBs and their controls, to collect extensive information on maternal exposures to behavioral, environmental, and intergenerational risk factors of PTB. The effects of maternal family history...

Additional file 2: Table S2. Plasmids used in this study.

Additional file 3: Table S3. Oligonucleotides used in this study.

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method: supplemental document

Additional file 1: Table S1. PubMed search strategy. Table S2. Embase search strategy. Table S3. Cochrane library search strategy. Table S4. CNKI search strategy (in Chinese).

Additional file 3: Protein correlation heatmaps.

Additional file 4: Protein clusters.

Additional file 5: Inferred protein levels over time.

Additional file 1: List of immunity-related proteins measured.

Additional file 1: Table S1. The hepatic manifestations of the patient (Family-1-II-2) carrying TTC21B mutations at the age of 2 months

Additional file 1. Additional methods.

Additional file 1.

Macroautophagy/autophagy is a conserved degradation pathway in eukaryotes that is required for recycling unwanted intracellular components, maintaining homeostasis, and coping with biotic and abiotic stresses. Pathogens have evolved to subvert autophagic machinery by secreting host cell-entering effector proteins. Here, we provided evidence that an apple autophagy-related gene MdATG8i, activated autophagy and contributed to resistance against Valsa canker caused by Valsa mali (Vm) when being overexpressed in apple. MdATG8i interacted with a plastid elongation factor Tu...

Supplemental material, sj-pdf-2-imr-10.1177_03000605221134467 for Efficacy of median nerve electrical stimulation on the recovery of patients with consciousness disorders: a systematic review and meta-analysis by Peng Wang, Wei Cao, Hong Zhou, Huan Xin Zhang, Lunzhong Zhang, Li Liu, Yunlong Sui, Zhen Zhang, Xiaoyu Yin, Fan Yang and Li Kong in Journal of International Medical Research

Supplemental material, sj-pdf-3-imr-10.1177_03000605221134467 for Efficacy of median nerve electrical stimulation on the recovery of patients with consciousness disorders: a systematic review and meta-analysis by Peng Wang, Wei Cao, Hong Zhou, Huan Xin Zhang, Lunzhong Zhang, Li Liu, Yunlong Sui, Zhen Zhang, Xiaoyu Yin, Fan Yang and Li Kong in Journal of International Medical Research

Supplemental material, sj-pdf-5-imr-10.1177_03000605221134467 for Efficacy of median nerve electrical stimulation on the recovery of patients with consciousness disorders: a systematic review and meta-analysis by Peng Wang, Wei Cao, Hong Zhou, Huan Xin Zhang, Lunzhong Zhang, Li Liu, Yunlong Sui, Zhen Zhang, Xiaoyu Yin, Fan Yang and Li Kong in Journal of International Medical Research

Supplemental Material for The impact of comprehensive blood conservation program on major complications after total aortic arch replacement by Weidong Yan, Qiaoni Zhang, Sizhe Gao, Gang Liu, Yuan Teng, Jing Wang, Jian Wang, Boyi Zhou, Shujie Yan, and Bingyang Ji in Perfusion

Supplemental Material for The impact of comprehensive blood conservation program on major complications after total aortic arch replacement by Weidong Yan, Qiaoni Zhang, Sizhe Gao, Gang Liu, Yuan Teng, Jing Wang, Jian Wang, Boyi Zhou, Shujie Yan, and Bingyang Ji in Perfusion