279 Works

Neuronal mitochondria-targeted therapy for Alzheimer’s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems

Yang Han, Xiaoyang Chu, Lin Cui, Shiyao Fu, Chunsheng Gao, Yi Li & Baoshan Sun
Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer’s disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targeted therapy. However, the efficient intravenous delivery of therapeutic agents to neuronal mitochondria in the brain remains a major challenge due to the complicated physiological environment. Recently, biomaterials-based nanomedicine has been widely...

Out of pocket expenses in obsessive compulsive disorder

Margaret Heslin, Judith Gellatly, Rebecca Pedley, Jasmin Knopp-Hoffer, Gillian Hardy, Catherine Arundel, Penny Bee, Dean McMillan, Emily Peckham, Lina Gega, Michael Barkham, Peter Bower, Simon Gilbody, Karina Lovell & Sarah Byford
Despite anecdotal evidence that the out of pocket costs of OCD can be substantial in some cases, there is no evidence on how many people they affect, or the magnitude of these costs. This paper explores the type and quantity of out of pocket expenses reported by a large sample of adults with OCD. Data on out of pocket expenses were collected from participants taking part in the OCTET multi-centre randomised controlled trial. Participants were...

Super-dominant pathobiontic bacteria in the nasopharyngeal microbiota as causative agents of secondary bacterial infection in influenza patients

Tian Qin, Taoran Geng, Haijian Zhou, Yang Han, Hongyu Ren, Zhifeng Qiu, Xudong Nie, Tiekuan Du, Junrong Liang, Pengcheng Du, Wei Jiang, Taisheng Li & Jianguo Xu
The source of secondary lower respiratory tract bacterial infections in influenza patients is not fully understood. A case–control study was conducted during the 2017–2018 influenza epidemic period in Beijing, China. Nasopharyngeal swabs were collected from 52 virologically confirmed influenza patients and 24 healthy medical staff. The nasopharyngeal microbiota taxonomic composition was analysed using high-throughput sequencing of the 16S rRNA gene V3–V4 regions. The super-dominant pathobiontic bacterial genus (SDPG) was defined as that accounting for >50%...

Financing Community Energy Case Studies : Gwent Energy CIC

Iain Cairns, Matthew Hannon, Timothy Braunholtz-Speight, Carly McLachlan, Sarah Mander, Edward Manderson, Maria Sharmina & Jeff Hardy
This report presents the third of four case studies of UK community energy organisations conducted during 2018/19. These will later be included as part of a synthesis briefing alongside a series of sector-level interviews. The case study makes use of a combination of qualitative (e.g. interviews, organisation reports) and quantitative (e.g. financial reports) data. Summary of key lessons: The withdrawal of the FiT has made business model innovation necessary, whilst legacy revenues from the FiT...

Do Source Monitoring and Evidential Marking Support Children’s ToM Understanding?: A cross-linguistic study between Turkish and English speaking children

Birsu Kandemirci, Anna Theakston, Silke Brandt & Ditte Boeg

Training Study

Laura De Ruiter, Elena Lieven, Anna Theakston & Silke Brandt

Mixed-Methods Investigation of Shame in those who Self-Injure (MISSI)

Peter Taylor
Research study combining experience sampling and qualitative methods to investigate experiences of shame in those who self-injure

Cognitive Analytic Therapy-informed Containment for self-Harm (CATCH): A Feasibility Trial

Peter Taylor

Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Jing Yang, Yi Zhou, Yujuan Ban, Jing Mi, Ying He, Xinjuan Li, Zhengwei Liu, Keren Wang, Gaofeng Zhu, Wenmin Liu, Zhenghuai Tan & Zhipei Sang
In this study, a series of naringenin-O-alkylamine derivatives were designed and obtained by introducing an alkylamine fragment into the naringenin skeleton. The in vitro biological activity results revealed that compounds 5f and 7k showed good antioxidant activity with ORAC values of 2.3eq and 1.2eq, respectively. Compounds 5f and 7k were reversible and excellent huAChE inhibitors with IC50 values of 0.91 μM and 0.57 μM, respectively. Moreover, compounds 5f and 7k could inhibit self-induced Aβ1–42 aggregation...

The motivations of older adult peer-volunteers: a scoping review protocol

Helena Bilsborough, Chris Todd & Helen Hawley-Hague
A protocol for a scoping review summarising the motivations of older adults who are peer-volunteers within community-based settings, particularly within schemes that focus upon physical activity.

After The Music

Carlyn Murray, Hannah Guest, Chris Plack & Garreth Prendergast
Prolonged exposure to sounds at high levels causes temporary auditory shifts: reductions in outer-hair-cell function and elevations in audiometric thresholds that typically return to baseline in the hours or days following exposure. The degree of auditory shift is variable, seemingly depending not only on level and duration of exposure but other factors. One factor may be the degree of long-term "conditioning" noise exposure experienced by the individual, which may "toughen up" their ears and reduce...

Human teratogens and their impact on the developing brain: a scoping review

Matthew Bluett-Duncan & Rebecca Bromley
The impact of certain medication exposures in utero can be observed in the physical development of the fetus (e.g. patterns of congenital malformations or dysmorphic features) or in the form of growth disruption. Developmental trajectories within the fetal brain can also be susceptible to alteration and can manifest as lifelong neurodevelopmental impairments. Despite growing recognition of its importance as an outcome, a lack of coherence within the investigation of the neurodevelopmental outcomes remains. Important methodological...

Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease

Gaofeng Zhu, Ping Bai, Keren Wang, Jing Mi, Jing Yang, Jiaqi Hu, Yujuan Ban, Ran Xu, Rui Chen, Changning Wang, Lei Tang & Zhipei Sang
Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32, 0.56, 0.54, 0.73, and 0.86 μM, respectively) and moderate antioxidant activity. Moreover, compounds 5a, 5d, 5e, 5f, and 5h showed potent anti-inflammatory properties, remarkable effects on self-induced Aβ1-42 aggregation, and potent neuroprotective effect on...

Understanding suicidal thoughts and behaviours using common assessment measures: views of women and healthcare professionals

Kerry Hozhabrafkan
Two qualitative studies will be carried out, exploring communication about suicidal experiences in the perinatal period. The research aims specifically to investigate the use of brief, suicide questionnaire measures with women in this population. Participants will be asked to complete a selection of measures and will be interviewed about the process of doing so. In addition to understanding the appropriateness and acceptability of this method of assessing suicidality, the research also aims to understand how...

The Role of Secondary Memory in the Reading Span Task

Freya Amsbury & Antje Heinrich
Reading Span Tasks (RSTs) are used commonly within speech perception research as measures of working memory (WM). Following Baddeley and Hitch (1974), WM consists of storage components for the different modalities, also collectively known as short-term memory, and a processing component called central executive (CE). However, examining the RST as a psychologist, it seems likely it also relies on (and is therefore also a test of) long-term memory (LTM), or secondary memory (SM). Additionally, different...

Additional file 3 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 3. Full round 1 results.

Additional file 4 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 4. Summary round 1 results.

Additional file 5 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 5. Full round 2 results.

Additional file 7 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 7. Round 1 & 2 free-text comments.

Additional file 8 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 8. Round 1 free-text comments.

Additional file 1 of Does United Kingdom parliamentary attention follow social media posts?

John Bollenbacher, Niklas Loynes & John Bryden
Supplementary information (PDF 53 kB)

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

sj-pdf-1-bmi-10.1177_1177271917730306 – Supplemental material for Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation

Philip E Silkoff, Dave Singh, J Mark FitzGerald, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey C Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Mark T Dransfield, Frederic Baribaud, Vedrana S Susulic & Matthew J Loza
Supplemental material, sj-pdf-1-bmi-10.1177_1177271917730306 for Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation by Philip E Silkoff, Dave Singh, J Mark FitzGerald, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey C Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Mark T Dransfield, Frederic Baribaud, Vedrana S Susulic and Matthew J Loza in Biomarker Insights

Additional file 1 of Molecular analysis of knockdown resistance (kdr) mutations in the voltage-gated sodium channel gene of Aedes aegypti populations from Saudi Arabia

Abadi M. Mashlawi, Ashwaq M. Al-Nazawi, Elsiddig M. Noureldin, Hussain Alqahtani, Jazem A. Mahyoub, Jassada Saingamsook, Mustapha Debboun, Martha Kaddumukasa, Hesham M. Al-Mekhlafi & Catherine Walton
Additional file 1: Table S1. Localities/Districts, region, number of sites, coordinates and elevation (m = meter above the sea level) of collections of Aedes aegypti in Saudi Arabia. Table S2 Countries, regions, coordinates and collection year of Aedes aegypti in Southeast Asia. Table S3. Four synonymous mutations observed in domains IIS6 and IIIS6 of Aedes aegypti in Saudi Arabia and Southeast Asia. Table S4. A summary of vector control strategies and insecticide spraying regimes in...

Additional file 3 of Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis

Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li & Zekuan Xu
Additional file 3.

Registration Year

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Resource Types

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    279

Affiliations

  • University of Manchester
    279
  • Shanghai Jiao Tong University
    66
  • West China Hospital of Sichuan University
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  • Zhejiang University
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  • Sichuan University
    64
  • Huazhong Agricultural University
    62
  • Wuhan University
    62
  • University of South China
    60
  • Harbin Medical University
    60
  • Air Force Medical University
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