510 Works

Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke

Wei Zhang, Li Zhang, Wen jun Wang, Shanbo Ma, Mingming Wang, Minna Yao, Ruili Li, Wei wei Li, Xian Zhao, Dongmei Hu, Yi Ding & Jingwen Wang
Stroke is an illness with high morbidity, disability and mortality that presents a major clinical challenge. Sanhua decoction (SHD) has been widely used to treat ischaemic stroke in the clinic. However, the potential mechanism of SHD remains unknown. To elucidate the multitarget mechanism of SHD in ischaemic stroke through network pharmacology and bioinformatics analyses. Network pharmacology and experimental validation approach was used to investigate the bioactive ingredients, critical targets and potential mechanisms of SHD against...

Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke

Wei Zhang, Li Zhang, Wen jun Wang, Shanbo Ma, Mingming Wang, Minna Yao, Ruili Li, Wei wei Li, Xian Zhao, Dongmei Hu, Yi Ding & Jingwen Wang
Stroke is an illness with high morbidity, disability and mortality that presents a major clinical challenge. Sanhua decoction (SHD) has been widely used to treat ischaemic stroke in the clinic. However, the potential mechanism of SHD remains unknown. To elucidate the multitarget mechanism of SHD in ischaemic stroke through network pharmacology and bioinformatics analyses. Network pharmacology and experimental validation approach was used to investigate the bioactive ingredients, critical targets and potential mechanisms of SHD against...

Combined radiofrequency ablation or microwave ablation with transarterial chemoembolization can increase efficiency in intermediate-stage hepatocellular carcinoma without more complication: a systematic review and meta-analysis

Yao Yang, Hongli Yu, Lingyu Qi, Chenxi Liu, Yuemin Feng, Jianni Qi, Jie Li & Qiang Zhu
Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely used in combination with transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC) in clinical practice. We aim to compare the efficacy and safety of TACE combined with RFA or MWA versus TACE monotherapy for intermediate-stage HCC. We searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant studies. The outcomes included overall survival (OS), progression-free survival (PFS), local tumor control (LTC) rate, and major...

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong & Liduan Zheng
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a novel transcriptional activator of cytoprotective autophagy crucial for zinc homeostasis in cancer cells. Gain- and loss-of-function studies showed that E2F4 promoted autophagy in a cell cycle-dependent manner, resulting in facilitated degradation of MT (metallothionein) proteins, elevated distribution of Zn2+ within autophagosomes,...

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong & Liduan Zheng
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a novel transcriptional activator of cytoprotective autophagy crucial for zinc homeostasis in cancer cells. Gain- and loss-of-function studies showed that E2F4 promoted autophagy in a cell cycle-dependent manner, resulting in facilitated degradation of MT (metallothionein) proteins, elevated distribution of Zn2+ within autophagosomes,...

Reproducibility of the Infinium methylationEPIC BeadChip assay using low DNA amounts

Steffan Noe Christiansen, Jeppe Dyrberg Andersen, Marie-Louise Kampmann, Jing Liu, Mikkel Meyer Andersen, Jacob Tfelt-Hansen & Niels Morling
The Infinium MethylationEPIC BeadChip (EPIC) is a reliable method for measuring the DNA methylation of more than 850,000 CpG positions. In clinical and forensic settings, it is critical to be able to work with low DNA amounts without risking reduced reproducibility. We evaluated the EPIC for a range of DNA amounts using two-fold serial dilutions investigated on two different days. While the β-value distributions were generally unaffected by decreasing DNA amounts, the median squared Pearson’s...

Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer

Di Xu, Wen-Juan Tang, Yi-Zhi Zhu, Zhen Liu, Kai Yang, Ming-Xing Liang, Xiu Chen, Yang Wu, Jin-Hai Tang & Wei Zhang
To investigate the mechanism through which hyperthermia promotes exosome secretion and drug sensitivity in adriamycin-resistant breast cancer. We first evaluated the effect of hyperthermia on adriamycin-resistant breast cancer viability and used transmission electron microscopy, nanoparticle tracking analysis, and a bicinchoninic acid kit to validate the effect of hyperthermia on exosome secretion. The effective targeting molecules and pathways changed by hyperthermia were explored by RNA microarray and verified in vitro. The adriamycin-resistant MCF-7/ADR cells co-incubated with...

Phospholipase C is a novel regulator at the early stages of microspore embryogenesis in Nicotiana tabacum

Pan Luo, Aixi Jiang, Yi Zhou, Mingchun Yang, Xiaotong Zhou, Yong Yang, Jun Yu & Xingchun Tang
Microspore transfers the developmental fate into embryogenesis in vitro regulated by determinant factors of stress-induced. However, the key regulators of microspore embryogenesis (ME) are still largely undiscovered to reveal the mechanism of cell fate transition. Here, we report that Phospholipase C (PLC) is involved at the early stages of ME in Nicotiana tabacum. NtPLC2/3/4 are expressed at the initial stages of ME. The expression levels of NtPLC2/3 are transient activated after 3 days in culture,...

Determination of Glucose by the Catalysis of Luminol Chemiluminescence Using One-Step Synthesized Platinum/Silver Nanoparticles as a Peroxidase Mimetic

Miaomiao Tian, Liping Zhao, Ya Wang, Gang Liu & Peng Zhang
Bimetallic Pt/Ag nanoparticles (Pt/Ag NPs) were synthesized using 3-hydroxyphenyl-boronic acid as the reducing and stabilizing agent by a simple, one-step hydrothermal method. The bimetallic Pt/Ag NPs were demonstrated to possess intrinsic peroxidase mimetic catalytic activity for the luminol/H2O2 reaction to generate chemiluminescence (CL). The catalytic properties of the bimetallic Pt/Ag NPs were thoroughly investigated. The results showed that the combination of Pt and Ag greatly enhanced the chemiluminescence which is attributed to their synergy. Moreover,...

Determination of Glucose by the Catalysis of Luminol Chemiluminescence Using One-Step Synthesized Platinum/Silver Nanoparticles as a Peroxidase Mimetic

Miaomiao Tian, Liping Zhao, Ya Wang, Gang Liu & Peng Zhang
Bimetallic Pt/Ag nanoparticles (Pt/Ag NPs) were synthesized using 3-hydroxyphenyl-boronic acid as the reducing and stabilizing agent by a simple, one-step hydrothermal method. The bimetallic Pt/Ag NPs were demonstrated to possess intrinsic peroxidase mimetic catalytic activity for the luminol/H2O2 reaction to generate chemiluminescence (CL). The catalytic properties of the bimetallic Pt/Ag NPs were thoroughly investigated. The results showed that the combination of Pt and Ag greatly enhanced the chemiluminescence which is attributed to their synergy. Moreover,...

Identification and expression analysis of capsaicin biosynthesis pathway genes at genome level in Capsicum chinense

Wei Zhang, Dan Wu, Liping Zhang, Chengzhi Zhao, Huangying Shu, Shanhan Cheng, Zhiwei Wang, Jie Zhu & Pingwu Liu
Capsicum chinense is one of the best ingredients for making chili sauces and extracting capsaicin. In this study, we identified 59 genes associated with shikimic acid, phenylpropane, unsaturated fatty acids, phenylalanine, valine, leucine, isoleucine and other metabolic pathways based on pepper genome. In the present study, 58 of the 59 genes involved in capsaicin synthesis were found to be unevenly distributed on 11 chromosomes, and several genes with the same number of exons and high...

sj-doc-1-tct-10.1177_15330338221132669 - Supplemental material for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer

Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao & Xin Wang
Supplemental material, sj-doc-1-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment

sj-doc-1-tct-10.1177_15330338221132669 - Supplemental material for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer

Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao & Xin Wang
Supplemental material, sj-doc-1-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment

sj-doc-2-tct-10.1177_15330338221132669 - Supplemental material for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer

Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao & Xin Wang
Supplemental material, sj-doc-2-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment

Supplementary document for Polarization-multiplexed full-space metasurface simultaneously with ultrawide-angle antireflection and large-angle retroreflection - 6108639.pdf

zuntian chu, Tiefu Li, Jiafu Wang, yuxiang jia, JINMING JIANG, Ruichao Zhu, Lei Li & Shaobo Qu
Supplement 1

Additional file 1 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancer

Yuping Cai, Xinyi Shen, Lingeng Lu, Hong Yan, Huang Huang, Patricia Gaule, Engjel Muca, Casey M. Theriot, Zahra Rattray, Nicholas J. W. Rattray, Jun Lu, Nita Ahuja, Yawei Zhang, Philip B. Paty, Sajid A. Khan & Caroline H. Johnson
Additional file 1: Table S1. Names of the bile acids measured in tumor tissues. Table S2. Demographics of colon cancer patients from samples used within this study. Table S4. Comparison of bile acid abundance between RCCs and LCCs by sex and age. Table S5. Pearson correlation of glucuronic acid to bile acid abundances in patients with LCC ≥ 55 years old (n=99). Table S6. Correlations between prognosis-linked bile acid and T regulatory cell abundances in...

Additional file 3 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancer

Yuping Cai, Xinyi Shen, Lingeng Lu, Hong Yan, Huang Huang, Patricia Gaule, Engjel Muca, Casey M. Theriot, Zahra Rattray, Nicholas J. W. Rattray, Jun Lu, Nita Ahuja, Yawei Zhang, Philip B. Paty, Sajid A. Khan & Caroline H. Johnson
Additional file 3. R code for performing survival analysis.

Additional file 3 of Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler & Zhiping P. Pang
Additional file 3: Figure S3. NTS GLP-1 neuron projection mapping in the whole brain. Representative images of Gcg-cre BAC mouse injected with DIO-Chr2-EYFP.

sj-docx-1-tah-10.1177_20406207221134409 – Supplemental material for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia

Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng & Shaoyan Hu
Supplemental material, sj-docx-1-tah-10.1177_20406207221134409 for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia by Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng and Shaoyan Hu in Therapeutic Advances in Hematology

Supplemental Material - Functional Limitations and Physical Health in Community-Dwelling Medicare Advantage Beneficiaries: Variation by Race and Hispanic Subgroup

Jeff Luck, Diana Govier, Lan N. Ðoàn, Shyama Mahakalanda, Wei Zhang & Carolyn Mendez-Luck
Supplemental Material for Functional Limitations and Physical Health in Community-Dwelling Medicare Advantage Beneficiaries: Variation by Race and Hispanic Subgroup by Jeff Luck, Diana Govier, Lan N. Ðoàn, Shyama Mahakalanda, Wei Zhang, and Carolyn Mendez-Luck in Journal of Aging and Health

Additional file 1 of Relationship between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Lei Gao, Ping Zhang, Yan Wang, Wei Zhang, Jian Zhao, Ying Liu, Jing Liu & Shaoqiang He
Additional file 1.

Additional file 1 of Relationship between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Lei Gao, Ping Zhang, Yan Wang, Wei Zhang, Jian Zhao, Ying Liu, Jing Liu & Shaoqiang He
Additional file 1.

Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation

Junya Ning, Xiaoling Cui, Nan Li, Na Li, Baoxiang Zhao, Junying Miao & Zhaomin Lin
Hypochlorous acid (HOCl) is an essential signal molecule in cancer cells. Activated GRP78 ATPase by a HOCl probe named ZBM-H inhibits lung cancer cell growth. However, the role and underlying mechanism of GRP78 ATPase in lung cancer cell migration have not been established. Here, we reported that activation of GRP78 ATPase by ZBM-H suppressed A549 cell migration and inhibited EMT process. Notably, ZBM-H time-dependently decreased the protein level of integrin β4 (ITGB4) in A549 cells....

sj-pdf-4-wso-10.1177_17474930221125993 – Supplemental material for Effect of the Shanghai Stroke Service System (4S) on the quality of stroke care and outcomes: A prospective quality improvement project

Jiawen Xu, Yanan Xie, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, JianRen Liu, Jianhua Zhuang, Ying Xian, Haipeng Shen, Hao Li, David Z Wang, Bruce CV Campbell, Mark W Parsons, Yi Dong & Qiang Dong
Supplemental material, sj-pdf-4-wso-10.1177_17474930221125993 for Effect of the Shanghai Stroke Service System (4S) on the quality of stroke care and outcomes: A prospective quality improvement project by Jiawen Xu, Yanan Xie, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, JianRen Liu, Jianhua Zhuang, Ying Xian, Haipeng Shen, Hao Li, David Z Wang, Bruce CV Campbell, Mark W Parsons, Yi Dong and Qiang Dong in International Journal...

Additional file 3 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 3: Table S3. Comparison of clinical outcomes between early and delayed initiation of rituximab subgroups in rituximab cohort

Registration Year

  • 2022
    510

Resource Types

  • Text
    510

Affiliations

  • Shandong Provincial Hospital
    510
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    406
  • Fudan University
    402
  • Sichuan University
    362
  • Huazhong University of Science and Technology
    341
  • Shanghai Jiao Tong University
    341
  • Sun Yat-sen University
    318
  • Capital Medical University
    312
  • Chinese Academy of Sciences
    292
  • Shandong University
    288